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European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Javier Egea, Isabel Fabregat, Yves M Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G Knaus, Manuela G Lopez, Gloria Olaso-Gonzalez, et al. (2017) REDOX BIOLOGY. 13. p.94-162
abstract
The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
Reactive oxygen species, Reactive nitrogen species, Redox signaling, Oxidative stress, Antioxidants, Redox therapeutics, NITRIC-OXIDE SYNTHASE, CHRONIC GRANULOMATOUS-DISEASE, MITOCHONDRIAL OXIDATIVE STRESS, SMOOTH-MUSCLE-CELLS, MANGANESE SUPEROXIDE-DISMUTASE, ENDOPLASMIC-RETICULUM STRESS, ISCHEMIA-REPERFUSION INJURY, TANDEM MASS-SPECTROMETRY, GROWTH-FACTOR-BETA, PULMONARY ARTERIAL-HYPERTENSION
journal title
REDOX BIOLOGY
Redox Biol.
volume
13
pages
94 - 162
Web of Science type
Review
Web of Science id
000410470000009
ISSN
2213-2317
DOI
10.1016/j.redox.2017.05.007
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
additional info
correction [of acknowledgement] published in: Redox Biol. (2018) 14, 694-696 ; DOI: 10.1016/j.redox.2017.10.001
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8528221
handle
http://hdl.handle.net/1854/LU-8528221
date created
2017-08-04 13:50:31
date last changed
2018-03-22 13:04:55
@article{8528221,
  abstract     = {The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.},
  author       = {Egea, Javier and Fabregat, Isabel and Frapart, Yves M and Ghezzi, Pietro and G{\"o}rlach, Agnes and Kietzmann, Thomas and Kubaichuk, Kateryna and Knaus, Ulla G and Lopez, Manuela G and Olaso-Gonzalez, Gloria and Petry, Andreas and Schulz, Rainer and Vina, Jose and Winyard, Paul and Abbas, Kahina and Ademowo, Opeyemi S and Afonso, Catarina B and Andreadou, Ioanna and Antelmann, Haike and Antunes, Fernando and Aslan, Mutay and Bachschmid, Markus M and Barbosa, Rui M and Belousov, Vsevolod and Berndt, Carsten and Bernlohr, David and Bertr{\'a}n, Esther and Bindoli, Alberto and Bottari, Serge P and Brito, Paula M and Carrara, Guia and Casas, Ana I and Chatzi, Afroditi and Chondrogianni, Niki and Conrad, Marcus and Cooke, Marcus S and Costa, Jo{\~a}o G and Cuadrado, Antonio and My-Chan Dang, Pham and De Smet, Barbara and Debelec--Butuner, Bilge and Dias, Irundika HK and Dunn, Joe Dan and Edson, Amanda J and El Assar, Mariam and El-Benna, Jamel and Ferdinandy, P{\'e}ter and Fernandes, Ana S and Fladmark, Kari E and F{\"o}rstermann, Ulrich and Giniatullin, Rashid and Giricz, Zolt{\'a}n and G{\"o}rbe, Anik{\'o} and Griffiths, Helen and Hampl, Vaclav and Hanf, Alina and Herget, Jan and Hernansanz-Agust{\'i}n, Pablo and Hillion, Melanie and Huang, Jingjing and Ilikay, Serap and Jansen-D{\"u}rr, Pidder and Jaquet, Vincent and Joles, Jaap A and Kalyanaraman, Balaraman and Kaminskyy, Danylo and Karbaschi, Mahsa and Kleanthous, Marina and Klotz, Lars-Oliver and Korac, Bato and Korkmaz, Kemal Sami and Koziel, Rafal and Kra\v{c}un, Damir and Krause, Karl-Heinz and K\v{r}en, Vladim{\'i}r and Krieg, Thomas and Laranjinha, Jo{\~a}o and Lazou, Antigone and Li, Huige and Mart{\'i}nez-Ruiz, Antonio and Matsui, Reiko and McBean, Gethin J and