Elemental and isotopic analysis of oral squamous cell carcinoma tissues using sector-field and multi-collector ICP-mass spectrometry
- Author
- Lara Lobo, Marta Costas Rodriguez (UGent) , Juan Carlos de Vicente, Rosario Pereiro, Frank Vanhaecke (UGent) and Alfredo Sanz-Medel
- Organization
- Abstract
- Elemental and isotopic analysis via single-collector and multi-collector ICP-mass spectrometry, respectively, have been explored as a tool for identifying potential differences between non-tumor and oral squamous cell carcinoma tissues. Elemental concentrations of major and minor elements, known to be essential for different processes in the cell (i.e. Na, Ca, Mg, K, P, Fe, Cu and Zn), have been determined and results for cancerous and non-cancerous tissues collected from the same individual have been compared. Among the elements studied, only Mg, K and P turned out to be significantly higher in concentration in the tumor tissues. However, a shift towards higher and wider concentration ranges has also been observed for Cu and Zn in the tumor samples, whereas for Ca lower concentrations were established. Possible isotope ratio variations for Cu and Zn in both biological tissues have also been evaluated with the same goal. delta Zn-66 results did not provide an obvious trend, but in the case of Cu, a clear distinction between the tumor and non-tumor tissues was observed: delta Cu-65 values ranged between -0.68% and 0.03% in the non-tumor tissues, whereas tumor samples turned out to be enriched in Cu-65, with delta Cu-65 values between 0.10% and 0.93%. These results confirm the considerable potential of isotopic and elemental studies for biomedical purposes.
- Keywords
- Sector-field ICP-MS, Multi-collector ICP-MS, Oral squamous cell carcinoma, Elemental determinations, Isotopic analysis, TRACE-ELEMENTS, MATRIX METALLOPROTEINASES, HEALTHY TISSUES, SERUM SAMPLES, TONGUE CANCER, BLOOD, COPPER, NICKEL, RATIO, PRODUCTS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8528038
- MLA
- Lobo, Lara, et al. “Elemental and Isotopic Analysis of Oral Squamous Cell Carcinoma Tissues Using Sector-Field and Multi-Collector ICP-Mass Spectrometry.” TALANTA, vol. 165, 2017, pp. 92–97, doi:10.1016/j.talanta.2016.12.007.
- APA
- Lobo, L., Costas Rodriguez, M., de Vicente, J. C., Pereiro, R., Vanhaecke, F., & Sanz-Medel, A. (2017). Elemental and isotopic analysis of oral squamous cell carcinoma tissues using sector-field and multi-collector ICP-mass spectrometry. TALANTA, 165, 92–97. https://doi.org/10.1016/j.talanta.2016.12.007
- Chicago author-date
- Lobo, Lara, Marta Costas Rodriguez, Juan Carlos de Vicente, Rosario Pereiro, Frank Vanhaecke, and Alfredo Sanz-Medel. 2017. “Elemental and Isotopic Analysis of Oral Squamous Cell Carcinoma Tissues Using Sector-Field and Multi-Collector ICP-Mass Spectrometry.” TALANTA 165: 92–97. https://doi.org/10.1016/j.talanta.2016.12.007.
- Chicago author-date (all authors)
- Lobo, Lara, Marta Costas Rodriguez, Juan Carlos de Vicente, Rosario Pereiro, Frank Vanhaecke, and Alfredo Sanz-Medel. 2017. “Elemental and Isotopic Analysis of Oral Squamous Cell Carcinoma Tissues Using Sector-Field and Multi-Collector ICP-Mass Spectrometry.” TALANTA 165: 92–97. doi:10.1016/j.talanta.2016.12.007.
- Vancouver
- 1.Lobo L, Costas Rodriguez M, de Vicente JC, Pereiro R, Vanhaecke F, Sanz-Medel A. Elemental and isotopic analysis of oral squamous cell carcinoma tissues using sector-field and multi-collector ICP-mass spectrometry. TALANTA. 2017;165:92–7.
- IEEE
- [1]L. Lobo, M. Costas Rodriguez, J. C. de Vicente, R. Pereiro, F. Vanhaecke, and A. Sanz-Medel, “Elemental and isotopic analysis of oral squamous cell carcinoma tissues using sector-field and multi-collector ICP-mass spectrometry,” TALANTA, vol. 165, pp. 92–97, 2017.
@article{8528038,
abstract = {{Elemental and isotopic analysis via single-collector and multi-collector ICP-mass spectrometry, respectively, have been explored as a tool for identifying potential differences between non-tumor and oral squamous cell carcinoma tissues. Elemental concentrations of major and minor elements, known to be essential for different processes in the cell (i.e. Na, Ca, Mg, K, P, Fe, Cu and Zn), have been determined and results for cancerous and non-cancerous tissues collected from the same individual have been compared. Among the elements studied, only Mg, K and P turned out to be significantly higher in concentration in the tumor tissues. However, a shift towards higher and wider concentration ranges has also been observed for Cu and Zn in the tumor samples, whereas for Ca lower concentrations were established. Possible isotope ratio variations for Cu and Zn in both biological tissues have also been evaluated with the same goal. delta Zn-66 results did not provide an obvious trend, but in the case of Cu, a clear distinction between the tumor and non-tumor tissues was observed: delta Cu-65 values ranged between -0.68% and 0.03% in the non-tumor tissues, whereas tumor samples turned out to be enriched in Cu-65, with delta Cu-65 values between 0.10% and 0.93%. These results confirm the considerable potential of isotopic and elemental studies for biomedical purposes.}},
author = {{Lobo, Lara and Costas Rodriguez, Marta and de Vicente, Juan Carlos and Pereiro, Rosario and Vanhaecke, Frank and Sanz-Medel, Alfredo}},
issn = {{0039-9140}},
journal = {{TALANTA}},
keywords = {{Sector-field ICP-MS,Multi-collector ICP-MS,Oral squamous cell carcinoma,Elemental determinations,Isotopic analysis,TRACE-ELEMENTS,MATRIX METALLOPROTEINASES,HEALTHY TISSUES,SERUM SAMPLES,TONGUE CANCER,BLOOD,COPPER,NICKEL,RATIO,PRODUCTS}},
language = {{eng}},
pages = {{92--97}},
title = {{Elemental and isotopic analysis of oral squamous cell carcinoma tissues using sector-field and multi-collector ICP-mass spectrometry}},
url = {{http://doi.org/10.1016/j.talanta.2016.12.007}},
volume = {{165}},
year = {{2017}},
}
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