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Tumour tissue transport after intraperitoneal anticancer drug delivery

Charlotte Carlier (UGent) , Ada Mathys, Emiel De Jaeghere (UGent) , Margo Steuperaert (UGent) , Olivier De Wever (UGent) and Wim Ceelen (UGent)
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Abstract
Intraperitoneal (IP) drug delivery, either as an intraoperative chemoperfusion or as an adjuvant, repeated instillation, is an established treatment modality in patients with peritoneal carcinomatosis. The efficacy of IP drugs depends on its ability to penetrate the tumour stroma in order to reach their (sub)cellular target. It is known, that drug penetration after IP delivery is limited to a few millimetres. Here, we review the basic tissue transport mechanisms after IP delivery and discuss the biophysical barriers and obstacles that limit penetration distance. In addition, we review the physical and pharmaceutical interventions that have been studied in order to improve delivery of small molecular and macromolecular drugs after IP instillation. These interventions could inform the design of future clinical trials aiming at an improved efficacy of IP-based drug delivery in carcinomatosis patients.
Keywords
Intraperitoneal, carcinomatosis, drug delivery, pharmacokinetics, INTERSTITIAL FLUID PRESSURE, INTENSITY FOCUSED ULTRASOUND, AEROSOL CHEMOTHERAPY PIPAC, PANCREATIC DUCTAL ADENOCARCINOMA, HUMAN OSTEOSARCOMA XENOGRAFTS, HEDGEHOG PATHWAY INHIBITOR, PERITONEAL CARCINOMATOSIS, OVARIAN-CANCER, IN-VIVO, SOLID TUMORS

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Chicago
Carlier, Charlotte, Ada Mathys, Emiel De Jaeghere, Margo Steuperaert, Olivier De Wever, and Wim Ceelen. 2017. “Tumour Tissue Transport After Intraperitoneal Anticancer Drug Delivery.” International Journal of Hyperthermia 33 (5): 534–542.
APA
Carlier, C., Mathys, A., De Jaeghere, E., Steuperaert, M., De Wever, O., & Ceelen, W. (2017). Tumour tissue transport after intraperitoneal anticancer drug delivery. INTERNATIONAL JOURNAL OF HYPERTHERMIA, 33(5), 534–542.
Vancouver
1.
Carlier C, Mathys A, De Jaeghere E, Steuperaert M, De Wever O, Ceelen W. Tumour tissue transport after intraperitoneal anticancer drug delivery. INTERNATIONAL JOURNAL OF HYPERTHERMIA. 2017;33(5):534–42.
MLA
Carlier, Charlotte, Ada Mathys, Emiel De Jaeghere, et al. “Tumour Tissue Transport After Intraperitoneal Anticancer Drug Delivery.” INTERNATIONAL JOURNAL OF HYPERTHERMIA 33.5 (2017): 534–542. Print.
@article{8527982,
  abstract     = {Intraperitoneal (IP) drug delivery, either as an intraoperative chemoperfusion or as an adjuvant, repeated instillation, is an established treatment modality in patients with peritoneal carcinomatosis. The efficacy of IP drugs depends on its ability to penetrate the tumour stroma in order to reach their (sub)cellular target. It is known, that drug penetration after IP delivery is limited to a few millimetres. Here, we review the basic tissue transport mechanisms after IP delivery and discuss the biophysical barriers and obstacles that limit penetration distance. In addition, we review the physical and pharmaceutical interventions that have been studied in order to improve delivery of small molecular and macromolecular drugs after IP instillation. These interventions could inform the design of future clinical trials aiming at an improved efficacy of IP-based drug delivery in carcinomatosis patients.},
  author       = {Carlier, Charlotte and Mathys, Ada and De Jaeghere, Emiel and Steuperaert, Margo and De Wever, Olivier and Ceelen, Wim},
  issn         = {0265-6736},
  journal      = {INTERNATIONAL JOURNAL OF HYPERTHERMIA},
  keyword      = {Intraperitoneal,carcinomatosis,drug delivery,pharmacokinetics,INTERSTITIAL FLUID PRESSURE,INTENSITY FOCUSED ULTRASOUND,AEROSOL CHEMOTHERAPY PIPAC,PANCREATIC DUCTAL ADENOCARCINOMA,HUMAN OSTEOSARCOMA XENOGRAFTS,HEDGEHOG PATHWAY INHIBITOR,PERITONEAL CARCINOMATOSIS,OVARIAN-CANCER,IN-VIVO,SOLID TUMORS},
  language     = {eng},
  number       = {5},
  pages        = {534--542},
  title        = {Tumour tissue transport after intraperitoneal anticancer drug delivery},
  url          = {http://dx.doi.org/10.1080/02656736.2017.1312563},
  volume       = {33},
  year         = {2017},
}

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