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Long non-coding RNAs in leukemia : biology and clinical impact

Tim Lammens (UGent) , Kaat Durinck (UGent) , Annelynn Wallaert (UGent) , Franki Speleman (UGent) and Pieter Van Vlierberghe (UGent)
(2017) CURRENT OPINION IN HEMATOLOGY. 24(4). p.353-358
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Abstract
Purpose of review: Over the last years, long non-coding RNAs (lncRNAs) have emerged as putative regulators of malignant hematopoietic development. Here, we review recent literature on the involvement of lncRNAs in leukemia, including their role in driving or sustaining disease and their potential impact on diagnosis, classification, and prognosis. Recent findings: Leukemogenesis is a complex process resulting from the accumulation of multiple genetic alterations. Over the last years, advances in high-throughput sequencing and transcriptome profiling have enabled the identification of lncRNAs involved in leukemia development. lncRNAs are able to distinguish different subtypes of human leukemia and several reports have identified specific patterns of lncRNA expression associated with clinical patient characteristics. Although functional studies on the actual role of these lncRNAs during transformation remain scarce, emerging evidence suggests that complex interactions between coding and non-coding transcript are truly involved in leukemia development. Summary: Introduction of lncRNAs as an additional layer of complexity in human leukemia might provide new molecular genetic insights in the biology of this disease and could create unique opportunities for the identification of novel drug targets and diagnostic or prognostic biomarkers.
Keywords
biomarker, leukemia, long non-coding RNAs, resistance and prognosis, ACUTE LYMPHOBLASTIC-LEUKEMIA, ACUTE MYELOID-LEUKEMIA, CHRONIC LYMPHOCYTIC-LEUKEMIA, CELL-PROLIFERATION, LNCRNA, DIFFERENTIATION, OVEREXPRESSION, TRANSCRIPTION, EXPRESSION, RESISTANCE

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Chicago
Lammens, Tim, Kaat Durinck, Annelynn Wallaert, Franki Speleman, and Pieter Van Vlierberghe. 2017. “Long Non-coding RNAs in Leukemia : Biology and Clinical Impact.” Current Opinion in Hematology 24 (4): 353–358.
APA
Lammens, T., Durinck, K., Wallaert, A., Speleman, F., & Van Vlierberghe, P. (2017). Long non-coding RNAs in leukemia : biology and clinical impact. CURRENT OPINION IN HEMATOLOGY, 24(4), 353–358.
Vancouver
1.
Lammens T, Durinck K, Wallaert A, Speleman F, Van Vlierberghe P. Long non-coding RNAs in leukemia : biology and clinical impact. CURRENT OPINION IN HEMATOLOGY. 2017;24(4):353–8.
MLA
Lammens, Tim, Kaat Durinck, Annelynn Wallaert, et al. “Long Non-coding RNAs in Leukemia : Biology and Clinical Impact.” CURRENT OPINION IN HEMATOLOGY 24.4 (2017): 353–358. Print.
@article{8528869,
  abstract     = {Purpose of review: Over the last years, long non-coding RNAs (lncRNAs) have emerged as putative regulators of malignant hematopoietic development. Here, we review recent literature on the involvement of lncRNAs in leukemia, including their role in driving or sustaining disease and their potential impact on diagnosis, classification, and prognosis.
Recent findings: Leukemogenesis is a complex process resulting from the accumulation of multiple genetic alterations. Over the last years, advances in high-throughput sequencing and transcriptome profiling have enabled the identification of lncRNAs involved in leukemia development. lncRNAs are able to distinguish different subtypes of human leukemia and several reports have identified specific patterns of lncRNA expression associated with clinical patient characteristics. Although functional studies on the actual role of these lncRNAs during transformation remain scarce, emerging evidence suggests that complex interactions between coding and non-coding transcript are truly involved in leukemia development.
Summary: Introduction of lncRNAs as an additional layer of complexity in human leukemia might provide new molecular genetic insights in the biology of this disease and could create unique opportunities for the identification of novel drug targets and diagnostic or prognostic biomarkers.},
  author       = {Lammens, Tim and Durinck, Kaat and Wallaert, Annelynn and Speleman, Franki and Van Vlierberghe, Pieter},
  issn         = {1065-6251},
  journal      = {CURRENT OPINION IN HEMATOLOGY},
  keywords     = {biomarker,leukemia,long non-coding RNAs,resistance and prognosis,ACUTE LYMPHOBLASTIC-LEUKEMIA,ACUTE MYELOID-LEUKEMIA,CHRONIC LYMPHOCYTIC-LEUKEMIA,CELL-PROLIFERATION,LNCRNA,DIFFERENTIATION,OVEREXPRESSION,TRANSCRIPTION,EXPRESSION,RESISTANCE},
  language     = {eng},
  number       = {4},
  pages        = {353--358},
  title        = {Long non-coding RNAs in leukemia : biology and clinical impact},
  url          = {http://dx.doi.org/10.1097/MOH.0000000000000354},
  volume       = {24},
  year         = {2017},
}

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