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Osmolytes as mediators of the muscle tissue’s responses to inflammation : emerging regulators of myositis with therapeutic potential

Boel De Paepe (UGent)
(2017) EUROPEAN MEDICAL JOURNAL. RHEUMATOLOGY. 4(1). p.83-89
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Abstract
Chronic inflammation of skeletal muscle tissues termed myositis is associated with inherited muscular dystrophy and with acquired inflammatory myopathy. In this review, the role of the organic osmolytes taurine, betaine, myo-inositol and sorbitol in skeletal muscle in general and in myositis in particular, is discussed. Evidence indicates that regulated osmolyte pathway activation contributes to normal muscle functioning, which becomes further activated in myositis as part of the tissue’s program of damage control. On the one hand, osmolytes seem to act as protein stabilizers in muscle fibers counteracting tissue injury but, on the other hand, these compounds also regulate immune cell function. The possibilities for treating myositis through boosting of beneficial or targeting of adversary effects are explored.
Keywords
betaine, dermatomyositis, immune-mediated necrotizing myopathy, inflammatory myopathy, muscular dystrophy, myo-inositol, osmolytes, polymyositis, sorbitol, sporadic inclusion body myositis, taurine

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Citation

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MLA
De Paepe, Boel. “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation : Emerging Regulators of Myositis with Therapeutic Potential.” EUROPEAN MEDICAL JOURNAL. RHEUMATOLOGY, vol. 4, no. 1, 2017, pp. 83–89.
APA
De Paepe, B. (2017). Osmolytes as mediators of the muscle tissue’s responses to inflammation : emerging regulators of myositis with therapeutic potential. EUROPEAN MEDICAL JOURNAL. RHEUMATOLOGY, 4(1), 83–89.
Chicago author-date
De Paepe, Boel. 2017. “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation : Emerging Regulators of Myositis with Therapeutic Potential.” EUROPEAN MEDICAL JOURNAL. RHEUMATOLOGY 4 (1): 83–89.
Chicago author-date (all authors)
De Paepe, Boel. 2017. “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation : Emerging Regulators of Myositis with Therapeutic Potential.” EUROPEAN MEDICAL JOURNAL. RHEUMATOLOGY 4 (1): 83–89.
Vancouver
1.
De Paepe B. Osmolytes as mediators of the muscle tissue’s responses to inflammation : emerging regulators of myositis with therapeutic potential. EUROPEAN MEDICAL JOURNAL RHEUMATOLOGY. 2017;4(1):83–9.
IEEE
[1]
B. De Paepe, “Osmolytes as mediators of the muscle tissue’s responses to inflammation : emerging regulators of myositis with therapeutic potential,” EUROPEAN MEDICAL JOURNAL. RHEUMATOLOGY, vol. 4, no. 1, pp. 83–89, 2017.
@article{8528001,
  abstract     = {{Chronic inflammation of skeletal muscle tissues termed myositis is associated with inherited muscular dystrophy and with acquired inflammatory myopathy. In this review, the role of the organic osmolytes taurine, betaine, myo-inositol and sorbitol in skeletal muscle in general and in myositis in particular, is discussed. Evidence indicates that regulated osmolyte pathway activation contributes to normal muscle functioning, which becomes further activated in myositis as part of the tissue’s program of damage control. On the one hand, osmolytes seem to act as protein stabilizers in muscle fibers counteracting tissue injury but, on the other hand, these compounds also regulate immune cell function. The possibilities for treating myositis through boosting of beneficial or targeting of adversary effects are explored.}},
  author       = {{De Paepe, Boel}},
  issn         = {{2056-6395}},
  journal      = {{EUROPEAN MEDICAL JOURNAL. RHEUMATOLOGY}},
  keywords     = {{betaine,dermatomyositis,immune-mediated necrotizing myopathy,inflammatory myopathy,muscular dystrophy,myo-inositol,osmolytes,polymyositis,sorbitol,sporadic inclusion body myositis,taurine}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{83--89}},
  title        = {{Osmolytes as mediators of the muscle tissue’s responses to inflammation : emerging regulators of myositis with therapeutic potential}},
  url          = {{http://emjreviews.com/therapeutic-area/rheumatology/osmolytes-as-mediators-of-the-muscle-tissues-responses-to-inflammation-emerging-regulators-of-myositis-with-therapeutic-potential/}},
  volume       = {{4}},
  year         = {{2017}},
}