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Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection

(2016) PARASITE IMMUNOLOGY. 38(10). p.642-647
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Abstract
African trypanosomosis is a debilitating parasitic disease occurring in large parts of sub-Saharan Africa. Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing disease. Multiple experimental murine models for trypanosomosis have demonstrated inflammation-dependent apoptosis of splenic follicular B (FoB) cells and the destruction of B-cell memory against previously encountered pathogens. Here, we report that during murine infection with a chronic T.b.gambiense field isolate, FoB cells are retained. This coincided with reduced levels of IFN- and TNF- during the acute phase of the infection. This result suggests that in chronic infections with low virulent parasites, less inflammation is elicited and consequently no FoB cell destruction occurs.
Keywords
B lymphocyte, inflammation, Trypanosoma spp, trypanosomiasis, HUMAN AFRICAN TRYPANOSOMIASIS, IMMUNE-RESPONSE, MICE, RHODESIENSE

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Chicago
Cnops, J, F Kauffmann, C De Trez, T Baltz, J Keirsse, Magdalena Radwanska, E Muraille, and Stefan Magez. 2016. “Maintenance of B Cells During Chronic Murine Trypanosoma Brucei Gambiense Infection.” Parasite Immunology 38 (10): 642–647.
APA
Cnops, J, Kauffmann, F., De Trez, C., Baltz, T., Keirsse, J., Radwanska, M., Muraille, E., et al. (2016). Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection. PARASITE IMMUNOLOGY, 38(10), 642–647.
Vancouver
1.
Cnops J, Kauffmann F, De Trez C, Baltz T, Keirsse J, Radwanska M, et al. Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection. PARASITE IMMUNOLOGY. 2016;38(10):642–7.
MLA
Cnops, J, F Kauffmann, C De Trez, et al. “Maintenance of B Cells During Chronic Murine Trypanosoma Brucei Gambiense Infection.” PARASITE IMMUNOLOGY 38.10 (2016): 642–647. Print.
@article{8528055,
  abstract     = {African trypanosomosis is a debilitating parasitic disease occurring in large parts of sub-Saharan Africa. Trypanosoma brucei gambiense accounts for 98\% of the reported HAT infections and causes a chronic, gradually progressing disease. Multiple experimental murine models for trypanosomosis have demonstrated inflammation-dependent apoptosis of splenic follicular B (FoB) cells and the destruction of B-cell memory against previously encountered pathogens. Here, we report that during murine infection with a chronic T.b.gambiense field isolate, FoB cells are retained. This coincided with reduced levels of IFN- and TNF- during the acute phase of the infection. This result suggests that in chronic infections with low virulent parasites, less inflammation is elicited and consequently no FoB cell destruction occurs.},
  author       = {Cnops, J and Kauffmann, F and De Trez, C and Baltz, T and Keirsse, J and Radwanska, Magdalena and Muraille, E and Magez, Stefan},
  issn         = {0141-9838},
  journal      = {PARASITE IMMUNOLOGY},
  keyword      = {B lymphocyte,inflammation,Trypanosoma spp,trypanosomiasis,HUMAN AFRICAN TRYPANOSOMIASIS,IMMUNE-RESPONSE,MICE,RHODESIENSE},
  language     = {eng},
  number       = {10},
  pages        = {642--647},
  title        = {Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection},
  url          = {http://dx.doi.org/10.1111/pim.12344},
  volume       = {38},
  year         = {2016},
}

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