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A vertebrate-specific and essential role for osterix in osteogenesis revealed by gene knockout in the teleost medaka

(2017) DEVELOPMENT. 144(2). p.265-271
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Abstract
osterix (osx; sp7) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation remains elusive. Here, we show that an osx mutation in medaka results in severe bone defects and larval lethality. Pre-osteoblasts fail to differentiate leading to severe intramembranous and perichondral ossification defects. The notochord sheath mineralizes normally, supporting the idea of an osteoblast-independent mechanism for teleost vertebral centra formation. This study establishes a key role for Osx for bone formation in a non-mammalian species, and reveals conserved and non-conserved features in vertebrate bone formation.
Keywords
SALMON SALMO-SALAR, BONE-FORMATION, OSTEOBLAST DIFFERENTIATION, AXIAL, SKELETON, RETINOIC ACID, COMMON CARP, ZEBRAFISH, CELLS, MINERALIZATION, EVOLUTION, Osteoblasts, Osteogenesis, Bone modelling, Skeleton, Medaka

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Chicago
Yu, Tingsheng, Martin Graf, Joerg Renn, Manfred Schartl, Daria Larionova, Ann Huysseune, Paul Witten, and Christoph Winkler. 2017. “A Vertebrate-specific and Essential Role for Osterix in Osteogenesis Revealed by Gene Knockout in the Teleost Medaka.” Development 144 (2): 265–271.
APA
Yu, T., Graf, M., Renn, J., Schartl, M., Larionova, D., Huysseune, A., Witten, P., et al. (2017). A vertebrate-specific and essential role for osterix in osteogenesis revealed by gene knockout in the teleost medaka. DEVELOPMENT, 144(2), 265–271.
Vancouver
1.
Yu T, Graf M, Renn J, Schartl M, Larionova D, Huysseune A, et al. A vertebrate-specific and essential role for osterix in osteogenesis revealed by gene knockout in the teleost medaka. DEVELOPMENT. 2017;144(2):265–71.
MLA
Yu, Tingsheng et al. “A Vertebrate-specific and Essential Role for Osterix in Osteogenesis Revealed by Gene Knockout in the Teleost Medaka.” DEVELOPMENT 144.2 (2017): 265–271. Print.
@article{8525440,
  abstract     = {osterix (osx; sp7) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation remains elusive. Here, we show that an osx mutation in medaka results in severe bone defects and larval lethality. Pre-osteoblasts fail to differentiate leading to severe intramembranous and perichondral ossification defects. The notochord sheath mineralizes normally, supporting the idea of an osteoblast-independent mechanism for teleost vertebral centra formation. This study establishes a key role for Osx for bone formation in a non-mammalian species, and reveals conserved and non-conserved features in vertebrate bone formation.},
  author       = {Yu, Tingsheng and Graf, Martin and Renn, Joerg and Schartl, Manfred and Larionova, Daria and Huysseune, Ann and Witten, Paul and Winkler, Christoph},
  issn         = {0950-1991},
  journal      = {DEVELOPMENT},
  language     = {eng},
  number       = {2},
  pages        = {265--271},
  title        = {A vertebrate-specific and essential role for osterix in osteogenesis revealed by gene knockout in the teleost medaka},
  url          = {http://dx.doi.org/10.1242/dev.139550},
  volume       = {144},
  year         = {2017},
}

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