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Interferon‐γ and nitric oxide in combination with antibodies are key protective host immune factors during Trypanosoma congolense Tc13 Infections

(2006) JOURNAL OF INFECTIOUS DISEASES. 193(11). p.1575-1583
Author
Organization
Abstract
The control of chronic Trypanosoma congolense trypanosomiasis was analyzed using several gene-deficient mouse strains. First, interferon (IFN)-gamma receptor ( IFN-gamma-R)-deficient mice were used to show that IFN-gamma-mediated immune activation is crucial for parasitemia control. Second, infections in major histocompatibility complex (MHC) class II-deficient mice indicate that this molecule is needed for initiation of IFN-gamma and subsequent tumor necrosis factor (TNF) production. Downstream of IFN-gamma-R signaling, inducible NO synthase (iNOS)-dependent trypanosome killing occurs, as is shown by the hypersusceptible phenotype of iNOS-deficient mice. Besides proinflammatory responses, B cells and, more specifically, immunoglobulin (Ig) G antibodies are crucial for parasite killing. Hence, parasitemia control is abolished in B cell-deficient mice, whereas IgM-deficient mice control the infection as efficiently as do wild-type mice. In addition, splenectomized mice that have a normal IgM response but an impaired IgG2a/3 response fail to control T. congolense infection. Collectively, these results suggest that host protective immunity against T. congolense is critically dependent on the combined action of the proinflammatory mediators/effectors IFN-gamma, TNF, and NO and antiparasite IgGs.
Keywords
EXPERIMENTAL AFRICAN TRYPANOSOMIASIS, NECROSIS-FACTOR-ALPHA, IFN-GAMMA, TNF-ALPHA, ANTIGENIC VARIATION, INNATE RESISTANCE, SUSCEPTIBLE MICE, DEFICIENT MICE, RESPONSES, CATTLE

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Chicago
Magez, Stefan, Magdalena Radwanska, Michael Drennan, Lizette Fick, Toya Nath Baral, Frank Brombacher, and Patrick De Baetselier. 2006. “Interferon‐γ and Nitric Oxide in Combination with Antibodies Are Key Protective Host Immune Factors During Trypanosoma Congolense Tc13 Infections.” Journal of Infectious Diseases 193 (11): 1575–1583.
APA
Magez, S., Radwanska, M., Drennan, M., Fick, L., Baral, T. N., Brombacher, F., & De Baetselier, P. (2006). Interferon‐γ and nitric oxide in combination with antibodies are key protective host immune factors during Trypanosoma congolense Tc13 Infections. JOURNAL OF INFECTIOUS DISEASES, 193(11), 1575–1583.
Vancouver
1.
Magez S, Radwanska M, Drennan M, Fick L, Baral TN, Brombacher F, et al. Interferon‐γ and nitric oxide in combination with antibodies are key protective host immune factors during Trypanosoma congolense Tc13 Infections. JOURNAL OF INFECTIOUS DISEASES. 2006;193(11):1575–83.
MLA
Magez, Stefan et al. “Interferon‐γ and Nitric Oxide in Combination with Antibodies Are Key Protective Host Immune Factors During Trypanosoma Congolense Tc13 Infections.” JOURNAL OF INFECTIOUS DISEASES 193.11 (2006): 1575–1583. Print.
@article{8528991,
  abstract     = {The control of chronic Trypanosoma congolense trypanosomiasis was analyzed using several gene-deficient mouse strains. First, interferon (IFN)-gamma receptor ( IFN-gamma-R)-deficient mice were used to show that IFN-gamma-mediated immune activation is crucial for parasitemia control. Second, infections in major histocompatibility complex (MHC) class II-deficient mice indicate that this molecule is needed for initiation of IFN-gamma and subsequent tumor necrosis factor (TNF) production. Downstream of IFN-gamma-R signaling, inducible NO synthase (iNOS)-dependent trypanosome killing occurs, as is shown by the hypersusceptible phenotype of iNOS-deficient mice. Besides proinflammatory responses, B cells and, more specifically, immunoglobulin (Ig) G antibodies are crucial for parasite killing. Hence, parasitemia control is abolished in B cell-deficient mice, whereas IgM-deficient mice control the infection as efficiently as do wild-type mice. In addition, splenectomized mice that have a normal IgM response but an impaired IgG2a/3 response fail to control T. congolense infection. Collectively, these results suggest that host protective immunity against T. congolense is critically dependent on the combined action of the proinflammatory mediators/effectors IFN-gamma, TNF, and NO and antiparasite IgGs.},
  author       = {Magez, Stefan and Radwanska, Magdalena and Drennan, Michael and Fick, Lizette and Baral, Toya~Nath and Brombacher, Frank and De Baetselier, Patrick},
  issn         = {0022-1899},
  journal      = {JOURNAL OF INFECTIOUS DISEASES},
  language     = {eng},
  number       = {11},
  pages        = {1575--1583},
  title        = {Interferon\unmatched{2010}\ensuremath{\gamma} and nitric oxide in combination with antibodies are key protective host immune factors during Trypanosoma congolense Tc13 Infections},
  url          = {http://dx.doi.org/10.1086/503808},
  volume       = {193},
  year         = {2006},
}

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