Advanced search
1 file | 953.74 KB

Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults : research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO)

(2017) ENDOCRINE. 56(2). p.245-261
Author
Organization
Abstract
Introduction: Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. Purpose and Methods: Members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis have reviewed the main evidence for possible proven benefits of vitamin D supplementation in adults at risk of or with overt chronic extra-skeletal diseases, providing recommendations and guidelines for future studies in this field. Results and conclusions: Robust mechanistic evidence is available from in vitro studies and in vivo animal studies, usually employing cholecalciferol, calcidiol or calcitriol in pharmacologic rather than physiologic doses. Although many cross-sectional and prospective association studies in humans have shown that low 25-hydroxyvitamin D levels (i.e., < 50 nmol/L) are consistently associated with chronic diseases, further strengthened by a dose-response relationship, several meta-analyses of clinical trials have shown contradictory results. Overall, large randomized controlled trials with sufficient doses of vitamin D are missing, and available small to moderate-size trials often included people with baseline levels of serum 25-hydroxyvitamin D levels > 50 nmol/L, did not simultaneously assess multiple outcomes, and did not report overall safety (e.g., falls). Thus, no recommendations can be made to date for the use of vitamin D supplementation in general, parental compounds, or non-hypercalcemic vitamin D analogs in the prevention and treatment of extra-skeletal chronic diseases. Moreover, attainment of serum 25-hydroxyvitamin D levels well above the threshold desired for bone health cannot be recommended based on current evidence, since safety has yet to be confirmed. Finally, the promising findings from mechanistic studies, large cohort studies, and small clinical trials obtained for autoimmune diseases (including type 1 diabetes, multiple sclerosis, and systemic lupus erythematosus), cardiovascular disorders, and overall reduction in mortality require further confirmation.
Keywords
Cholecalciferol, Cancer, Diabetes, Mortality, Cardiovascular diseases, Autoimmune diseases, RANDOMIZED CONTROLLED-TRIAL, SYSTEMIC-LUPUS-ERYTHEMATOSUS, SERUM 25-HYDROXYVITAMIN D, PLACEBO-CONTROLLED TRIAL, D ENDOCRINE SYSTEM, MULTIPLE-SCLEROSIS ACTIVITY, PARATHYROID-HORMONE LEVELS, DIFFERENT MONTHLY REGIMENS, BETA-CELL FUNCTION, D-BINDING PROTEIN

Downloads

  • Vitamin D supplementation in the prevention and management of.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 953.74 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Cianferotti, Luisella, Francesco Bertoldo, Heike A Bischoff-Ferrari, Olivier Bruyere, Cyrus Cooper, Maurizio Cutolo, John A Kanis, et al. 2017. “Vitamin D Supplementation in the Prevention and Management of Major Chronic Diseases Not Related to Mineral Homeostasis in Adults : Research for Evidence and a Scientific Statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).” Endocrine 56 (2): 245–261.
APA
Cianferotti, L., Bertoldo, F., Bischoff-Ferrari, H. A., Bruyere, O., Cooper, C., Cutolo, M., Kanis, J. A., et al. (2017). Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults : research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO). ENDOCRINE, 56(2), 245–261.
Vancouver
1.
Cianferotti L, Bertoldo F, Bischoff-Ferrari HA, Bruyere O, Cooper C, Cutolo M, et al. Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults : research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO). ENDOCRINE. 2017;56(2):245–61.
MLA
Cianferotti, Luisella et al. “Vitamin D Supplementation in the Prevention and Management of Major Chronic Diseases Not Related to Mineral Homeostasis in Adults : Research for Evidence and a Scientific Statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).” ENDOCRINE 56.2 (2017): 245–261. Print.
@article{8525313,
  abstract     = {Introduction: Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. 
Purpose and Methods: Members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis have reviewed the main evidence for possible proven benefits of vitamin D supplementation in adults at risk of or with overt chronic extra-skeletal diseases, providing recommendations and guidelines for future studies in this field. 
Results and conclusions: Robust mechanistic evidence is available from in vitro studies and in vivo animal studies, usually employing cholecalciferol, calcidiol or calcitriol in pharmacologic rather than physiologic doses. Although many cross-sectional and prospective association studies in humans have shown that low 25-hydroxyvitamin D levels (i.e., < 50 nmol/L) are consistently associated with chronic diseases, further strengthened by a dose-response relationship, several meta-analyses of clinical trials have shown contradictory results. Overall, large randomized controlled trials with sufficient doses of vitamin D are missing, and available small to moderate-size trials often included people with baseline levels of serum 25-hydroxyvitamin D levels > 50 nmol/L, did not simultaneously assess multiple outcomes, and did not report overall safety (e.g., falls). Thus, no recommendations can be made to date for the use of vitamin D supplementation in general, parental compounds, or non-hypercalcemic vitamin D analogs in the prevention and treatment of extra-skeletal chronic diseases. Moreover, attainment of serum 25-hydroxyvitamin D levels well above the threshold desired for bone health cannot be recommended based on current evidence, since safety has yet to be confirmed. Finally, the promising findings from mechanistic studies, large cohort studies, and small clinical trials obtained for autoimmune diseases (including type 1 diabetes, multiple sclerosis, and systemic lupus erythematosus), cardiovascular disorders, and overall reduction in mortality require further confirmation.},
  author       = {Cianferotti, Luisella and Bertoldo, Francesco and Bischoff-Ferrari, Heike A and Bruyere, Olivier and Cooper, Cyrus and Cutolo, Maurizio and Kanis, John A and Kaufman, Jean and Reginster, Jean-Yves and Rizzoli, Rene and Brandi, Maria Luisa},
  issn         = {1355-008X},
  journal      = {ENDOCRINE},
  keywords     = {Cholecalciferol,Cancer,Diabetes,Mortality,Cardiovascular diseases,Autoimmune diseases,RANDOMIZED CONTROLLED-TRIAL,SYSTEMIC-LUPUS-ERYTHEMATOSUS,SERUM 25-HYDROXYVITAMIN D,PLACEBO-CONTROLLED TRIAL,D ENDOCRINE SYSTEM,MULTIPLE-SCLEROSIS ACTIVITY,PARATHYROID-HORMONE LEVELS,DIFFERENT MONTHLY REGIMENS,BETA-CELL FUNCTION,D-BINDING PROTEIN},
  language     = {eng},
  number       = {2},
  pages        = {245--261},
  title        = {Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults : research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO)},
  url          = {http://dx.doi.org/10.1007/s12020-017-1290-9},
  volume       = {56},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: