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Analysis of HER2 expression and gene amplification in adenocarcinoma of the stomach and the gastro-oesophageal junction : rationale for the Belgian way of working

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Abstract
The Human Epidermal growth factor Receptor 2 (HER2) has been established as a key player in the development of certain human tumors. ToGA trial has demonstrated that the addition of the monoclonal antibody blocking HER2 receptor, trastuzumab (Herceptin (R)), to chemotherapy significantly improves overall survival of patients with HER2-positive advanced or metastatic adenocarcinoma of the stomach or gastro-oesophageal junction. Therefore, it is essential that pathologists guarantee an accurate testing of HER2 status in these tumours. Following the international recommendations and the Belgian criteria for reimbursement of trastuzumab, a consortium of expert pathologists (Belgian Working Group Molecular Pathology) proposes an adaptation of the international guidelines in order to develop strategies for optimal performance, interpretation and reporting assays.
Keywords
HER2 testing, gastric cancer, gastro-oesophageal junction cancer, immunohistochemistry, in situ hybridisation, trastuzumab, GROWTH-FACTOR RECEPTOR, IN-SITU HYBRIDIZATION, HUMAN-BREAST-CANCER, GASTRIC-CANCER, CLINICAL-SIGNIFICANCE, CARCINOMA, VALIDATION, SURVIVAL, ONCOGENE

Citation

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Chicago
Jouret-Mourin, A, Anne Hoorens, G De Hertogh, J Vanderveken, P Demetter, and E Van Cutsem. 2012. “Analysis of HER2 Expression and Gene Amplification in Adenocarcinoma of the Stomach and the Gastro-oesophageal Junction : Rationale for the Belgian Way of Working.” Acta Gastro-enterologica Belgica 75 (1): 9–13.
APA
Jouret-Mourin, A., Hoorens, A., De Hertogh, G., Vanderveken, J., Demetter, P., & Van Cutsem, E. (2012). Analysis of HER2 expression and gene amplification in adenocarcinoma of the stomach and the gastro-oesophageal junction : rationale for the Belgian way of working. ACTA GASTRO-ENTEROLOGICA BELGICA, 75(1), 9–13.
Vancouver
1.
Jouret-Mourin A, Hoorens A, De Hertogh G, Vanderveken J, Demetter P, Van Cutsem E. Analysis of HER2 expression and gene amplification in adenocarcinoma of the stomach and the gastro-oesophageal junction : rationale for the Belgian way of working. ACTA GASTRO-ENTEROLOGICA BELGICA. 2012;75(1):9–13.
MLA
Jouret-Mourin, A, Anne Hoorens, G De Hertogh, et al. “Analysis of HER2 Expression and Gene Amplification in Adenocarcinoma of the Stomach and the Gastro-oesophageal Junction : Rationale for the Belgian Way of Working.” ACTA GASTRO-ENTEROLOGICA BELGICA 75.1 (2012): 9–13. Print.
@article{8524873,
  abstract     = {The Human Epidermal growth factor Receptor 2 (HER2) has been established as a key player in the development of certain human tumors. ToGA trial has demonstrated that the addition of the monoclonal antibody blocking HER2 receptor, trastuzumab (Herceptin (R)), to chemotherapy significantly improves overall survival of patients with HER2-positive advanced or metastatic adenocarcinoma of the stomach or gastro-oesophageal junction. Therefore, it is essential that pathologists guarantee an accurate testing of HER2 status in these tumours. Following the international recommendations and the Belgian criteria for reimbursement of trastuzumab, a consortium of expert pathologists (Belgian Working Group Molecular Pathology) proposes an adaptation of the international guidelines in order to develop strategies for optimal performance, interpretation and reporting assays.},
  author       = {Jouret-Mourin, A and Hoorens, Anne and De Hertogh, G and Vanderveken, J and Demetter, P and Van Cutsem, E},
  issn         = {0001-5644},
  journal      = {ACTA GASTRO-ENTEROLOGICA BELGICA},
  keyword      = {HER2 testing,gastric cancer,gastro-oesophageal junction cancer,immunohistochemistry,in situ hybridisation,trastuzumab,GROWTH-FACTOR RECEPTOR,IN-SITU HYBRIDIZATION,HUMAN-BREAST-CANCER,GASTRIC-CANCER,CLINICAL-SIGNIFICANCE,CARCINOMA,VALIDATION,SURVIVAL,ONCOGENE},
  language     = {eng},
  number       = {1},
  pages        = {9--13},
  title        = {Analysis of HER2 expression and gene amplification in adenocarcinoma of the stomach and the gastro-oesophageal junction : rationale for the Belgian way of working},
  volume       = {75},
  year         = {2012},
}

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