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Antibody persistence and booster responses to split-virion H5N1 avian influenza vaccine in young and elderly adults

Rajeka Lazarus, Sarah Kelly, Matthew D Snape, Corinne Vandermeulen, Merryn Voysey, Karel Hoppenbrouwers, Annick Hens, Pierre Van Damme, Stephanie Pepin, Isabel Leroux-Roels UGent, et al. (2016) PLOS ONE. 11(11).
abstract
Avian influenza continues to circulate and remains a global health threat not least because of the associated high mortality. In this study antibody persistence, booster vaccine response and cross-clade immune response between two influenza A(H5N1) vaccines were compared. Participants aged over 18-years who had previously been immunized with a clade 1, A/Vietnam vaccine were re-immunized at 6-months with 7.5 mu g of the homologous strain or at 22-months with a clade 2, alum-adjuvanted, A/Indonesia vaccine. Blood sampled at 6, 15 and 22-months after the primary course was used to assess antibody persistence. Antibody concentrations 6-months after primary immunisation with either A/Vietnam vaccine 30 mu g alum-adjuvanted vaccine or 7.5 mu g dose vaccine were lower than 21days after the primary course and waned further with time. Re-immunization with the clade 2, 30 mu g alum-adjuvanted vaccine confirmed cross-clade reactogenicity. Antibody crossreactivity between A(H5N1) clades suggests that in principle a prime-boost vaccination strategy may provide both early protection at the start of a pandemic and improved antibody responses to specific vaccination once available.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
RANDOMIZED-TRIAL, IMMUNOGENICITY, SAFETY, IMMUNITY
journal title
PLOS ONE
PLoS One
volume
11
issue
11
article number
e0165384
pages
13 pages
Web of Science type
Article
Web of Science id
000386911100010
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
2.806 (2016)
JCR rank
15/64 (2016)
JCR quartile
1 (2016)
ISSN
1932-6203
DOI
10.1371/journal.pone.0165384
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
8528350
handle
http://hdl.handle.net/1854/LU-8528350
date created
2017-08-07 14:32:42
date last changed
2017-10-05 10:01:37
@article{8528350,
  abstract     = {Avian influenza continues to circulate and remains a global health threat not least because of the associated high mortality. In this study antibody persistence, booster vaccine response and cross-clade immune response between two influenza A(H5N1) vaccines were compared. Participants aged over 18-years who had previously been immunized with a clade 1, A/Vietnam vaccine were re-immunized at 6-months with 7.5 mu g of the homologous strain or at 22-months with a clade 2, alum-adjuvanted, A/Indonesia vaccine. Blood sampled at 6, 15 and 22-months after the primary course was used to assess antibody persistence. Antibody concentrations 6-months after primary immunisation with either A/Vietnam vaccine 30 mu g alum-adjuvanted vaccine or 7.5 mu g dose vaccine were lower than 21days after the primary course and waned further with time. Re-immunization with the clade 2, 30 mu g alum-adjuvanted vaccine confirmed cross-clade reactogenicity. Antibody crossreactivity between A(H5N1) clades suggests that in principle a prime-boost vaccination strategy may provide both early protection at the start of a pandemic and improved antibody responses to specific vaccination once available.},
  articleno    = {e0165384},
  author       = {Lazarus, Rajeka and Kelly, Sarah and Snape, Matthew D and Vandermeulen, Corinne and Voysey, Merryn and Hoppenbrouwers, Karel and Hens, Annick and Van Damme, Pierre and Pepin, Stephanie and Leroux-Roels, Isabel and Leroux-Roels, Geert and Pollard, Andrew J},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {RANDOMIZED-TRIAL,IMMUNOGENICITY,SAFETY,IMMUNITY},
  language     = {eng},
  number       = {11},
  pages        = {13},
  title        = {Antibody persistence and booster responses to split-virion H5N1 avian influenza vaccine in young and elderly adults},
  url          = {http://dx.doi.org/10.1371/journal.pone.0165384},
  volume       = {11},
  year         = {2016},
}

Chicago
Lazarus, Rajeka, Sarah Kelly, Matthew D Snape, Corinne Vandermeulen, Merryn Voysey, Karel Hoppenbrouwers, Annick Hens, et al. 2016. “Antibody Persistence and Booster Responses to Split-virion H5N1 Avian Influenza Vaccine in Young and Elderly Adults.” Plos One 11 (11).
APA
Lazarus, R., Kelly, S., Snape, M. D., Vandermeulen, C., Voysey, M., Hoppenbrouwers, K., Hens, A., et al. (2016). Antibody persistence and booster responses to split-virion H5N1 avian influenza vaccine in young and elderly adults. PLOS ONE, 11(11).
Vancouver
1.
Lazarus R, Kelly S, Snape MD, Vandermeulen C, Voysey M, Hoppenbrouwers K, et al. Antibody persistence and booster responses to split-virion H5N1 avian influenza vaccine in young and elderly adults. PLOS ONE. 2016;11(11).
MLA
Lazarus, Rajeka, Sarah Kelly, Matthew D Snape, et al. “Antibody Persistence and Booster Responses to Split-virion H5N1 Avian Influenza Vaccine in Young and Elderly Adults.” PLOS ONE 11.11 (2016): n. pag. Print.