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Antibody persistence and booster responses to split-virion H5N1 avian influenza vaccine in young and elderly adults

(2016) PLOS ONE. 11(11).
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Abstract
Avian influenza continues to circulate and remains a global health threat not least because of the associated high mortality. In this study antibody persistence, booster vaccine response and cross-clade immune response between two influenza A(H5N1) vaccines were compared. Participants aged over 18-years who had previously been immunized with a clade 1, A/Vietnam vaccine were re-immunized at 6-months with 7.5 mu g of the homologous strain or at 22-months with a clade 2, alum-adjuvanted, A/Indonesia vaccine. Blood sampled at 6, 15 and 22-months after the primary course was used to assess antibody persistence. Antibody concentrations 6-months after primary immunisation with either A/Vietnam vaccine 30 mu g alum-adjuvanted vaccine or 7.5 mu g dose vaccine were lower than 21days after the primary course and waned further with time. Re-immunization with the clade 2, 30 mu g alum-adjuvanted vaccine confirmed cross-clade reactogenicity. Antibody crossreactivity between A(H5N1) clades suggests that in principle a prime-boost vaccination strategy may provide both early protection at the start of a pandemic and improved antibody responses to specific vaccination once available.
Keywords
RANDOMIZED-TRIAL, IMMUNOGENICITY, SAFETY, IMMUNITY

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Citation

Please use this url to cite or link to this publication:

Chicago
Lazarus, Rajeka, Sarah Kelly, Matthew D Snape, Corinne Vandermeulen, Merryn Voysey, Karel Hoppenbrouwers, Annick Hens, et al. 2016. “Antibody Persistence and Booster Responses to Split-virion H5N1 Avian Influenza Vaccine in Young and Elderly Adults.” Plos One 11 (11).
APA
Lazarus, R., Kelly, S., Snape, M. D., Vandermeulen, C., Voysey, M., Hoppenbrouwers, K., Hens, A., et al. (2016). Antibody persistence and booster responses to split-virion H5N1 avian influenza vaccine in young and elderly adults. PLOS ONE, 11(11).
Vancouver
1.
Lazarus R, Kelly S, Snape MD, Vandermeulen C, Voysey M, Hoppenbrouwers K, et al. Antibody persistence and booster responses to split-virion H5N1 avian influenza vaccine in young and elderly adults. PLOS ONE. 2016;11(11).
MLA
Lazarus, Rajeka, Sarah Kelly, Matthew D Snape, et al. “Antibody Persistence and Booster Responses to Split-virion H5N1 Avian Influenza Vaccine in Young and Elderly Adults.” PLOS ONE 11.11 (2016): n. pag. Print.
@article{8528350,
  abstract     = {Avian influenza continues to circulate and remains a global health threat not least because of the associated high mortality. In this study antibody persistence, booster vaccine response and cross-clade immune response between two influenza A(H5N1) vaccines were compared. Participants aged over 18-years who had previously been immunized with a clade 1, A/Vietnam vaccine were re-immunized at 6-months with 7.5 mu g of the homologous strain or at 22-months with a clade 2, alum-adjuvanted, A/Indonesia vaccine. Blood sampled at 6, 15 and 22-months after the primary course was used to assess antibody persistence. Antibody concentrations 6-months after primary immunisation with either A/Vietnam vaccine 30 mu g alum-adjuvanted vaccine or 7.5 mu g dose vaccine were lower than 21days after the primary course and waned further with time. Re-immunization with the clade 2, 30 mu g alum-adjuvanted vaccine confirmed cross-clade reactogenicity. Antibody crossreactivity between A(H5N1) clades suggests that in principle a prime-boost vaccination strategy may provide both early protection at the start of a pandemic and improved antibody responses to specific vaccination once available.},
  articleno    = {e0165384},
  author       = {Lazarus, Rajeka and Kelly, Sarah and Snape, Matthew D and Vandermeulen, Corinne and Voysey, Merryn and Hoppenbrouwers, Karel and Hens, Annick and Van Damme, Pierre and Pepin, Stephanie and Leroux-Roels, Isabel and Leroux-Roels, Geert and Pollard, Andrew J},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {RANDOMIZED-TRIAL,IMMUNOGENICITY,SAFETY,IMMUNITY},
  language     = {eng},
  number       = {11},
  pages        = {13},
  title        = {Antibody persistence and booster responses to split-virion H5N1 avian influenza vaccine in young and elderly adults},
  url          = {http://dx.doi.org/10.1371/journal.pone.0165384},
  volume       = {11},
  year         = {2016},
}

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