Meredith, Stuart P and Messens, Joris and Miguel, Ver{\'o}nica and Mikhed, Yuliya and Milisav, Irina and Milkovi\'{c}, Lidija and Miranda-Vizuete, Antonio and Mojovi\'{c}, Milo\v{s} and Monsalve, Mar{\'i}a and Mouthuy, Pierre-Alexis and Mulvey, John and M{\"u}nzel, Thomas and Muzykantov, Vladimir and Nguyen, Isabel TN and Oelze, Matthias and Oliveira, Nuno G and Palmeira, Carlos M and Papaevgeniou, Nikoletta and Pavi\'{c}evi\'{c}, Aleksandra and Pedre, Brand{\'a}n and Peyrot, Fabienne and Phylactides, Marios and Pircalabioru, Gratiela G and Pitt, Andrew R and Poulsen, Henrik E and Prieto, Ignacio and Rigobello, Maria Pia and Robledinos-Ant{\'o}n, Natalia and Rodr{\'i}guez-Ma{\~n}as, Leocadio and Rolo, Anabela P and Rousset, Francis and Ruskovska, Tatjana and Saraiva, Nuno and Sasson, Shlomo and Schr{\"o}der, Katrin and Semen, Khrystyna and Seredenina, Tamara and Shakirzyanova, Anastasia and Smith, Geoffrey L and Soldati, Thierry and Sousa, Bebiana C and Spickett, Corinne M and Stancic, Ana and Stasia, Marie Jos{\'e} and Steinbrenner, Holger and Stepani\'{c}, Vi\v{s}nja and Steven, Sebastian and Tokatlidis, Kostas and Tuncay, Erkan and Turan, Belma and Ursini, Fulvio and Vacek, Jan and Vajnerova, Olga and Valentov{\'a}, Kate\v{r}ina and Van Breusegem, Frank and Varisli, Lokman and Veal, Elizabeth A and Yal\c{c}{\i}n, A Suha and Yelisyeyeva, Olha and \v{Z}arkovi\'{c}, Neven and Zatloukalov{\'a}, Martina and Zielonka, Jacek and Touyz, Rhian M and Papapetropoulos, Andreas and Grune, Tilman and Lamas, Santiago and Schmidt, Harald HHW and Di Lisa, Fabio and Daiber, Andreas},
  issn         = {2213-2317},
  journal      = {REDOX BIOLOGY},
  keyword      = {Reactive oxygen species,Reactive nitrogen species,Redox signaling,Oxidative stress,Antioxidants,Redox therapeutics,NITRIC-OXIDE SYNTHASE,CHRONIC GRANULOMATOUS-DISEASE,MITOCHONDRIAL OXIDATIVE STRESS,SMOOTH-MUSCLE-CELLS,MANGANESE SUPEROXIDE-DISMUTASE,ENDOPLASMIC-RETICULUM STRESS,ISCHEMIA-REPERFUSION INJURY,TANDEM MASS-SPECTROMETRY,GROWTH-FACTOR-BETA,PULMONARY ARTERIAL-HYPERTENSION},
  language     = {eng},
  pages        = {94--162},
  title        = {European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)},
  url          = {http://dx.doi.org/10.1016/j.redox.2017.05.007},
  volume       = {13},
  year         = {2017},
}

Chicago
Egea, Javier, Isabel Fabregat, Yves M Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, et al. 2017. “European Contribution to the Study of ROS : a Summary of the Findings and Prospects for the Future from the COST Action BM1203 (EU-ROS).” Redox Biology 13: 94–162.
APA
Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., et al. (2017). European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). REDOX BIOLOGY, 13, 94–162.
Vancouver
1.
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, et al. European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). REDOX BIOLOGY. 2017;13:94–162.
MLA
Egea, Javier, Isabel Fabregat, Yves M Frapart, et al. “European Contribution to the Study of ROS : a Summary of the Findings and Prospects for the Future from the COST Action BM1203 (EU-ROS).” REDOX BIOLOGY 13 (2017): 94–162. Print.