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Current status of vaccination against African trypanosomiasis

(2010) PARASITOLOGY. 137(14). p.2017-2027
Author
Organization
Abstract
Anti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigentic variation of the parasite surface coat has been considered the major obstacle in the development of a functional vaccine, recent research into the biology of B cells has indicated that the problems might go further than that. This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology.
Keywords
Trypanosomiasis, vaccination, B cells, INVARIANT SURFACE GLYCOPROTEINS, BLOOD-STREAM FORMS, GLOSSINA-MORSITANS-MORSITANS, VARIABLE ANTIGEN TYPES, NECROSIS-FACTOR-ALPHA, B.-BRUCEI INFECTION, TSETSE-FLY, ANTIBODY-RESPONSES, BOVINE TRYPANOSOMIASIS, PLASMODIUM-FALCIPARUM

Citation

Please use this url to cite or link to this publication:

Chicago
Magez, Stefan, Guy Calhon, Thao Tran, Benoit Stijlemans, and Magdalena Radwanska. 2010. “Current Status of Vaccination Against African Trypanosomiasis.” Parasitology 137 (14): 2017–2027.
APA
Magez, S., Calhon, G., Tran, T., Stijlemans, B., & Radwanska, M. (2010). Current status of vaccination against African trypanosomiasis. PARASITOLOGY, 137(14), 2017–2027.
Vancouver
1.
Magez S, Calhon G, Tran T, Stijlemans B, Radwanska M. Current status of vaccination against African trypanosomiasis. PARASITOLOGY. 2010;137(14):2017–27.
MLA
Magez, Stefan et al. “Current Status of Vaccination Against African Trypanosomiasis.” PARASITOLOGY 137.14 (2010): 2017–2027. Print.
@article{8528985,
  abstract     = {Anti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigentic variation of the parasite surface coat has been considered the major obstacle in the development of a functional vaccine, recent research into the biology of B cells has indicated that the problems might go further than that. This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology.},
  author       = {Magez, Stefan and Calhon, Guy and Tran, Thao and Stijlemans, Benoit and Radwanska, Magdalena},
  issn         = {0031-1820},
  journal      = {PARASITOLOGY},
  number       = {14},
  pages        = {2017--2027},
  title        = {Current status of vaccination against African trypanosomiasis},
  url          = {http://dx.doi.org/10.1017/s0031182010000223},
  volume       = {137},
  year         = {2010},
}

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