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European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

(2017) REDOX BIOLOGY. 13. p.94-162
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Abstract
The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.
Keywords
Reactive oxygen species, Reactive nitrogen species, Redox signaling, Oxidative stress, Antioxidants, Redox therapeutics, NITRIC-OXIDE SYNTHASE, CHRONIC GRANULOMATOUS-DISEASE, MITOCHONDRIAL OXIDATIVE STRESS, SMOOTH-MUSCLE-CELLS, MANGANESE SUPEROXIDE-DISMUTASE, ENDOPLASMIC-RETICULUM STRESS, ISCHEMIA-REPERFUSION INJURY, TANDEM MASS-SPECTROMETRY, GROWTH-FACTOR-BETA, PULMONARY ARTERIAL-HYPERTENSION

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Citation

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MLA
Egea, Javier et al. “European Contribution to the Study of ROS : a Summary of the Findings and Prospects for the Future from the COST Action BM1203 (EU-ROS).” REDOX BIOLOGY 13 (2017): 94–162. Print.
APA
Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., et al. (2017). European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). REDOX BIOLOGY, 13, 94–162.
Chicago author-date
Egea, Javier, Isabel Fabregat, Yves M Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, et al. 2017. “European Contribution to the Study of ROS : a Summary of the Findings and Prospects for the Future from the COST Action BM1203 (EU-ROS).” Redox Biology 13: 94–162.
Chicago author-date (all authors)
Egea, Javier, Isabel Fabregat, Yves M Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G Knaus, Manuela G Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S Ademowo, Catarina B Afonso, Ioanna Andreadou, Haike Antelmann, Fernando Antunes, Mutay Aslan, Markus M Bachschmid, Rui M Barbosa, Vsevolod Belousov, Carsten Berndt, David Bernlohr, Esther Bertrán, Alberto Bindoli, Serge P Bottari, Paula M Brito, Guia Carrara, Ana I Casas, Afroditi Chatzi, Niki Chondrogianni, Marcus Conrad, Marcus S Cooke, João G Costa, Antonio Cuadrado, Pham My-Chan Dang, Barbara De Smet, Bilge Debelec–Butuner, Irundika HK Dias, Joe Dan Dunn, Amanda J Edson, Mariam El Assar, Jamel El-Benna, Péter Ferdinandy, Ana S Fernandes, Kari E Fladmark, Ulrich Förstermann, Rashid Giniatullin, Zoltán Giricz, Anikó Görbe, Helen Griffiths, Vaclav Hampl, Alina Hanf, Jan Herget, Pablo Hernansanz-Agustín, Melanie Hillion, Jingjing Huang, Serap Ilikay, Pidder Jansen-Dürr, Vincent Jaquet, Jaap A Joles, Balaraman Kalyanaraman, Danylo Kaminskyy, Mahsa Karbaschi, Marina Kleanthous, Lars-Oliver Klotz, Bato Korac, Kemal Sami Korkmaz, Rafal Koziel, Damir Kračun, Karl-Heinz Krause, Vladimír Křen, Thomas Krieg, João Laranjinha, Antigone Lazou, Huige Li, Antonio Martínez-Ruiz, Reiko Matsui, Gethin J McBean, Stuart P Meredith, Joris Messens, Verónica Miguel, Yuliya Mikhed, Irina Milisav, Lidija Milković, Antonio Miranda-Vizuete, Miloš Mojović, María Monsalve, Pierre-Alexis Mouthuy, John Mulvey, Thomas Münzel, Vladimir Muzykantov, Isabel TN Nguyen, Matthias Oelze, Nuno G Oliveira, Carlos M Palmeira, Nikoletta Papaevgeniou, Aleksandra Pavićević, Brandán Pedre, Fabienne Peyrot, Marios Phylactides, Gratiela G Pircalabioru, Andrew R Pitt, Henrik E Poulsen, Ignacio Prieto, Maria Pia Rigobello, Natalia Robledinos-Antón, Leocadio Rodríguez-Mañas, Anabela P Rolo, Francis Rousset, Tatjana Ruskovska, Nuno Saraiva, Shlomo Sasson, Katrin Schröder, Khrystyna Semen, Tamara Seredenina, Anastasia Shakirzyanova, Geoffrey L Smith, Thierry Soldati, Bebiana C Sousa, Corinne M Spickett, Ana Stancic, Marie José Stasia, Holger Steinbrenner, Višnja Stepanić, Sebastian Steven, Kostas Tokatlidis, Erkan Tuncay, Belma Turan, Fulvio Ursini, Jan Vacek, Olga Vajnerova, Kateřina Valentová, Frank Van Breusegem, Lokman Varisli, Elizabeth A Veal, A Suha Yalçın, Olha Yelisyeyeva, Neven Žarković, Martina Zatloukalová, Jacek Zielonka, Rhian M Touyz, Andreas Papapetropoulos, Tilman Grune, Santiago Lamas, Harald HHW Schmidt, Fabio Di Lisa, and Andreas Daiber. 2017. “European Contribution to the Study of ROS : a Summary of the Findings and Prospects for the Future from the COST Action BM1203 (EU-ROS).” Redox Biology 13: 94–162.
Vancouver
1.
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, et al. European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). REDOX BIOLOGY. 2017;13:94–162.
