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The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1

(2016) ALLERGY. 71(10). p.1490-1495
Author
Organization
Abstract
We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.
Keywords
Can f 1, cat allergy, cross-reactivity, dog allergy, Fel d 7, T-CELL RECOGNITION, CRYSTAL-STRUCTURE, FURRY ANIMALS, ALLERGENS, SENSITIZATION, PATTERNS, INSIGHTS, IGE

Citation

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MLA
Apostolovic, D et al. “The Cat Lipocalin Fel d 7 and Its Cross-reactivity with the Dog Lipocalin Can f 1.” ALLERGY 71.10 (2016): 1490–1495. Print.
APA
Apostolovic, D, Sánchez-Vidaurre, S., Waden, K., Curin, M., Grundström, J., Gafvelin, G., Cirkovic Velickovic, T., et al. (2016). The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. ALLERGY, 71(10), 1490–1495.
Chicago author-date
Apostolovic, D, S Sánchez-Vidaurre, K Waden, M Curin, J Grundström, G Gafvelin, Tanja Cirkovic Velickovic, et al. 2016. “The Cat Lipocalin Fel d 7 and Its Cross-reactivity with the Dog Lipocalin Can f 1.” Allergy 71 (10): 1490–1495.
Chicago author-date (all authors)
Apostolovic, D, S Sánchez-Vidaurre, K Waden, M Curin, J Grundström, G Gafvelin, Tanja Cirkovic Velickovic, H Grönlund, WR Thomas, R Valenta, C Hamsten, and M van Hage. 2016. “The Cat Lipocalin Fel d 7 and Its Cross-reactivity with the Dog Lipocalin Can f 1.” Allergy 71 (10): 1490–1495.
Vancouver
1.
Apostolovic D, Sánchez-Vidaurre S, Waden K, Curin M, Grundström J, Gafvelin G, et al. The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. ALLERGY. 2016;71(10):1490–5.
IEEE
[1]
D. Apostolovic et al., “The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1,” ALLERGY, vol. 71, no. 10, pp. 1490–1495, 2016.
@article{8527353,
  abstract     = {We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.},
  author       = {Apostolovic, D and Sánchez-Vidaurre, S and Waden, K and Curin, M and Grundström, J and Gafvelin, G and Cirkovic Velickovic, Tanja and Grönlund, H and Thomas, WR and Valenta, R and Hamsten, C and van Hage, M},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keywords     = {Can f 1,cat allergy,cross-reactivity,dog allergy,Fel d 7,T-CELL RECOGNITION,CRYSTAL-STRUCTURE,FURRY ANIMALS,ALLERGENS,SENSITIZATION,PATTERNS,INSIGHTS,IGE},
  language     = {eng},
  number       = {10},
  pages        = {1490--1495},
  title        = {The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1},
  url          = {http://dx.doi.org/10.1111/all.12955},
  volume       = {71},
  year         = {2016},
}

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