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Influence of microRNAs and long non-coding RNAs in cancer chemoresistance

Duncan Ayers and Jo Vandesompele UGent (2017) GENES. 8(3).
abstract
Innate and acquired chemoresistance exhibited by most tumours exposed to conventional chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such chemoresistance phenotypes are of a multi-factorial nature from multiple key molecular players. The discovery of the RNA interference pathway in 1998 and the widespread gene regulatory influences exerted by microRNAs (miRNAs) and other non-coding RNAs have certainly expanded the level of intricacy present for the development of any single physiological phenotype, including cancer chemoresistance. This review article focuses on the latest research efforts in identifying and validating specific key molecular players from the two main families of non-coding RNAs, namely miRNAs and long non-coding RNAs (lncRNAs), having direct or indirect influences in the development of cancer drug resistance properties and how such knowledge can be utilised for novel theranostics in oncology.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
miRNA, lncRNA, cancer, chemoresistance, drug resistance, tumour, microRNA, CELL LUNG-CANCER, HEPATOCELLULAR-CARCINOMA CELLS, EPITHELIAL-MESENCHYMAL TRANSITION, CISPLATIN-INDUCED APOPTOSIS, HUMAN BREAST-CANCER, NRF2-DEPENDENT ANTIOXIDANT PATHWAY, RESISTANCE-ASSOCIATED PROTEIN-1, DNA-DAMAGE RESPONSE, NF-KAPPA-B, OVARIAN-CANCER
journal title
GENES
Genes
volume
8
issue
3
article number
95
pages
34 pages
Web of Science type
Review
Web of Science id
000399058500011
ISSN
2073-4425
DOI
10.3390/genes8030095
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8524591
handle
http://hdl.handle.net/1854/LU-8524591
date created
2017-06-21 12:49:20
date last changed
2017-09-25 07:45:09
@article{8524591,
  abstract     = {Innate and acquired chemoresistance exhibited by most tumours exposed to conventional chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such chemoresistance phenotypes are of a multi-factorial nature from multiple key molecular players. The discovery of the RNA interference pathway in 1998 and the widespread gene regulatory influences exerted by microRNAs (miRNAs) and other non-coding RNAs have certainly expanded the level of intricacy present for the development of any single physiological phenotype, including cancer chemoresistance. This review article focuses on the latest research efforts in identifying and validating specific key molecular players from the two main families of non-coding RNAs, namely miRNAs and long non-coding RNAs (lncRNAs), having direct or indirect influences in the development of cancer drug resistance properties and how such knowledge can be utilised for novel theranostics in oncology.},
  articleno    = {95},
  author       = {Ayers, Duncan and Vandesompele, Jo},
  issn         = {2073-4425},
  journal      = {GENES},
  keyword      = {miRNA,lncRNA,cancer,chemoresistance,drug resistance,tumour,microRNA,CELL LUNG-CANCER,HEPATOCELLULAR-CARCINOMA CELLS,EPITHELIAL-MESENCHYMAL TRANSITION,CISPLATIN-INDUCED APOPTOSIS,HUMAN BREAST-CANCER,NRF2-DEPENDENT ANTIOXIDANT PATHWAY,RESISTANCE-ASSOCIATED PROTEIN-1,DNA-DAMAGE RESPONSE,NF-KAPPA-B,OVARIAN-CANCER},
  language     = {eng},
  number       = {3},
  pages        = {34},
  title        = {Influence of microRNAs and long non-coding RNAs in cancer chemoresistance},
  url          = {http://dx.doi.org/10.3390/genes8030095},
  volume       = {8},
  year         = {2017},
}

Chicago
Ayers, Duncan, and Jo Vandesompele. 2017. “Influence of microRNAs and Long Non-coding RNAs in Cancer Chemoresistance.” Genes 8 (3).
APA
Ayers, D., & Vandesompele, J. (2017). Influence of microRNAs and long non-coding RNAs in cancer chemoresistance. GENES, 8(3).
Vancouver
1.
Ayers D, Vandesompele J. Influence of microRNAs and long non-coding RNAs in cancer chemoresistance. GENES. 2017;8(3).
MLA
Ayers, Duncan, and Jo Vandesompele. “Influence of microRNAs and Long Non-coding RNAs in Cancer Chemoresistance.” GENES 8.3 (2017): n. pag. Print.