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Iron isotopic composition of blood serum in anemia of chronic kidney disease

Yulia Anoshkina (UGent) , Marta Costas Rodriguez (UGent) , Marijn Speeckaert (UGent) , Wim Van Biesen (UGent) , Joris Delanghe (UGent) and Frank Vanhaecke (UGent)
(2017) METALLOMICS. 9(5). p.517-524
Author
Organization
Abstract
Chronic kidney disease (CKD) is a general term for disorders that affect the structure and function of the kidneys. Iron deficiency (ID) and anemia occur in the vast majority of CKD patients, most of whom are elderly. However, establishing the cause of anemia in CKD, and therefore making an informed decision concerning the corresponding therapeutic treatment, is still a challenge. High-precision Fe isotopic analysis of blood serum samples of CKD patients with and without ID/anemia was performed via multi-collector inductively coupled plasma-mass spectrometry (MC-ICP-MS) for such a purpose. Patients with CKD and/or iron disorders showed a heavier serum Fe isotopic composition than controls. Many clinical parameters used for the diagnosis and follow-up of anemia correlated significantly with the serum Fe isotopic composition. In contrast, no relation was observed between the serum Fe isotopic composition and the estimated glomerular filtration rate as a measure of kidney function. Among the CKD patients, the serum Fe isotopic composition was substantially heavier in the occurrence of ID anemia, while erythropoietin-related anemia did not exert this effect. The Fe isotopic composition can thus be useful for distinguishing these different types of anemias in CKD patients, i.e. ID anemia vs. erythropoietin-related anemia.
Keywords
ICP-MASS SPECTROMETRY, DEFICIENCY ANEMIA, TRANSFERRIN RECEPTOR, HEREDITARY HEMOCHROMATOSIS, GLOMERULAR-FILTRATION, DIAGNOSIS, FERRITIN, INJURY, RATIO, HEPCIDIN

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Citation

Please use this url to cite or link to this publication:

MLA
Anoshkina, Yulia, et al. “Iron Isotopic Composition of Blood Serum in Anemia of Chronic Kidney Disease.” METALLOMICS, vol. 9, no. 5, 2017, pp. 517–24.
APA
Anoshkina, Y., Costas Rodriguez, M., Speeckaert, M., Van Biesen, W., Delanghe, J., & Vanhaecke, F. (2017). Iron isotopic composition of blood serum in anemia of chronic kidney disease. METALLOMICS, 9(5), 517–524.
Chicago author-date
Anoshkina, Yulia, Marta Costas Rodriguez, Marijn Speeckaert, Wim Van Biesen, Joris Delanghe, and Frank Vanhaecke. 2017. “Iron Isotopic Composition of Blood Serum in Anemia of Chronic Kidney Disease.” METALLOMICS 9 (5): 517–24.
Chicago author-date (all authors)
Anoshkina, Yulia, Marta Costas Rodriguez, Marijn Speeckaert, Wim Van Biesen, Joris Delanghe, and Frank Vanhaecke. 2017. “Iron Isotopic Composition of Blood Serum in Anemia of Chronic Kidney Disease.” METALLOMICS 9 (5): 517–524.
Vancouver
1.
Anoshkina Y, Costas Rodriguez M, Speeckaert M, Van Biesen W, Delanghe J, Vanhaecke F. Iron isotopic composition of blood serum in anemia of chronic kidney disease. METALLOMICS. 2017;9(5):517–24.
IEEE
[1]
Y. Anoshkina, M. Costas Rodriguez, M. Speeckaert, W. Van Biesen, J. Delanghe, and F. Vanhaecke, “Iron isotopic composition of blood serum in anemia of chronic kidney disease,” METALLOMICS, vol. 9, no. 5, pp. 517–524, 2017.
@article{8528209,
  abstract     = {Chronic kidney disease (CKD) is a general term for disorders that affect the structure and function of the kidneys. Iron deficiency (ID) and anemia occur in the vast majority of CKD patients, most of whom are elderly. However, establishing the cause of anemia in CKD, and therefore making an informed decision concerning the corresponding therapeutic treatment, is still a challenge. High-precision Fe isotopic analysis of blood serum samples of CKD patients with and without ID/anemia was performed via multi-collector inductively coupled plasma-mass spectrometry (MC-ICP-MS) for such a purpose. Patients with CKD and/or iron disorders showed a heavier serum Fe isotopic composition than controls. Many clinical parameters used for the diagnosis and follow-up of anemia correlated significantly with the serum Fe isotopic composition. In contrast, no relation was observed between the serum Fe isotopic composition and the estimated glomerular filtration rate as a measure of kidney function. Among the CKD patients, the serum Fe isotopic composition was substantially heavier in the occurrence of ID anemia, while erythropoietin-related anemia did not exert this effect. The Fe isotopic composition can thus be useful for distinguishing these different types of anemias in CKD patients, i.e. ID anemia vs. erythropoietin-related anemia.},
  author       = {Anoshkina, Yulia and Costas Rodriguez, Marta and Speeckaert, Marijn and Van Biesen, Wim and Delanghe, Joris and Vanhaecke, Frank},
  issn         = {1756-5901},
  journal      = {METALLOMICS},
  keywords     = {ICP-MASS SPECTROMETRY,DEFICIENCY ANEMIA,TRANSFERRIN RECEPTOR,HEREDITARY HEMOCHROMATOSIS,GLOMERULAR-FILTRATION,DIAGNOSIS,FERRITIN,INJURY,RATIO,HEPCIDIN},
  language     = {eng},
  number       = {5},
  pages        = {517--524},
  title        = {Iron isotopic composition of blood serum in anemia of chronic kidney disease},
  url          = {http://dx.doi.org/10.1039/c7mt00021a},
  volume       = {9},
  year         = {2017},
}

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