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Pediatric lupus nephritis presenting with terminal renal failure

MARTINE BESOUW (UGent) , Johan Vande Walle (UGent) , Mohamad Ikram Ilias (UGent) , Ann Raes (UGent) , Agnieszka Prytula-Ebels (UGent) , Lieve Claeys and Jo Dehoorne (UGent)
(2016) ACTA CLINICA BELGICA. 71(6). p.455-457
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Abstract
A 12-year-old Congolese girl presented with acute renal failure, edema, hypertension, hemoptysis, hematuria, and proteinuria after a history of throat infection. Renal ultrasound showed kidneys of normal size, with increased echogenicity of the cortical parenchyma and decreased corticomedullary differentiation. Other additional investigations showed pancytopenia with decreased complement (low C3 and C4). Antinuclear antibodies were strongly positive, including anti-double stranded DNA. Renal biopsy confirmed severe grade IV lupus nephritis. She was treated with high-dose steroids, mycophenolate mofetil and hydroxychloroquine, in addition to hemodialysis. After oneweek of intensive treatment, diuresis recovered and dialysis could be stopped after six sessions. We describe an uncommon case of severe lupus nephritis, presenting with terminal renal failure. Since the rarity of this disease presentation, other more common diagnoses have to be considered. Once the diagnosis of lupus nephritis is established, a choice has to be made between the different induction treatment protocols. The patient's ethnic background and other supportive therapies, such as the need for dialysis, can help to make this choice.
Keywords
Systemic lupus erythematosus, Lupus nephritis, Acute renal failure, Terminal renal failure, Dialysis, Differential diagnosis

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MLA
BESOUW, MARTINE, et al. “Pediatric Lupus Nephritis Presenting with Terminal Renal Failure.” ACTA CLINICA BELGICA, vol. 71, no. 6, 2016, pp. 455–57, doi:10.1080/17843286.2016.1159383.
APA
BESOUW, M., Vande Walle, J., Ilias, M. I., Raes, A., Prytula-Ebels, A., Claeys, L., & Dehoorne, J. (2016). Pediatric lupus nephritis presenting with terminal renal failure. ACTA CLINICA BELGICA, 71(6), 455–457. https://doi.org/10.1080/17843286.2016.1159383
Chicago author-date
BESOUW, MARTINE, Johan Vande Walle, Mohamad Ikram Ilias, Ann Raes, Agnieszka Prytula-Ebels, Lieve Claeys, and Jo Dehoorne. 2016. “Pediatric Lupus Nephritis Presenting with Terminal Renal Failure.” ACTA CLINICA BELGICA 71 (6): 455–57. https://doi.org/10.1080/17843286.2016.1159383.
Chicago author-date (all authors)
BESOUW, MARTINE, Johan Vande Walle, Mohamad Ikram Ilias, Ann Raes, Agnieszka Prytula-Ebels, Lieve Claeys, and Jo Dehoorne. 2016. “Pediatric Lupus Nephritis Presenting with Terminal Renal Failure.” ACTA CLINICA BELGICA 71 (6): 455–457. doi:10.1080/17843286.2016.1159383.
Vancouver
1.
BESOUW M, Vande Walle J, Ilias MI, Raes A, Prytula-Ebels A, Claeys L, et al. Pediatric lupus nephritis presenting with terminal renal failure. ACTA CLINICA BELGICA. 2016;71(6):455–7.
IEEE
[1]
M. BESOUW et al., “Pediatric lupus nephritis presenting with terminal renal failure,” ACTA CLINICA BELGICA, vol. 71, no. 6, pp. 455–457, 2016.
@article{8525098,
  abstract     = {{A 12-year-old Congolese girl presented with acute renal failure, edema, hypertension, hemoptysis, hematuria, and proteinuria after a history of throat infection. Renal ultrasound showed kidneys of normal size, with increased echogenicity of the cortical parenchyma and decreased corticomedullary differentiation. Other additional investigations showed pancytopenia with decreased complement (low C3 and C4). Antinuclear antibodies were strongly positive, including anti-double stranded DNA. Renal biopsy confirmed severe grade IV lupus nephritis. She was treated with high-dose steroids, mycophenolate mofetil and hydroxychloroquine, in addition to hemodialysis. After oneweek of intensive treatment, diuresis recovered and dialysis could be stopped after six sessions. We describe an uncommon case of severe lupus nephritis, presenting with terminal renal failure. Since the rarity of this disease presentation, other more common diagnoses have to be considered. Once the diagnosis of lupus nephritis is established, a choice has to be made between the different induction treatment protocols. The patient's ethnic background and other supportive therapies, such as the need for dialysis, can help to make this choice.}},
  author       = {{BESOUW, MARTINE and Vande Walle, Johan and Ilias, Mohamad Ikram and Raes, Ann and Prytula-Ebels, Agnieszka and Claeys, Lieve and Dehoorne, Jo}},
  issn         = {{1784-3286}},
  journal      = {{ACTA CLINICA BELGICA}},
  keywords     = {{Systemic lupus erythematosus,Lupus nephritis,Acute renal failure,Terminal renal failure,Dialysis,Differential diagnosis}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{455--457}},
  title        = {{Pediatric lupus nephritis presenting with terminal renal failure}},
  url          = {{http://doi.org/10.1080/17843286.2016.1159383}},
  volume       = {{71}},
  year         = {{2016}},
}

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