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Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation

Robrecht Dockx (UGent) , Kathelijne Peremans (UGent) , Romain Duprat (UGent) , Lise Vlerick, Nick Van Laeken (UGent) , Jimmy Saunders (UGent) , Ingeborgh Polis (UGent) , Filip De Vos (UGent) and Chris Baeken (UGent)
(2017) PEERJ. 5.
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Abstract
Background. In humans, non-stereotactic frameless neuronavigation systems are used as a topographical tool for non-invasive brain stimulation methods such as Transcranial Magnetic Stimulation (TMS). TMS studies in clogs may provide treatment modalities for several neuropsychological disorders in dogs. Nevertheless, an accurate non-invasive localization of a stimulation target has not yet been performed in this species. Hypothesis. This study was primarily put forward to externally locate the left frontal cortex in 18 healthy dogs by means of a human non-stereotactic neuronavigation system. Secondly, the accuracy of the external localization was assessed. Animals. A total of 18 healthy dogs, drawn at random from the research colony present at the faculty of Veterinary Medicine (Ghent University), were used. Methods. Two sets of coordinates (X, Y, Z and X", Y", Z") were compared on each dog their tornographical dataset. Results. The non-stereotactic neuronavigation system was able to externally locate the frontal cortex in dogs with accuracy comparable with human studies. Conclusion and clinical importance. This result indicates that a non-stereotactic neuronavigation system can accurately externally locate the left frontal cortex and paves the way to use guided non-invasive brain stimulation methods as an alternative treatment procedure for neurological and behavioral disorders in dogs. This technique could, in analogy with human guided non-invasive brain stimulation, provide a better treatment outcome for dogs suffering from anxiety disorders when compared to its non-guided alternative.
Keywords
Canine, Non-stereotactic, Brain, Neuronavigation, TMS, Neuropsychiatric disorders, TRANSCRANIAL MAGNETIC STIMULATION, BRAIN BIOPSY, STEREOTACTIC SYSTEM, PLACEMENT, RECEPTOR, NEUROSURGERY, NAVIGATION, DEVICE, MODEL

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Citation

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MLA
Dockx, Robrecht et al. “Accurate External Localization of the Left Frontal Cortex in Dogs by Using Pointer Based Frameless Neuronavigation.” PEERJ 5 (2017): n. pag. Print.
APA
Dockx, R., Peremans, K., Duprat, R., Vlerick, L., Van Laeken, N., Saunders, J., Polis, I., et al. (2017). Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation. PEERJ, 5.
Chicago author-date
Dockx, Robrecht, Kathelijne Peremans, Romain Duprat, Lise Vlerick, Nick Van Laeken, Jimmy Saunders, Ingeborgh Polis, Filip De Vos, and Chris Baeken. 2017. “Accurate External Localization of the Left Frontal Cortex in Dogs by Using Pointer Based Frameless Neuronavigation.” Peerj 5.
Chicago author-date (all authors)
Dockx, Robrecht, Kathelijne Peremans, Romain Duprat, Lise Vlerick, Nick Van Laeken, Jimmy Saunders, Ingeborgh Polis, Filip De Vos, and Chris Baeken. 2017. “Accurate External Localization of the Left Frontal Cortex in Dogs by Using Pointer Based Frameless Neuronavigation.” Peerj 5.
Vancouver
1.
Dockx R, Peremans K, Duprat R, Vlerick L, Van Laeken N, Saunders J, et al. Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation. PEERJ. 2017;5.
IEEE
[1]
R. Dockx et al., “Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation,” PEERJ, vol. 5, 2017.
@article{8528707,
  abstract     = {{Background. In humans, non-stereotactic frameless neuronavigation systems are used as a topographical tool for non-invasive brain stimulation methods such as Transcranial Magnetic Stimulation (TMS). TMS studies in clogs may provide treatment modalities for several neuropsychological disorders in dogs. Nevertheless, an accurate non-invasive localization of a stimulation target has not yet been performed in this species. 
Hypothesis. This study was primarily put forward to externally locate the left frontal cortex in 18 healthy dogs by means of a human non-stereotactic neuronavigation system. Secondly, the accuracy of the external localization was assessed. 
Animals. A total of 18 healthy dogs, drawn at random from the research colony present at the faculty of Veterinary Medicine (Ghent University), were used. 
Methods. Two sets of coordinates (X, Y, Z and X", Y", Z") were compared on each dog their tornographical dataset. 
Results. The non-stereotactic neuronavigation system was able to externally locate the frontal cortex in dogs with accuracy comparable with human studies. 
Conclusion and clinical importance. This result indicates that a non-stereotactic neuronavigation system can accurately externally locate the left frontal cortex and paves the way to use guided non-invasive brain stimulation methods as an alternative treatment procedure for neurological and behavioral disorders in dogs. This technique could, in analogy with human guided non-invasive brain stimulation, provide a better treatment outcome for dogs suffering from anxiety disorders when compared to its non-guided alternative.}},
  articleno    = {{e3425}},
  author       = {{Dockx, Robrecht and Peremans, Kathelijne and Duprat, Romain and Vlerick, Lise and Van Laeken, Nick and Saunders, Jimmy and Polis, Ingeborgh and De Vos, Filip and Baeken, Chris}},
  issn         = {{2167-8359}},
  journal      = {{PEERJ}},
  keywords     = {{Canine,Non-stereotactic,Brain,Neuronavigation,TMS,Neuropsychiatric disorders,TRANSCRANIAL MAGNETIC STIMULATION,BRAIN BIOPSY,STEREOTACTIC SYSTEM,PLACEMENT,RECEPTOR,NEUROSURGERY,NAVIGATION,DEVICE,MODEL}},
  language     = {{eng}},
  pages        = {{12}},
  title        = {{Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation}},
  url          = {{http://dx.doi.org/10.7717/peerj.3425}},
  volume       = {{5}},
  year         = {{2017}},
}

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