Advanced search
2 files | 1.33 MB Add to list

In vitro biological activities of gold(I) and gold(III) bis(N-heterocyclic carbene) complexes

(2017) CHEMISTRYSELECT. 2(19). p.5316-5320
Author
Organization
Abstract
The aim of this research is to evaluate for the first time the in vitro leishmanicidal activity and inhibition of alpha-glucosidase and beta-glucuronidase of new gold(I) and gold(III) complexes involving N-heterocyclic carbene (NHC) ligands, with the general formula [Au(X)(n)(NHC) R-2][BF4] (X= Cl, OAc, R= various aromatic and aliphatic substituents). The Au(III) complexes were shown to have a significant antileishmanial activity, and were also found to be more potent inhibitors of alpha-glucosidase and beta-glucuronidase enzymes than the standard drugs. Some complexes were also identified as potent anti-inflammatory agents with activity comparable to that of tested standard drugs, allopurinol and ibuprofen. These gold complexes were also evaluated for their in vitro cytotoxic activity against HeLa (cervical cancer), MCF-3 (breast cancer), and 3T3 (mouse fibroblast) cell lines.
Keywords
Anti-inflammatory, Cytotoxicity, Enzyme inhibition, Gold complexes, N-heterocyclic carbene, ALPHA-GLUCOSIDASE INHIBITORS, ANTICANCER AGENTS, BETA-GLUCURONIDASE, THIOREDOXIN REDUCTASE, ANTITUMOR AGENTS, CANCER-CELLS, MALTASE-GLUCOAMYLASE, CYTOTOXICITY, LEISHMANIA, EXPRESSION

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 663.08 KB
  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 671.91 KB

Citation

Please use this url to cite or link to this publication:

MLA
Al-Majid, Abdullah M, Muhammad Iqbal Choudhary, Sammer Yousuf, et al. “In Vitro Biological Activities of gold(I) and gold(III) bis(N-heterocyclic Carbene) Complexes.” CHEMISTRYSELECT 2.19 (2017): 5316–5320. Print.
APA
Al-Majid, A. M., Choudhary, M. I., Yousuf, S., Jabeen, A., Imad, R., Javeed, K., Shaikh, N. N., et al. (2017). In vitro biological activities of gold(I) and gold(III) bis(N-heterocyclic carbene) complexes. CHEMISTRYSELECT, 2(19), 5316–5320.
Chicago author-date
Al-Majid, Abdullah M, Muhammad Iqbal Choudhary, Sammer Yousuf, Almas Jabeen, Rehan Imad, Kulsoom Javeed, Nimra Naveed Shaikh, et al. 2017. “In Vitro Biological Activities of gold(I) and gold(III) bis(N-heterocyclic Carbene) Complexes.” Chemistryselect 2 (19): 5316–5320.
Chicago author-date (all authors)
Al-Majid, Abdullah M, Muhammad Iqbal Choudhary, Sammer Yousuf, Almas Jabeen, Rehan Imad, Kulsoom Javeed, Nimra Naveed Shaikh, Alba Collado, Eleni Sioriki, Fady Nahra, and Steven Nolan. 2017. “In Vitro Biological Activities of gold(I) and gold(III) bis(N-heterocyclic Carbene) Complexes.” Chemistryselect 2 (19): 5316–5320.
Vancouver
1.
Al-Majid AM, Choudhary MI, Yousuf S, Jabeen A, Imad R, Javeed K, et al. In vitro biological activities of gold(I) and gold(III) bis(N-heterocyclic carbene) complexes. CHEMISTRYSELECT. 2017;2(19):5316–20.
IEEE
[1]
A. M. Al-Majid et al., “In vitro biological activities of gold(I) and gold(III) bis(N-heterocyclic carbene) complexes,” CHEMISTRYSELECT, vol. 2, no. 19, pp. 5316–5320, 2017.
@article{8528487,
  abstract     = {The aim of this research is to evaluate for the first time the in vitro leishmanicidal activity and inhibition of alpha-glucosidase and beta-glucuronidase of new gold(I) and gold(III) complexes involving N-heterocyclic carbene (NHC) ligands, with the general formula [Au(X)(n)(NHC) R-2][BF4] (X= Cl, OAc, R= various aromatic and aliphatic substituents). The Au(III) complexes were shown to have a significant antileishmanial activity, and were also found to be more potent inhibitors of alpha-glucosidase and beta-glucuronidase enzymes than the standard drugs. Some complexes were also identified as potent anti-inflammatory agents with activity comparable to that of tested standard drugs, allopurinol and ibuprofen. These gold complexes were also evaluated for their in vitro cytotoxic activity against HeLa (cervical cancer), MCF-3 (breast cancer), and 3T3 (mouse fibroblast) cell lines.},
  author       = {Al-Majid, Abdullah M and Choudhary, Muhammad Iqbal and Yousuf, Sammer and Jabeen, Almas and Imad, Rehan and Javeed, Kulsoom and Shaikh, Nimra Naveed and Collado, Alba and Sioriki, Eleni and Nahra, Fady and Nolan, Steven},
  issn         = {2365-6549},
  journal      = {CHEMISTRYSELECT},
  keywords     = {Anti-inflammatory,Cytotoxicity,Enzyme inhibition,Gold complexes,N-heterocyclic carbene,ALPHA-GLUCOSIDASE INHIBITORS,ANTICANCER AGENTS,BETA-GLUCURONIDASE,THIOREDOXIN REDUCTASE,ANTITUMOR AGENTS,CANCER-CELLS,MALTASE-GLUCOAMYLASE,CYTOTOXICITY,LEISHMANIA,EXPRESSION},
  language     = {eng},
  number       = {19},
  pages        = {5316--5320},
  title        = {In vitro biological activities of gold(I) and gold(III) bis(N-heterocyclic carbene) complexes},
  url          = {http://dx.doi.org/10.1002/slct.201700795},
  volume       = {2},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: