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Serum C-reactive protein concentrations in dogs with idiopathic epilepsy

Eline Segers, Valentine Martlé (UGent) , Sofie Piepers (UGent) , Luc Van Ham (UGent) and Sofie Bhatti (UGent)
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Abstract
Inflammatory reactions in dogs are associated with systemic changes in serum, called the acute phase response; changes in the concentration of acute phase proteins in the serum take place. C-reactive protein (CRP) is a positive acute phase protein, which increases during inflammation. The role of inflammation in epilepsy remains unclear. In this study, the inflammatory response in dogs with idiopathic epilepsy (1E) was investigated. The aims of the study were: 1. to measure serum CRP concentrations in dogs with IE and in healthy dogs, 2. to measure serum CRP concentrations in dogs with acute cluster seizures and in dogs with isolated seizures and 3. to observe the evolution of serum CRP concentrations in time after the last seizure. This study showed no significant differences in serum CRP concentrations between dogs with IE (7.8 mg/I) and dogs of the control group (8.3 mg/I). Furthermore, the results showed higher mean serum CRP concentrations in dogs with IE exhibiting cluster seizures (11,8 mg/I) than in dogs with isolated seizures (5.7 mg/I). However, these results were not statistically significant (P = 0,077). Finally, no statistically significant decrease in serum CRP concentrations was seen with time after the last epileptic seizure in dogs with IE (P = 0,077).
Keywords
CEREBROSPINAL-FLUID, SEIZURES, INTERLEUKIN-6, INFLAMMATION, EPILEPTICUS, PENTRAXINS

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Citation

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Chicago
Segers, Eline, Valentine Martlé, Sofie Piepers, Luc Van Ham, and Sofie Bhatti. 2017. “Serum C-reactive Protein Concentrations in Dogs with Idiopathic Epilepsy.” Vlaams Diergeneeskundig Tijdschrift 86 (2): 79–83.
APA
Segers, E., Martlé, V., Piepers, S., Van Ham, L., & Bhatti, S. (2017). Serum C-reactive protein concentrations in dogs with idiopathic epilepsy. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 86(2), 79–83.
Vancouver
1.
Segers E, Martlé V, Piepers S, Van Ham L, Bhatti S. Serum C-reactive protein concentrations in dogs with idiopathic epilepsy. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2017;86(2):79–83.
MLA
Segers, Eline et al. “Serum C-reactive Protein Concentrations in Dogs with Idiopathic Epilepsy.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 86.2 (2017): 79–83. Print.
@article{8527022,
  abstract     = {Inflammatory reactions in dogs are associated with systemic changes in serum, called the acute phase response; changes in the concentration of acute phase proteins in the serum take place. C-reactive protein (CRP) is a positive acute phase protein, which increases during inflammation. The role of inflammation in epilepsy remains unclear. In this study, the inflammatory response in dogs with idiopathic epilepsy (1E) was investigated. The aims of the study were: 1. to measure serum CRP concentrations in dogs with IE and in healthy dogs, 2. to measure serum CRP concentrations in dogs with acute cluster seizures and in dogs with isolated seizures and 3. to observe the evolution of serum CRP concentrations in time after the last seizure. This study showed no significant differences in serum CRP concentrations between dogs with IE (7.8 mg/I) and dogs of the control group (8.3 mg/I). Furthermore, the results showed higher mean serum CRP concentrations in dogs with IE exhibiting cluster seizures (11,8 mg/I) than in dogs with isolated seizures (5.7 mg/I). However, these results were not statistically significant (P = 0,077). Finally, no statistically significant decrease in serum CRP concentrations was seen with time after the last epileptic seizure in dogs with IE (P = 0,077).},
  author       = {Segers, Eline and Martlé, Valentine and Piepers, Sofie and Van Ham, Luc and Bhatti, Sofie},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  keywords     = {CEREBROSPINAL-FLUID,SEIZURES,INTERLEUKIN-6,INFLAMMATION,EPILEPTICUS,PENTRAXINS},
  language     = {eng},
  number       = {2},
  pages        = {79--83},
  title        = {Serum C-reactive protein concentrations in dogs with idiopathic epilepsy},
  volume       = {86},
  year         = {2017},
}

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