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Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin

Julie Deckers UGent, Karolien De Bosscher UGent, Bart Lambrecht UGent and Hamida Hammad UGent (2017) IMMUNOLOGICAL REVIEWS. 278(1). p.131-144
abstract
The prevalence of asthma is increasing over the years and it has become obvious that a thorough understanding of mechanisms leading to Th2 sensitization and to asthma is urgently needed to provide better ways to treat the disease. This articles reviews the different players involved in the initiation of allergic reactions in the lung and in the skin, and highlights the importance of a crosstalk between antigen-presenting dendritic cells and structural cell-derived signals in this process. Our increasing understanding of these mechanisms indicates that structural cells, such as airway epithelial cells and skin keratinocytes, need to be considered as more than a simple physical barrier since they are very upstream of the entire Th2 cascade and therefore might represent crucial targets for new therapies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
THYMIC STROMAL LYMPHOPOIETIN, HOUSE-DUST MITE, INNATE LYMPHOID-CELLS, CD4(+) T-CELLS, EOSINOPHILIC AIRWAY INFLAMMATION, PROTEASE-ACTIVATED, RECEPTOR-2, RESPIRATORY SYNCYTIAL VIRUS, ATOPIC-DERMATITIS, LANGERHANS, CELLS, HUMAN KERATINOCYTES, asthma, dendritic cells, inflammation, lung, skin
journal title
IMMUNOLOGICAL REVIEWS
Immunol. Rev.
volume
278
issue
1
pages
14 pages
publisher
Wiley
place of publication
Hoboken
Web of Science type
Review
Web of Science id
000404254300009
ISSN
0105-2896
DOI
10.1111/imr.12542
language
English
UGent publication?
yes
classification
U
id
8527502
handle
http://hdl.handle.net/1854/LU-8527502
date created
2017-07-24 12:31:02
date last changed
2017-07-24 12:31:02
@article{8527502,
  abstract     = {The prevalence of asthma is increasing over the years and it has become obvious that a thorough understanding of mechanisms leading to Th2 sensitization and to asthma is urgently needed to provide better ways to treat the disease. This articles reviews the different players involved in the initiation of allergic reactions in the lung and in the skin, and highlights the importance of a crosstalk between antigen-presenting dendritic cells and structural cell-derived signals in this process. Our increasing understanding of these mechanisms indicates that structural cells, such as airway epithelial cells and skin keratinocytes, need to be considered as more than a simple physical barrier since they are very upstream of the entire Th2 cascade and therefore might represent crucial targets for new therapies.},
  author       = {Deckers, Julie and De Bosscher, Karolien and Lambrecht, Bart and Hammad, Hamida},
  issn         = {0105-2896},
  journal      = {IMMUNOLOGICAL REVIEWS},
  keyword      = {THYMIC STROMAL LYMPHOPOIETIN,HOUSE-DUST MITE,INNATE LYMPHOID-CELLS,CD4(+) T-CELLS,EOSINOPHILIC AIRWAY INFLAMMATION,PROTEASE-ACTIVATED,RECEPTOR-2,RESPIRATORY SYNCYTIAL VIRUS,ATOPIC-DERMATITIS,LANGERHANS,CELLS,HUMAN KERATINOCYTES,asthma,dendritic cells,inflammation,lung,skin},
  language     = {eng},
  number       = {1},
  pages        = {131--144},
  publisher    = {Wiley},
  title        = {Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin},
  url          = {http://dx.doi.org/10.1111/imr.12542},
  volume       = {278},
  year         = {2017},
}

Chicago
Deckers, Julie, Karolien De Bosscher, Bart Lambrecht, and Hamida Hammad. 2017. “Interplay Between Barrier Epithelial Cells and Dendritic Cells in Allergic Sensitization Through the Lung and the Skin.” Immunological Reviews 278 (1): 131–144.
APA
Deckers, J., De Bosscher, K., Lambrecht, B., & Hammad, H. (2017). Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin. IMMUNOLOGICAL REVIEWS, 278(1), 131–144.
Vancouver
1.
Deckers J, De Bosscher K, Lambrecht B, Hammad H. Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin. IMMUNOLOGICAL REVIEWS. Hoboken: Wiley; 2017;278(1):131–44.
MLA
Deckers, Julie, Karolien De Bosscher, Bart Lambrecht, et al. “Interplay Between Barrier Epithelial Cells and Dendritic Cells in Allergic Sensitization Through the Lung and the Skin.” IMMUNOLOGICAL REVIEWS 278.1 (2017): 131–144. Print.