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Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage‐derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing

(2007) JOURNAL OF INFECTIOUS DISEASES. 196(6). p.954-962
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Organization
Abstract
Control of Tiypanosoma congolense infections requires an early cell-mediated immune response. To unravel the role of tumor necrosis factor (TNF) in this process, 6 different T congolense strains were used in 6 different gene-deficient mouse models that included TNF-/-, TNF receptor-1 (TNFp55)(-/-), and TNF receptor-2 (TNFp75)(-/-) mice, 2 cell type-specific TNF-/- mice, as well as TNF-knock-in mice that expressed only membrane-bound TNE Our results indicate that soluble TNF produced by macrophages/neutrophils and TNFp55 signaling are essential and sufficient to control parasitemia. The downstream mechanism in the control of T congolense infection depends on inducible nitric oxide synthase activation in the liver. Such a role for nitric oxide is corroborated ex vivo, because the inhibitor N-G-monomethyl-L-arginine blocks the trypanolytic activity of the adherent liver cell population, whereas exogenous interferon-gamma that stimulates nitric oxide production enhances parasite killing. In conclusion, the control of T congolense infection depends on macrophage/neutrophil-derived soluble TNF and intact TNFp55 signaling, which induces trypanolytic nitric oxide.
Keywords
EXPERIMENTAL AFRICAN TRYPANOSOMIASIS, ALPHA-DEFICIENT MICE, INNATE RESISTANCE, SUSCEPTIBLE MICE, INTERFERON-GAMMA, BONE-MARROW, IN-VIVO, INFECTION, CELLS, CACHECTIN

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Chicago
Magez, Stefan, Magdalena Radwanska, Michael Drennan, Lizette Fick, Toya Nath Baral, Nasiema Allie, Muazzam Jacobs, et al. 2007. “Tumor Necrosis Factor (TNF) Receptor-1 (TNFp55) Signal Transduction and Macrophage‐derived Soluble TNF Are Crucial for Nitric Oxide-mediated Trypanosoma Congolense Parasite Killing.” Journal of Infectious Diseases 196 (6): 954–962.
APA
Magez, S., Radwanska, M., Drennan, M., Fick, L., Baral, T. N., Allie, N., Jacobs, M., et al. (2007). Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage‐derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing. JOURNAL OF INFECTIOUS DISEASES, 196(6), 954–962.
Vancouver
1.
Magez S, Radwanska M, Drennan M, Fick L, Baral TN, Allie N, et al. Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage‐derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing. JOURNAL OF INFECTIOUS DISEASES. 2007;196(6):954–62.
MLA
Magez, Stefan et al. “Tumor Necrosis Factor (TNF) Receptor-1 (TNFp55) Signal Transduction and Macrophage‐derived Soluble TNF Are Crucial for Nitric Oxide-mediated Trypanosoma Congolense Parasite Killing.” JOURNAL OF INFECTIOUS DISEASES 196.6 (2007): 954–962. Print.
@article{8528988,
  abstract     = {Control of Tiypanosoma congolense infections requires an early cell-mediated immune response. To unravel the role of tumor necrosis factor (TNF) in this process, 6 different T congolense strains were used in 6 different gene-deficient mouse models that included TNF-/-, TNF receptor-1 (TNFp55)(-/-), and TNF receptor-2 (TNFp75)(-/-) mice, 2 cell type-specific TNF-/- mice, as well as TNF-knock-in mice that expressed only membrane-bound TNE Our results indicate that soluble TNF produced by macrophages/neutrophils and TNFp55 signaling are essential and sufficient to control parasitemia. The downstream mechanism in the control of T congolense infection depends on inducible nitric oxide synthase activation in the liver. Such a role for nitric oxide is corroborated ex vivo, because the inhibitor N-G-monomethyl-L-arginine blocks the trypanolytic activity of the adherent liver cell population, whereas exogenous interferon-gamma that stimulates nitric oxide production enhances parasite killing. In conclusion, the control of T congolense infection depends on macrophage/neutrophil-derived soluble TNF and intact TNFp55 signaling, which induces trypanolytic nitric oxide.},
  author       = {Magez, Stefan and Radwanska, Magdalena and Drennan, Michael and Fick, Lizette and Baral, Toya~Nath and Allie, Nasiema and Jacobs, Muazzam and Nedospasov, Sergei and Brombacher, Frank and Ryffel, Bernard and De Baetselier, Patrick},
  issn         = {0022-1899},
  journal      = {JOURNAL OF INFECTIOUS DISEASES},
  language     = {eng},
  number       = {6},
  pages        = {954--962},
  title        = {Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage\unmatched{2010}derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing},
  url          = {http://dx.doi.org/10.1086/520815},
  volume       = {196},
  year         = {2007},
}

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