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The intriguing role of soluble urokinase receptor in inflammatory diseases

Stéphanie Desmedt, Valérie Desmedt, Joris Delanghe UGent, Reinhart Speeckaert and Marijn Speeckaert UGent (2017) CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES. 54(2). p.117-133
abstract
Inflammation is a key player in the development of an increasing amount of diseases. The soluble urokinase plasminogen activator receptor (suPAR) is a highly flexible molecule with intrinsic chemotactic properties. This glycoprotein has been evaluated as a biomarker of inflammation, immune activation, organ damage and clinical outcome in several pathologies, including cardiovascular disease, hepatitis, renal disorders and rheumatic pathologies. The use of this early warning inflammatory biomarker could potentially improve the prediction of the severity of these diseases and mortality. In the present paper, we describe the general characteristics of suPAR and its intriguing role as a biomarker in different inflammatory diseases.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
PLASMINOGEN-ACTIVATOR RECEPTOR, FOCAL SEGMENTAL GLOMERULOSCLEROSIS, CRITICALLY-ILL PATIENTS, C-REACTIVE-PROTEIN, CORONARY-ARTERY-DISEASE, CHRONIC KIDNEY-DISEASE, INTENSIVE-CARE-UNIT, SERUM SUPAR LEVELS, CELL-ADHESION, CARDIOVASCULAR-DISEASE, Biomarker, chemotaxis, immune activation, inflammation, soluble, urokinase plasminogen activator receptor
journal title
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
Crit. Rev. Clin. Lab. Sci.
volume
54
issue
2
pages
117 - 133
Web of Science type
Review
Web of Science id
000395559000004
ISSN
1040-8363
1549-781X
DOI
10.1080/10408363.2016.1269310
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors contributed equally to this work
copyright statement
I have transferred the copyright for this publication to the publisher
id
8529593
handle
http://hdl.handle.net/1854/LU-8529593
date created
2017-08-25 08:09:32
date last changed
2017-09-06 11:41:46
@article{8529593,
  abstract     = {Inflammation is a key player in the development of an increasing amount of diseases. The soluble urokinase plasminogen activator receptor (suPAR) is a highly flexible molecule with intrinsic chemotactic properties. This glycoprotein has been evaluated as a biomarker of inflammation, immune activation, organ damage and clinical outcome in several pathologies, including cardiovascular disease, hepatitis, renal disorders and rheumatic pathologies. The use of this early warning inflammatory biomarker could potentially improve the prediction of the severity of these diseases and mortality. In the present paper, we describe the general characteristics of suPAR and its intriguing role as a biomarker in different inflammatory diseases.},
  author       = {Desmedt, St{\'e}phanie and Desmedt, Val{\'e}rie and Delanghe, Joris and Speeckaert, Reinhart and Speeckaert, Marijn},
  issn         = {1040-8363},
  journal      = {CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES},
  keyword      = {PLASMINOGEN-ACTIVATOR RECEPTOR,FOCAL SEGMENTAL GLOMERULOSCLEROSIS,CRITICALLY-ILL PATIENTS,C-REACTIVE-PROTEIN,CORONARY-ARTERY-DISEASE,CHRONIC KIDNEY-DISEASE,INTENSIVE-CARE-UNIT,SERUM SUPAR LEVELS,CELL-ADHESION,CARDIOVASCULAR-DISEASE,Biomarker,chemotaxis,immune activation,inflammation,soluble,urokinase plasminogen activator receptor},
  language     = {eng},
  number       = {2},
  pages        = {117--133},
  title        = {The intriguing role of soluble urokinase receptor in inflammatory diseases},
  url          = {http://dx.doi.org/10.1080/10408363.2016.1269310},
  volume       = {54},
  year         = {2017},
}

Chicago
Desmedt, Stéphanie, Valérie Desmedt, Joris Delanghe, Reinhart Speeckaert, and Marijn Speeckaert. 2017. “The Intriguing Role of Soluble Urokinase Receptor in Inflammatory Diseases.” Critical Reviews in Clinical Laboratory Sciences 54 (2): 117–133.
APA
Desmedt, S., Desmedt, V., Delanghe, J., Speeckaert, R., & Speeckaert, M. (2017). The intriguing role of soluble urokinase receptor in inflammatory diseases. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 54(2), 117–133.
Vancouver
1.
Desmedt S, Desmedt V, Delanghe J, Speeckaert R, Speeckaert M. The intriguing role of soluble urokinase receptor in inflammatory diseases. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES. 2017;54(2):117–33.
MLA
Desmedt, Stéphanie, Valérie Desmedt, Joris Delanghe, et al. “The Intriguing Role of Soluble Urokinase Receptor in Inflammatory Diseases.” CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES 54.2 (2017): 117–133. Print.