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Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology

(2004) IMMUNITY. 20(5). p.623-635
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Abstract
Macrophage/neutrophil-specific IL-4 receptor a-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre) IL4-Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by T(H)2 development and goblet cell hyperplasia. In contrast, LysM(Cre)IL-4Ralpha(-/flox) mice were extremely susceptible to Schistosoma mansoni infection with 100% mortality during acute infection. Mortality was not dependent on neutrophils and occurred in the presence of T(H)2/Type 2 responses, granuloma formation, and egg-induced fibrosis. Death was associated with increased T(H)1 cytokines, hepatic and intestinal histopathology, increased NOS-2 activity, impaired egg expulsion, and sepsis. IL-10 was not able to compensate for the absence of IL-4/IL-13-activated alternative macrophages. Together, this shows that alternative macrophages are essential during schistosomiasis for protection against organ injury through downregulation of egg-induced inflammation.
Keywords
SYNTHASE ARGINASE BALANCE, TYPE-2 CYTOKINE RESPONSES, MOUSE BONE-MARROW, NITRIC-OXIDE, GRANULOMATOUS PATHOLOGY, RECEPTOR EXPRESSION, LEISHMANIA-MAJOR, IN-VIVO, T-CELLS, MICE

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Chicago
Herbert, De’Broski R, Christoph Hölscher, Markus Mohrs, Berenice Arendse, Anita Schwegmann, Magdalena Radwanska, Mosiuoa Leeto, et al. 2004. “Alternative Macrophage Activation Is Essential for Survival During Schistosomiasis and Downmodulates T Helper 1 Responses and Immunopathology.” Immunity 20 (5): 623–635.
APA
Herbert, D. R., Hölscher, C., Mohrs, M., Arendse, B., Schwegmann, A., Radwanska, M., Leeto, M., et al. (2004). Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. IMMUNITY, 20(5), 623–635.
Vancouver
1.
Herbert DR, Hölscher C, Mohrs M, Arendse B, Schwegmann A, Radwanska M, et al. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. IMMUNITY. 2004;20(5):623–35.
MLA
Herbert, De’Broski R et al. “Alternative Macrophage Activation Is Essential for Survival During Schistosomiasis and Downmodulates T Helper 1 Responses and Immunopathology.” IMMUNITY 20.5 (2004): 623–635. Print.
@article{8528993,
  abstract     = {Macrophage/neutrophil-specific IL-4 receptor a-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre) IL4-Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by T(H)2 development and goblet cell hyperplasia. In contrast, LysM(Cre)IL-4Ralpha(-/flox) mice were extremely susceptible to Schistosoma mansoni infection with 100\% mortality during acute infection. Mortality was not dependent on neutrophils and occurred in the presence of T(H)2/Type 2 responses, granuloma formation, and egg-induced fibrosis. Death was associated with increased T(H)1 cytokines, hepatic and intestinal histopathology, increased NOS-2 activity, impaired egg expulsion, and sepsis. IL-10 was not able to compensate for the absence of IL-4/IL-13-activated alternative macrophages. Together, this shows that alternative macrophages are essential during schistosomiasis for protection against organ injury through downregulation of egg-induced inflammation.},
  author       = {Herbert, De'Broski R and H{\"o}lscher, Christoph and Mohrs, Markus and Arendse, Berenice and Schwegmann, Anita and Radwanska, Magdalena and Leeto, Mosiuoa and Kirsch, Richard and Hall, Pauline and Mossmann, Horst and Claussen, Bj{\"o}rn and F{\"o}rster, Irmgard and Brombacher, Frank},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  language     = {eng},
  number       = {5},
  pages        = {623--635},
  title        = {Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology},
  url          = {http://dx.doi.org/10.1016/s1074-7613(04)00107-4},
  volume       = {20},
  year         = {2004},
}

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