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A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties

(2017) CELL REPORTS. 19(7). p.1431-1443
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Abstract
The Ly49E receptor is preferentially expressed on murine innate-like lymphocytes, such as epidermal V gamma 3 T cells, intestinal intraepithelial CD8 alpha alpha(+) T lymphocytes, and CD49a(+) liver natural killer (NK) cells. As the latter have recently been shown to be distinct from conventional NK cells and have innate lymphoid cell type 1 (ILC1) properties, we investigated Ly49E expression on intestinal ILC populations. Here, we show that Ly49E expression is very low on known ILC populations, but it can be used to define a previously unrecognized intraepithelial innate lymphoid population. This Ly49E-positive population is negative for NKp46 and CD8 alpha alpha, expresses CD49a and CD103, and requires T-bet expression and IL-15 signaling for differentiation and/or survival. Transcriptome analysis reveals a group 1 ILC gene profile, different from NK cells, iCD8 alpha cells, and intraepithelial ILC1. Importantly, NKp46(-)CD8 alpha alpha(-)Ly49E(+) cells produce interferon (IFN)-gamma, suggesting that this previously unrecognized population may contribute to Th1-mediated immunity.
Keywords
ROR-GAMMA-T, NK-CELLS, INHIBITORY RECEPTORS, NATURAL-KILLER, NKP46(+) CELLS, IFN-GAMMA, EXPRESSION, DIFFERENTIATION, LYMPHOCYTES, SUBSETS

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Chicago
Van Acker, Aline, Konrad Gronke, Aindrila Biswas, Liesbet Martens, Yvan Saeys, Jessica Filtjens, Sylvie Taveirne, et al. 2017. “A Murine Intestinal Intraepithelial NKp46-negative Innate Lymphoid Cell Population Characterized by Group 1 Properties.” Cell Reports 19 (7): 1431–1443.
APA
Van Acker, A., Gronke, K., Biswas, A., Martens, L., Saeys, Y., Filtjens, J., Taveirne, S., et al. (2017). A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties. CELL REPORTS, 19(7), 1431–1443.
Vancouver
1.
Van Acker A, Gronke K, Biswas A, Martens L, Saeys Y, Filtjens J, et al. A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties. CELL REPORTS. 2017;19(7):1431–43.
MLA
Van Acker, Aline, Konrad Gronke, Aindrila Biswas, et al. “A Murine Intestinal Intraepithelial NKp46-negative Innate Lymphoid Cell Population Characterized by Group 1 Properties.” CELL REPORTS 19.7 (2017): 1431–1443. Print.
@article{8524067,
  abstract     = {The Ly49E receptor is preferentially expressed on murine innate-like lymphocytes, such as epidermal V gamma 3 T cells, intestinal intraepithelial CD8 alpha alpha(+) T lymphocytes, and CD49a(+) liver natural killer (NK) cells. As the latter have recently been shown to be distinct from conventional NK cells and have innate lymphoid cell type 1 (ILC1) properties, we investigated Ly49E expression on intestinal ILC populations. Here, we show that Ly49E expression is very low on known ILC populations, but it can be used to define a previously unrecognized intraepithelial innate lymphoid population. This Ly49E-positive population is negative for NKp46 and CD8 alpha alpha, expresses CD49a and CD103, and requires T-bet expression and IL-15 signaling for differentiation and/or survival. Transcriptome analysis reveals a group 1 ILC gene profile, different from NK cells, iCD8 alpha cells, and intraepithelial ILC1. Importantly, NKp46(-)CD8 alpha alpha(-)Ly49E(+) cells produce interferon (IFN)-gamma, suggesting that this previously unrecognized population may contribute to Th1-mediated immunity.},
  author       = {Van Acker, Aline and Gronke, Konrad and Biswas, Aindrila and Martens, Liesbet and Saeys, Yvan and Filtjens, Jessica and Taveirne, Sylvie and Van Ammel, Els and Kerre, Tessa and Matthys, Patrick and Taghon, Tom and Vandekerckhove, Bart and Plum, Jean and Dunay, Ildiko Rita and Diefenbach, Andreas and Leclercq, Georges},
  issn         = {2211-1247},
  journal      = {CELL REPORTS},
  language     = {eng},
  number       = {7},
  pages        = {1431--1443},
  title        = {A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties},
  url          = {http://dx.doi.org/10.1016/j.celrep.2017.04.068},
  volume       = {19},
  year         = {2017},
}

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