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Stability of bacteriophages in burn wound care products

(2017) PLOS ONE. 12(7).
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Abstract
Bacteriophages could be used along with burn wound care products to enhance antimicrobial pressure during treatment. However, some of the components of the topical antimicrobials that are traditionally used for the prevention and treatment of burn wound infection might affect the activity of phages. Therefore, it is imperative to determine the counteraction of therapeutic phage preparations by burn wound care products before application in patients. Five phages, representatives of two morphological families (Myoviridae and Podoviridae) and active against 3 common bacterial burn wound pathogens (Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus) were tested against 13 different products commonly used in the treatment of burn wounds. The inactivation of the phages was quite variable for different phages and different products. Majority of the anti-infective products affected phage activity negatively either immediately or in the course of time, although impact was not always significant. Products with high acidity had the most adverse effect on phages. Our findings demonstrate that during combined treatment the choice of phages and wound care products must be carefully defined in advance.
Keywords
PSEUDOMONAS-AERUGINOSA, ANTIBACTERIAL ACTIVITY, INFECTIONS, MUPIROCIN, COLONIZATION, 21ST-CENTURY, EPIDEMIOLOGY, MECHANISM

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Chicago
Merabishvili, Maia, Riet Monserez, Jonas Van Belleghem, Thomas Rose, Serge Jennes, Daniel De Vos, Gilbert Verbeken, Mario Vaneechoutte, and Jean-Paul Pirnay. 2017. “Stability of Bacteriophages in Burn Wound Care Products.” Plos One 12 (7).
APA
Merabishvili, Maia, Monserez, R., Van Belleghem, J., Rose, T., Jennes, S., De Vos, D., Verbeken, G., et al. (2017). Stability of bacteriophages in burn wound care products. PLOS ONE, 12(7).
Vancouver
1.
Merabishvili M, Monserez R, Van Belleghem J, Rose T, Jennes S, De Vos D, et al. Stability of bacteriophages in burn wound care products. PLOS ONE. 2017;12(7).
MLA
Merabishvili, Maia, Riet Monserez, Jonas Van Belleghem, et al. “Stability of Bacteriophages in Burn Wound Care Products.” PLOS ONE 12.7 (2017): n. pag. Print.
@article{8527856,
  abstract     = {Bacteriophages could be used along with burn wound care products to enhance antimicrobial pressure during treatment. However, some of the components of the topical antimicrobials that are traditionally used for the prevention and treatment of burn wound infection might affect the activity of phages. Therefore, it is imperative to determine the counteraction of therapeutic phage preparations by burn wound care products before application in patients. Five phages, representatives of two morphological families (Myoviridae and Podoviridae) and active against 3 common bacterial burn wound pathogens (Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus) were tested against 13 different products commonly used in the treatment of burn wounds. The inactivation of the phages was quite variable for different phages and different products. Majority of the anti-infective products affected phage activity negatively either immediately or in the course of time, although impact was not always significant. Products with high acidity had the most adverse effect on phages. Our findings demonstrate that during combined treatment the choice of phages and wound care products must be carefully defined in advance.},
  articleno    = {0182121},
  author       = {Merabishvili, Maia and Monserez, Riet and Van Belleghem, Jonas and Rose, Thomas and Jennes, Serge and De Vos, Daniel and Verbeken, Gilbert and Vaneechoutte, Mario and Pirnay, Jean-Paul},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {PSEUDOMONAS-AERUGINOSA,ANTIBACTERIAL ACTIVITY,INFECTIONS,MUPIROCIN,COLONIZATION,21ST-CENTURY,EPIDEMIOLOGY,MECHANISM},
  language     = {eng},
  number       = {7},
  pages        = {15},
  title        = {Stability of bacteriophages in burn wound care products},
  url          = {http://dx.doi.org/10.1371/journal.pone.0182121},
  volume       = {12},
  year         = {2017},
}

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