IEEE
[1]
J. Egea et al., “European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS),” REDOX BIOLOGY, vol. 13, pp. 94–162, 2017.
@article{8528221,
  abstract     = {{The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.}},
  author       = {{Egea, Javier and Fabregat, Isabel and Frapart, Yves M and Ghezzi, Pietro and Görlach, Agnes and Kietzmann, Thomas and Kubaichuk, Kateryna and Knaus, Ulla G and Lopez, Manuela G and Olaso-Gonzalez, Gloria and Petry, Andreas and Schulz, Rainer and Vina, Jose and Winyard, Paul and Abbas, Kahina and Ademowo, Opeyemi S and Afonso, Catarina B and Andreadou, Ioanna and Antelmann, Haike and Antunes, Fernando and Aslan, Mutay and Bachschmid, Markus M and Barbosa, Rui M and Belousov, Vsevolod and Berndt, Carsten and Bernlohr, David and Bertrán, Esther and Bindoli, Alberto and Bottari, Serge P and Brito, Paula M and Carrara, Guia and Casas, Ana I and Chatzi, Afroditi and Chondrogianni, Niki and Conrad, Marcus and Cooke, Marcus S and Costa, João G and Cuadrado, Antonio and My-Chan Dang, Pham and De Smet, Barbara and Debelec–Butuner, Bilge and Dias, Irundika HK and Dunn, Joe Dan and Edson, Amanda J and El Assar, Mariam and El-Benna, Jamel and Ferdinandy, Péter and Fernandes, Ana S and Fladmark, Kari E and Förstermann, Ulrich and Giniatullin, Rashid and Giricz, Zoltán and Görbe, Anikó and Griffiths, Helen and Hampl, Vaclav and Hanf, Alina and Herget, Jan and Hernansanz-Agustín, Pablo and Hillion, Melanie and Huang, Jingjing and Ilikay, Serap and Jansen-Dürr, Pidder and Jaquet, Vincent and Joles, Jaap A and Kalyanaraman, Balaraman and Kaminskyy, Danylo and Karbaschi, Mahsa and Kleanthous, Marina and Klotz, Lars-Oliver and Korac, Bato and Korkmaz, Kemal Sami and Koziel, Rafal and Kračun, Damir and Krause, Karl-Heinz and Křen, Vladimír and Krieg, Thomas and Laranjinha, João and Lazou, Antigone and Li, Huige and Martínez-Ruiz, Antonio and Matsui, Reiko and McBean, Gethin J and Meredith, Stuart P and Messens, Joris and Miguel, Verónica and Mikhed, Yuliya and Milisav, Irina and Milković, Lidija and Miranda-Vizuete, Antonio and Mojović, Miloš and Monsalve, María and Mouthuy, Pierre-Alexis and Mulvey, John and Münzel, Thomas and Muzykantov, Vladimir and Nguyen, Isabel TN and Oelze, Matthias and Oliveira, Nuno G and Palmeira, Carlos M and Papaevgeniou, Nikoletta and Pavićević, Aleksandra and Pedre, Brandán and Peyrot, Fabienne and Phylactides, Marios and Pircalabioru, Gratiela G and Pitt, Andrew R and Poulsen, Henrik E and Prieto, Ignacio and Rigobello, Maria Pia and Robledinos-Antón, Natalia and Rodríguez-Mañas, Leocadio and Rolo, Anabela P and Rousset, Francis and Ruskovska, Tatjana and Saraiva, Nuno and Sasson, Shlomo and Schröder, Katrin and Semen, Khrystyna and Seredenina, Tamara and Shakirzyanova, Anastasia and Smith, Geoffrey L and Soldati, Thierry and Sousa, Bebiana C and Spickett, Corinne M and Stancic, Ana and Stasia, Marie José and Steinbrenner, Holger and Stepanić, Višnja and Steven, Sebastian and Tokatlidis, Kostas and Tuncay, Erkan and Turan, Belma and Ursini, Fulvio and Vacek, Jan and Vajnerova, Olga and Valentová, Kateřina and Van Breusegem, Frank and Varisli, Lokman and Veal, Elizabeth A and Yalçın, A Suha and Yelisyeyeva, Olha and Žarković, Neven and Zatloukalová, Martina and Zielonka, Jacek and Touyz, Rhian M and Papapetropoulos, Andreas and Grune, Tilman and Lamas, Santiago and Schmidt, Harald HHW and Di Lisa, Fabio and Daiber, Andreas}},
  issn         = {{2213-2317}},
  journal      = {{REDOX BIOLOGY}},
  keywords     = {{Reactive oxygen species,Reactive nitrogen species,Redox signaling,Oxidative stress,Antioxidants,Redox therapeutics,NITRIC-OXIDE SYNTHASE,CHRONIC GRANULOMATOUS-DISEASE,MITOCHONDRIAL OXIDATIVE STRESS,SMOOTH-MUSCLE-CELLS,MANGANESE SUPEROXIDE-DISMUTASE,ENDOPLASMIC-RETICULUM STRESS,ISCHEMIA-REPERFUSION INJURY,TANDEM MASS-SPECTROMETRY,GROWTH-FACTOR-BETA,PULMONARY ARTERIAL-HYPERTENSION}},
  language     = {{eng}},
  pages        = {{94--162}},
  title        = {{European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)}},
  url          = {{http://dx.doi.org/10.1016/j.redox.2017.05.007}},
  volume       = {{13}},
  year         = {{2017}},
}

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