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Age- and strain-dependent differences in the outcome of experimental infections of domestic pigs with wild boar pseudorabies virus isolates

Sara Verpoest, Ann Brigitte Cay, Willem Van Campe, Laurent Mostin, Sarah Welby, Herman Favoreel UGent and Nick De Regge UGent (2016) JOURNAL OF GENERAL VIROLOGY. 97(2). p.487-495
abstract
Although pseudorabies virus (PRV) has been eradicated in domestic swine in many countries, its presence in wild boars remains a threat for a reintroduction into the currently unprotected swine population. To assess the possible impact of such a reintroduction in a naive herd, an in vivo infection study using two genetically characterized wild boar PRV isolates (BEL24043 and BEL20075) representative for wild boar strains circulating in south-western and central Europe and the virulent NIA3 reference strain was performed in 2- and 15-week-old domestic pigs. Our study revealed an attenuated nature of both wild boar strains in 15-week-old pigs. In contrast, it showed the capacity of strain BEL24043 to induce severe clinical symptoms and mortality in young piglets, thereby confirming that the known age dependency of disease outcome after PRV infection also holds for wild boar isolates. Despite the absence of clinical disease in 15-week-old sows, both wild boar PRV strains were able to induce seroconversion, but to a different extent. Importantly, differences in infection and transmission capacity of both strains were observed in 15-week-old sows. Strain BEL24043 induced a more prolonged and disseminated infection than strain BEL20075 and was able to spread efficiently to contact animals, indicative of its capacity to induce a sustained infection. In conclusion, it was shown that a reintroduction of a wild boar isolate into the domestic swine population could have serious economic consequences due to the induction of clinical symptoms in piglets and by jeopardizing the PRV-negative status.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
AUJESZKYS-DISEASE, FERAL SWINE, TRANSMISSION, USA
journal title
JOURNAL OF GENERAL VIROLOGY
J. Gen. Virol.
volume
97
issue
2
pages
487 - 495
Web of Science type
Article
Web of Science id
000372063600025
JCR category
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
JCR impact factor
2.838 (2016)
JCR rank
54/158 (2016)
JCR quartile
2 (2016)
ISSN
0022-1317
1465-2099
DOI
10.1099/jgv.0.000347
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8525086
handle
http://hdl.handle.net/1854/LU-8525086
date created
2017-06-26 11:18:27
date last changed
2017-07-04 14:39:07
@article{8525086,
  abstract     = {Although pseudorabies virus (PRV) has been eradicated in domestic swine in many countries, its presence in wild boars remains a threat for a reintroduction into the currently unprotected swine population. To assess the possible impact of such a reintroduction in a naive herd, an in vivo infection study using two genetically characterized wild boar PRV isolates (BEL24043 and BEL20075) representative for wild boar strains circulating in south-western and central Europe and the virulent NIA3 reference strain was performed in 2- and 15-week-old domestic pigs. Our study revealed an attenuated nature of both wild boar strains in 15-week-old pigs. In contrast, it showed the capacity of strain BEL24043 to induce severe clinical symptoms and mortality in young piglets, thereby confirming that the known age dependency of disease outcome after PRV infection also holds for wild boar isolates. Despite the absence of clinical disease in 15-week-old sows, both wild boar PRV strains were able to induce seroconversion, but to a different extent. Importantly, differences in infection and transmission capacity of both strains were observed in 15-week-old sows. Strain BEL24043 induced a more prolonged and disseminated infection than strain BEL20075 and was able to spread efficiently to contact animals, indicative of its capacity to induce a sustained infection. In conclusion, it was shown that a reintroduction of a wild boar isolate into the domestic swine population could have serious economic consequences due to the induction of clinical symptoms in piglets and by jeopardizing the PRV-negative status.},
  author       = {Verpoest, Sara and Cay, Ann Brigitte and Van Campe, Willem and Mostin, Laurent and Welby, Sarah and Favoreel, Herman and De Regge, Nick},
  issn         = {0022-1317},
  journal      = {JOURNAL OF GENERAL VIROLOGY},
  keyword      = {AUJESZKYS-DISEASE,FERAL SWINE,TRANSMISSION,USA},
  language     = {eng},
  number       = {2},
  pages        = {487--495},
  title        = {Age- and strain-dependent differences in the outcome of experimental infections of domestic pigs with wild boar pseudorabies virus isolates},
  url          = {http://dx.doi.org/10.1099/jgv.0.000347},
  volume       = {97},
  year         = {2016},
}

Chicago
Verpoest, Sara, Ann Brigitte Cay, Willem Van Campe, Laurent Mostin, Sarah Welby, Herman Favoreel, and Nick De Regge. 2016. “Age- and Strain-dependent Differences in the Outcome of Experimental Infections of Domestic Pigs with Wild Boar Pseudorabies Virus Isolates.” Journal of General Virology 97 (2): 487–495.
APA
Verpoest, S., Cay, A. B., Van Campe, W., Mostin, L., Welby, S., Favoreel, H., & De Regge, N. (2016). Age- and strain-dependent differences in the outcome of experimental infections of domestic pigs with wild boar pseudorabies virus isolates. JOURNAL OF GENERAL VIROLOGY, 97(2), 487–495.
Vancouver
1.
Verpoest S, Cay AB, Van Campe W, Mostin L, Welby S, Favoreel H, et al. Age- and strain-dependent differences in the outcome of experimental infections of domestic pigs with wild boar pseudorabies virus isolates. JOURNAL OF GENERAL VIROLOGY. 2016;97(2):487–95.
MLA
Verpoest, Sara, Ann Brigitte Cay, Willem Van Campe, et al. “Age- and Strain-dependent Differences in the Outcome of Experimental Infections of Domestic Pigs with Wild Boar Pseudorabies Virus Isolates.” JOURNAL OF GENERAL VIROLOGY 97.2 (2016): 487–495. Print.