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Stability of bacteriophages in burn wound care products

Maia Merabishvili UGent, Riet Monserez, Jonas Van Belleghem UGent, Thomas Rose, Serge Jennes, Daniel De Vos, Gilbert Verbeken, Mario Vaneechoutte UGent and Jean-Paul Pirnay (2017) PLOS ONE. 12(7).
abstract
Bacteriophages could be used along with burn wound care products to enhance antimicrobial pressure during treatment. However, some of the components of the topical antimicrobials that are traditionally used for the prevention and treatment of burn wound infection might affect the activity of phages. Therefore, it is imperative to determine the counteraction of therapeutic phage preparations by burn wound care products before application in patients. Five phages, representatives of two morphological families (Myoviridae and Podoviridae) and active against 3 common bacterial burn wound pathogens (Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus) were tested against 13 different products commonly used in the treatment of burn wounds. The inactivation of the phages was quite variable for different phages and different products. Majority of the anti-infective products affected phage activity negatively either immediately or in the course of time, although impact was not always significant. Products with high acidity had the most adverse effect on phages. Our findings demonstrate that during combined treatment the choice of phages and wound care products must be carefully defined in advance.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PSEUDOMONAS-AERUGINOSA, ANTIBACTERIAL ACTIVITY, INFECTIONS, MUPIROCIN, COLONIZATION, 21ST-CENTURY, EPIDEMIOLOGY, MECHANISM
journal title
PLOS ONE
PLoS One
volume
12
issue
7
article number
0182121
pages
15 pages
Web of Science type
Article
Web of Science id
000406575700137
ISSN
1932-6203
DOI
10.1371/journal.pone.0182121
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
8527856
handle
http://hdl.handle.net/1854/LU-8527856
date created
2017-07-31 09:51:07
date last changed
2017-10-05 11:46:56
@article{8527856,
  abstract     = {Bacteriophages could be used along with burn wound care products to enhance antimicrobial pressure during treatment. However, some of the components of the topical antimicrobials that are traditionally used for the prevention and treatment of burn wound infection might affect the activity of phages. Therefore, it is imperative to determine the counteraction of therapeutic phage preparations by burn wound care products before application in patients. Five phages, representatives of two morphological families (Myoviridae and Podoviridae) and active against 3 common bacterial burn wound pathogens (Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus) were tested against 13 different products commonly used in the treatment of burn wounds. The inactivation of the phages was quite variable for different phages and different products. Majority of the anti-infective products affected phage activity negatively either immediately or in the course of time, although impact was not always significant. Products with high acidity had the most adverse effect on phages. Our findings demonstrate that during combined treatment the choice of phages and wound care products must be carefully defined in advance.},
  articleno    = {0182121},
  author       = {Merabishvili, Maia and Monserez, Riet and Van Belleghem, Jonas and Rose, Thomas and Jennes, Serge and De Vos, Daniel and Verbeken, Gilbert and Vaneechoutte, Mario and Pirnay, Jean-Paul},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {PSEUDOMONAS-AERUGINOSA,ANTIBACTERIAL ACTIVITY,INFECTIONS,MUPIROCIN,COLONIZATION,21ST-CENTURY,EPIDEMIOLOGY,MECHANISM},
  language     = {eng},
  number       = {7},
  pages        = {15},
  title        = {Stability of bacteriophages in burn wound care products},
  url          = {http://dx.doi.org/10.1371/journal.pone.0182121},
  volume       = {12},
  year         = {2017},
}

Chicago
Merabishvili, Maia, Riet Monserez, Jonas Van Belleghem, Thomas Rose, Serge Jennes, Daniel De Vos, Gilbert Verbeken, Mario Vaneechoutte, and Jean-Paul Pirnay. 2017. “Stability of Bacteriophages in Burn Wound Care Products.” Plos One 12 (7).
APA
Merabishvili, Maia, Monserez, R., Van Belleghem, J., Rose, T., Jennes, S., De Vos, D., Verbeken, G., et al. (2017). Stability of bacteriophages in burn wound care products. PLOS ONE, 12(7).
Vancouver
1.
Merabishvili M, Monserez R, Van Belleghem J, Rose T, Jennes S, De Vos D, et al. Stability of bacteriophages in burn wound care products. PLOS ONE. 2017;12(7).
MLA
Merabishvili, Maia, Riet Monserez, Jonas Van Belleghem, et al. “Stability of Bacteriophages in Burn Wound Care Products.” PLOS ONE 12.7 (2017): n. pag. Print.