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Noncoding after all : biases in proteomics data do not explain observed absence of lncRNA translation products

Kenneth Verheggen UGent, Pieter-Jan Volders UGent, Pieter Mestdagh UGent, Gerben Menschaert UGent, Petra Van Damme UGent, Kris Gevaert UGent, Lennart Martens UGent and Jo Vandesompele UGent (2017) JOURNAL OF PROTEOME RESEARCH. 16(7). p.2508-2515
abstract
Over the past decade, long noncoding RNAs (lncRNAs) have emerged as novel functional entities of the eukaryotic genome. However, the scientific community remains divided over the amount of true noncoding transcripts among the large number of unannotated transcripts identified by recent large scale and deep RNA-sequencing efforts. Here, we systematically exclude possible technical reasons underlying the absence of lncRNA-encoded proteins in mass spectrometry data sets, strongly suggesting that the large majority of lncRNAs is indeed not translated.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
public data, lncRNA, mass spectrometry, msms, micropeptide, translation, PROVIDES EVIDENCE, PROTEIN, RNAS, REVEALS, CELLS, IDENTIFICATION, LANDSCAPE, SEQUENCE
journal title
JOURNAL OF PROTEOME RESEARCH
J. Proteome Res.
volume
16
issue
7
pages
2508 - 2515
Web of Science type
Article
Web of Science id
000405358500017
ISSN
1535-3893
1535-3907
DOI
10.1021/acs.jproteome.7b00085
project
Bioinformatics: from nucleotids to networks (N2N)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8524743
handle
http://hdl.handle.net/1854/LU-8524743
date created
2017-06-22 12:15:24
date last changed
2017-11-07 15:07:18
@article{8524743,
  abstract     = {Over the past decade, long noncoding RNAs (lncRNAs) have emerged as novel functional entities of the eukaryotic genome. However, the scientific community remains divided over the amount of true noncoding transcripts among the large number of unannotated transcripts identified by recent large scale and deep RNA-sequencing efforts. Here, we systematically exclude possible technical reasons underlying the absence of lncRNA-encoded proteins in mass spectrometry data sets, strongly suggesting that the large majority of lncRNAs is indeed not translated.},
  author       = {Verheggen, Kenneth and Volders, Pieter-Jan and Mestdagh, Pieter and Menschaert, Gerben and Van Damme, Petra and Gevaert, Kris and Martens, Lennart and Vandesompele, Jo},
  issn         = {1535-3893},
  journal      = {JOURNAL OF PROTEOME RESEARCH},
  keyword      = {public data,lncRNA,mass spectrometry,msms,micropeptide,translation,PROVIDES EVIDENCE,PROTEIN,RNAS,REVEALS,CELLS,IDENTIFICATION,LANDSCAPE,SEQUENCE},
  language     = {eng},
  number       = {7},
  pages        = {2508--2515},
  title        = {Noncoding after all : biases in proteomics data do not explain observed absence of lncRNA translation products},
  url          = {http://dx.doi.org/10.1021/acs.jproteome.7b00085},
  volume       = {16},
  year         = {2017},
}

Chicago
Verheggen, Kenneth, Pieter-Jan Volders, Pieter Mestdagh, Gerben Menschaert, Petra Van Damme, Kris Gevaert, Lennart Martens, and Jo Vandesompele. 2017. “Noncoding After All : Biases in Proteomics Data Do Not Explain Observed Absence of lncRNA Translation Products.” Journal of Proteome Research 16 (7): 2508–2515.
APA
Verheggen, K., Volders, P.-J., Mestdagh, P., Menschaert, G., Van Damme, P., Gevaert, K., Martens, L., et al. (2017). Noncoding after all : biases in proteomics data do not explain observed absence of lncRNA translation products. JOURNAL OF PROTEOME RESEARCH, 16(7), 2508–2515.
Vancouver
1.
Verheggen K, Volders P-J, Mestdagh P, Menschaert G, Van Damme P, Gevaert K, et al. Noncoding after all : biases in proteomics data do not explain observed absence of lncRNA translation products. JOURNAL OF PROTEOME RESEARCH. 2017;16(7):2508–15.
MLA
Verheggen, Kenneth, Pieter-Jan Volders, Pieter Mestdagh, et al. “Noncoding After All : Biases in Proteomics Data Do Not Explain Observed Absence of lncRNA Translation Products.” JOURNAL OF PROTEOME RESEARCH 16.7 (2017): 2508–2515. Print.