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Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection

(2016) PARASITE IMMUNOLOGY. 38(10). p.642-647
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Abstract
African trypanosomosis is a debilitating parasitic disease occurring in large parts of sub-Saharan Africa. Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing disease. Multiple experimental murine models for trypanosomosis have demonstrated inflammation-dependent apoptosis of splenic follicular B (FoB) cells and the destruction of B-cell memory against previously encountered pathogens. Here, we report that during murine infection with a chronic T.b.gambiense field isolate, FoB cells are retained. This coincided with reduced levels of IFN- and TNF- during the acute phase of the infection. This result suggests that in chronic infections with low virulent parasites, less inflammation is elicited and consequently no FoB cell destruction occurs.
Keywords
B lymphocyte, inflammation, Trypanosoma spp, trypanosomiasis, HUMAN AFRICAN TRYPANOSOMIASIS, IMMUNE-RESPONSE, MICE, RHODESIENSE

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MLA
Cnops, J et al. “Maintenance of B Cells During Chronic Murine Trypanosoma Brucei Gambiense Infection.” PARASITE IMMUNOLOGY 38.10 (2016): 642–647. Print.
APA
Cnops, J, Kauffmann, F., De Trez, C., Baltz, T., Keirsse, J., Radwanska, M., Muraille, E., et al. (2016). Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection. PARASITE IMMUNOLOGY, 38(10), 642–647.
Chicago author-date
Cnops, J, F Kauffmann, C De Trez, T Baltz, J Keirsse, Magdalena Radwanska, E Muraille, and Stefan Magez. 2016. “Maintenance of B Cells During Chronic Murine Trypanosoma Brucei Gambiense Infection.” Parasite Immunology 38 (10): 642–647.
Chicago author-date (all authors)
Cnops, J, F Kauffmann, C De Trez, T Baltz, J Keirsse, Magdalena Radwanska, E Muraille, and Stefan Magez. 2016. “Maintenance of B Cells During Chronic Murine Trypanosoma Brucei Gambiense Infection.” Parasite Immunology 38 (10): 642–647.
Vancouver
1.
Cnops J, Kauffmann F, De Trez C, Baltz T, Keirsse J, Radwanska M, et al. Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection. PARASITE IMMUNOLOGY. 2016;38(10):642–7.
IEEE
[1]
J. Cnops et al., “Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection,” PARASITE IMMUNOLOGY, vol. 38, no. 10, pp. 642–647, 2016.
@article{8528055,
  abstract     = {African trypanosomosis is a debilitating parasitic disease occurring in large parts of sub-Saharan Africa. Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing disease. Multiple experimental murine models for trypanosomosis have demonstrated inflammation-dependent apoptosis of splenic follicular B (FoB) cells and the destruction of B-cell memory against previously encountered pathogens. Here, we report that during murine infection with a chronic T.b.gambiense field isolate, FoB cells are retained. This coincided with reduced levels of IFN- and TNF- during the acute phase of the infection. This result suggests that in chronic infections with low virulent parasites, less inflammation is elicited and consequently no FoB cell destruction occurs.},
  author       = {Cnops, J and Kauffmann, F and De Trez, C and Baltz, T and Keirsse, J and Radwanska, Magdalena and Muraille, E and Magez, Stefan},
  issn         = {0141-9838},
  journal      = {PARASITE IMMUNOLOGY},
  keywords     = {B lymphocyte,inflammation,Trypanosoma spp,trypanosomiasis,HUMAN AFRICAN TRYPANOSOMIASIS,IMMUNE-RESPONSE,MICE,RHODESIENSE},
  language     = {eng},
  number       = {10},
  pages        = {642--647},
  title        = {Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection},
  url          = {http://dx.doi.org/10.1111/pim.12344},
  volume       = {38},
  year         = {2016},
}

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