Advanced search
1 file | 1.29 MB

Limiting inflammation : the negative regulation of NF-κB and the NLRP3 inflammasome

(2017) NATURE IMMUNOLOGY. 18(8). p.861-869
Author
Organization
Abstract
A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the 'inflammatory fire' kindled by the host response must be tightly controlled to prevent it from spreading and causing irreparable damage. Accordingly, acute inflammation is self-limiting and is normally attenuated after elimination of noxious stimuli, restoration of homeostasis and initiation of tissue repair. However, unresolved inflammation may lead to the development of chronic autoimmune and degenerative diseases and cancer. Here, we discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-kappa B pathway and the NLRP3 inflammasome. Understanding these negative regulatory mechanisms should facilitate the development of much-needed therapeutic strategies for treatment of inflammatory and autoimmune pathologies.
Keywords
ONSET AUTOINFLAMMATORY DISEASE, INNATE IMMUNE-RESPONSES, SPATA2 LINKS, CYLD, CELL-DEATH, IRAK-M, DEUBIQUITINATING ENZYME, SYSTEMIC, INFLAMMATION, MESSENGER-RNAS, I INTERFERON, TNF-ALPHA

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.29 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Afonina, Inna, Zhenyu Zhong, Michael Karin, and Rudi Beyaert. 2017. “Limiting Inflammation : the Negative Regulation of NF-κB and the NLRP3 Inflammasome.” Nature Immunology 18 (8): 861–869.
APA
Afonina, I., Zhong, Z., Karin, M., & Beyaert, R. (2017). Limiting inflammation : the negative regulation of NF-κB and the NLRP3 inflammasome. NATURE IMMUNOLOGY, 18(8), 861–869.
Vancouver
1.
Afonina I, Zhong Z, Karin M, Beyaert R. Limiting inflammation : the negative regulation of NF-κB and the NLRP3 inflammasome. NATURE IMMUNOLOGY. 2017;18(8):861–9.
MLA
Afonina, Inna, Zhenyu Zhong, Michael Karin, et al. “Limiting Inflammation : the Negative Regulation of NF-κB and the NLRP3 Inflammasome.” NATURE IMMUNOLOGY 18.8 (2017): 861–869. Print.
@article{8528368,
  abstract     = {A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the 'inflammatory fire' kindled by the host response must be tightly controlled to prevent it from spreading and causing irreparable damage. Accordingly, acute inflammation is self-limiting and is normally attenuated after elimination of noxious stimuli, restoration of homeostasis and initiation of tissue repair. However, unresolved inflammation may lead to the development of chronic autoimmune and degenerative diseases and cancer. Here, we discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-kappa B pathway and the NLRP3 inflammasome. Understanding these negative regulatory mechanisms should facilitate the development of much-needed therapeutic strategies for treatment of inflammatory and autoimmune pathologies.},
  author       = {Afonina, Inna and Zhong, Zhenyu and Karin, Michael and Beyaert, Rudi},
  issn         = {1529-2908},
  journal      = {NATURE IMMUNOLOGY},
  keyword      = {ONSET AUTOINFLAMMATORY DISEASE,INNATE IMMUNE-RESPONSES,SPATA2 LINKS,CYLD,CELL-DEATH,IRAK-M,DEUBIQUITINATING ENZYME,SYSTEMIC,INFLAMMATION,MESSENGER-RNAS,I INTERFERON,TNF-ALPHA},
  language     = {eng},
  number       = {8},
  pages        = {861--869},
  title        = {Limiting inflammation : the negative regulation of NF-\ensuremath{\kappa}B and the NLRP3 inflammasome},
  url          = {http://dx.doi.org/10.1038/ni.3772},
  volume       = {18},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: