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Limiting inflammation : the negative regulation of NF-κB and the NLRP3 inflammasome

Inna Afonina UGent, Zhenyu Zhong, Michael Karin and Rudi Beyaert UGent (2017) NATURE IMMUNOLOGY. 18(8). p.861-869
abstract
A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the 'inflammatory fire' kindled by the host response must be tightly controlled to prevent it from spreading and causing irreparable damage. Accordingly, acute inflammation is self-limiting and is normally attenuated after elimination of noxious stimuli, restoration of homeostasis and initiation of tissue repair. However, unresolved inflammation may lead to the development of chronic autoimmune and degenerative diseases and cancer. Here, we discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-kappa B pathway and the NLRP3 inflammasome. Understanding these negative regulatory mechanisms should facilitate the development of much-needed therapeutic strategies for treatment of inflammatory and autoimmune pathologies.
Please use this url to cite or link to this publication:
author
organization
alternative title
Limiting inflammation : the negative regulation of NF-kappa B and the NLRP3 inflammasome
year
type
journalArticle (review)
publication status
published
subject
keyword
ONSET AUTOINFLAMMATORY DISEASE, INNATE IMMUNE-RESPONSES, SPATA2 LINKS, CYLD, CELL-DEATH, IRAK-M, DEUBIQUITINATING ENZYME, SYSTEMIC, INFLAMMATION, MESSENGER-RNAS, I INTERFERON, TNF-ALPHA
journal title
NATURE IMMUNOLOGY
Nat. Immunol.
volume
18
issue
8
pages
861 - 869
Web of Science type
Review
Web of Science id
000405821100006
ISSN
1529-2908
1529-2916
DOI
10.1038/ni.3772
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors contributed equally to this work; the last two authors jointly directed this work
copyright statement
I have transferred the copyright for this publication to the publisher
id
8528368
handle
http://hdl.handle.net/1854/LU-8528368
date created
2017-08-07 14:59:04
date last changed
2017-10-20 09:39:09
@article{8528368,
  abstract     = {A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the 'inflammatory fire' kindled by the host response must be tightly controlled to prevent it from spreading and causing irreparable damage. Accordingly, acute inflammation is self-limiting and is normally attenuated after elimination of noxious stimuli, restoration of homeostasis and initiation of tissue repair. However, unresolved inflammation may lead to the development of chronic autoimmune and degenerative diseases and cancer. Here, we discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-kappa B pathway and the NLRP3 inflammasome. Understanding these negative regulatory mechanisms should facilitate the development of much-needed therapeutic strategies for treatment of inflammatory and autoimmune pathologies.},
  author       = {Afonina, Inna and Zhong, Zhenyu and Karin, Michael and Beyaert, Rudi},
  issn         = {1529-2908},
  journal      = {NATURE IMMUNOLOGY},
  keyword      = {ONSET AUTOINFLAMMATORY DISEASE,INNATE IMMUNE-RESPONSES,SPATA2 LINKS,CYLD,CELL-DEATH,IRAK-M,DEUBIQUITINATING ENZYME,SYSTEMIC,INFLAMMATION,MESSENGER-RNAS,I INTERFERON,TNF-ALPHA},
  language     = {eng},
  number       = {8},
  pages        = {861--869},
  title        = {Limiting inflammation : the negative regulation of NF-\ensuremath{\kappa}B and the NLRP3 inflammasome},
  url          = {http://dx.doi.org/10.1038/ni.3772},
  volume       = {18},
  year         = {2017},
}

Chicago
Afonina, Inna, Zhenyu Zhong, Michael Karin, and Rudi Beyaert. 2017. “Limiting Inflammation : the Negative Regulation of NF-κB and the NLRP3 Inflammasome.” Nature Immunology 18 (8): 861–869.
APA
Afonina, I., Zhong, Z., Karin, M., & Beyaert, R. (2017). Limiting inflammation : the negative regulation of NF-κB and the NLRP3 inflammasome. NATURE IMMUNOLOGY, 18(8), 861–869.
Vancouver
1.
Afonina I, Zhong Z, Karin M, Beyaert R. Limiting inflammation : the negative regulation of NF-κB and the NLRP3 inflammasome. NATURE IMMUNOLOGY. 2017;18(8):861–9.
MLA
Afonina, Inna, Zhenyu Zhong, Michael Karin, et al. “Limiting Inflammation : the Negative Regulation of NF-κB and the NLRP3 Inflammasome.” NATURE IMMUNOLOGY 18.8 (2017): 861–869. Print.