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The leptin receptor complex : heavier than expected?

Joris Wauman (UGent) , Lennart Zabeau (UGent) and Jan Tavernier (UGent)
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Abstract
Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the body weight by balancing food intake and energy expenditure. However, this adipocyte-derived hormone also directs peripheral processes, including immunity, reproduction, and bone metabolism. Leptin, therefore, can act as a metabolic switch connecting the body's nutritional status to high energy consuming processes. We provide an extensive overview of current structural insights on the leptin-ObR interface and ObR activation, coupling to signaling pathways and their negative regulation, and leptin functioning under normal and pathophysiological conditions (obesity, autoimmunity, cancer,.). We also discuss possible cross-talk with other receptor systems on the receptor (extracellular) and signaling cascade (intracellular) levels.
Keywords
leptin, leptin receptor, activation, signaling, cross-talk, leptin resistance, GROWTH-FACTOR RECEPTOR, DIET-INDUCED OBESITY, HYPOTHALAMIC PROOPIOMELANOCORTIN NEURONS, ACTIVATED PROTEIN-KINASE, BREAST-CANCER CELLS, ESOPHAGEAL ADENOCARCINOMA CELLS, ENDOPLASMIC-RETICULUM STRESS, CYTOSOLIC PHOSPHOLIPASE A(2), INDUCED INSULIN-RESISTANCE, CONTROLS ENERGY-BALANCE

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Citation

Please use this url to cite or link to this publication:

Chicago
Wauman, Joris, Lennart Zabeau, and Jan Tavernier. 2017. “The Leptin Receptor Complex : Heavier Than Expected?” Frontiers in Endocrinology 8: 1–20.
APA
Wauman, J., Zabeau, L., & Tavernier, J. (2017). The leptin receptor complex : heavier than expected? FRONTIERS IN ENDOCRINOLOGY, 8, 1–20.
Vancouver
1.
Wauman J, Zabeau L, Tavernier J. The leptin receptor complex : heavier than expected? FRONTIERS IN ENDOCRINOLOGY. 2017;8:1–20.
MLA
Wauman, Joris, Lennart Zabeau, and Jan Tavernier. “The Leptin Receptor Complex : Heavier Than Expected?” FRONTIERS IN ENDOCRINOLOGY 8 (2017): 1–20. Print.
@article{8529574,
  abstract     = {Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the body weight by balancing food intake and energy expenditure. However, this adipocyte-derived hormone also directs peripheral processes, including immunity, reproduction, and bone metabolism. Leptin, therefore, can act as a metabolic switch connecting the body's nutritional status to high energy consuming processes. We provide an extensive overview of current structural insights on the leptin-ObR interface and ObR activation, coupling to signaling pathways and their negative regulation, and leptin functioning under normal and pathophysiological conditions (obesity, autoimmunity, cancer,.). We also discuss possible cross-talk with other receptor systems on the receptor (extracellular) and signaling cascade (intracellular) levels.},
  author       = {Wauman, Joris and Zabeau, Lennart and Tavernier, Jan},
  issn         = {1664-2392},
  journal      = {FRONTIERS IN ENDOCRINOLOGY},
  language     = {eng},
  pages        = {1--20},
  title        = {The leptin receptor complex : heavier than expected?},
  url          = {http://dx.doi.org/10.3389/fendo.2017.00030},
  volume       = {8},
  year         = {2017},
}

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