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The role of interleukin-17A in the pathogenesis of kidney diseases

(2017) PATHOLOGY. 49(3). p.247-258
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Abstract
Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a cytokine, produced by multiple cell types, such as CD4(+) ab T cells, gamma delta T cells, natural killer cells, neutrophils, macrophages, dendritic cells, lymphoid tissue inducer cells, mast cells and plasma cells. IL-17A participates in tissue inflammation by inducing the expression of chemokines, proinflammatory cytokines and matrix metalloproteases. Besides its role in host defence against infectious diseases, IL-17A is involved in different autoimmune and inflammatory diseases. In this review, we will highlight the role of IL-17A in the pathogenesis of acute and chronic kidney diseases. Due to its pleiotropic character, IL-17A is involved in the development of atherosclerosis, hypertension, diabetic nephropathy, ischaemia-reperfusion injury, fibrosis, glomerulonephritis, nephrotic syndrome, minimal change disease and acute renal allograft rejection. In addition, inhibition of IL-17A may be a promising therapeutic target to prevent end-stage renal disease.
Keywords
Interleukin-17A, inflammation, kidney disease, ISCHEMIA-REPERFUSION INJURY, T-HELPER 17, SYSTEMIC-LUPUS-ERYTHEMATOSUS, PRIMARY NEPHROTIC SYNDROME, RENAL-ALLOGRAFT REJECTION, HENOCH-SCHONLEIN PURPURA, II-INDUCED HYPERTENSION, E-DEFICIENT MICE, GAMMA-DELTA T, TH17 CELLS

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Citation

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Chicago
Cortvrindt, Charlotte, Reinhart Speeckaert, Alena Moerman, Joris Delanghe, and Marijn Speeckaert. 2017. “The Role of interleukin-17A in the Pathogenesis of Kidney Diseases.” Pathology 49 (3): 247–258.
APA
Cortvrindt, C., Speeckaert, R., Moerman, A., Delanghe, J., & Speeckaert, M. (2017). The role of interleukin-17A in the pathogenesis of kidney diseases. PATHOLOGY, 49(3), 247–258.
Vancouver
1.
Cortvrindt C, Speeckaert R, Moerman A, Delanghe J, Speeckaert M. The role of interleukin-17A in the pathogenesis of kidney diseases. PATHOLOGY. 2017;49(3):247–58.
MLA
Cortvrindt, Charlotte, Reinhart Speeckaert, Alena Moerman, et al. “The Role of interleukin-17A in the Pathogenesis of Kidney Diseases.” PATHOLOGY 49.3 (2017): 247–258. Print.
@article{8525660,
  abstract     = {Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a cytokine, produced by multiple cell types, such as CD4(+) ab T cells, gamma delta T cells, natural killer cells, neutrophils, macrophages, dendritic cells, lymphoid tissue inducer cells, mast cells and plasma cells. IL-17A participates in tissue inflammation by inducing the expression of chemokines, proinflammatory cytokines and matrix metalloproteases. Besides its role in host defence against infectious diseases, IL-17A is involved in different autoimmune and inflammatory diseases. In this review, we will highlight the role of IL-17A in the pathogenesis of acute and chronic kidney diseases. Due to its pleiotropic character, IL-17A is involved in the development of atherosclerosis, hypertension, diabetic nephropathy, ischaemia-reperfusion injury, fibrosis, glomerulonephritis, nephrotic syndrome, minimal change disease and acute renal allograft rejection. In addition, inhibition of IL-17A may be a promising therapeutic target to prevent end-stage renal disease.},
  author       = {Cortvrindt, Charlotte and Speeckaert, Reinhart and Moerman, Alena and Delanghe, Joris and Speeckaert, Marijn},
  issn         = {0031-3025},
  journal      = {PATHOLOGY},
  keyword      = {Interleukin-17A,inflammation,kidney disease,ISCHEMIA-REPERFUSION INJURY,T-HELPER 17,SYSTEMIC-LUPUS-ERYTHEMATOSUS,PRIMARY NEPHROTIC SYNDROME,RENAL-ALLOGRAFT REJECTION,HENOCH-SCHONLEIN PURPURA,II-INDUCED HYPERTENSION,E-DEFICIENT MICE,GAMMA-DELTA T,TH17 CELLS},
  language     = {eng},
  number       = {3},
  pages        = {247--258},
  title        = {The role of interleukin-17A in the pathogenesis of kidney diseases},
  url          = {http://dx.doi.org/10.1016/j.pathol.2017.01.003},
  volume       = {49},
  year         = {2017},
}

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