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IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells

(2008) JOURNAL OF IMMUNOLOGY. 181(5). p.3665-3673
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Abstract
The role of specific CD4(+) T cell subsets in the induction of Immoral immune responses in humans is largely unknown. In this study, the generation of hepatitis B surface Ag-specific CD4(+) T lymphocytes following vaccination was closely monitored and characterized at the single-cell level. The appearance and absolute numbers of hepatitis B surface Ag-specific IL-2 producing effector memory CD4(+) T lymphocytes was solely and tightly related to Ab titers reached. This relation remained present many years after vaccination. Subsequently, a relation was found between Ab titers and number of IL-2 producing memory CD4(+) T lymphocytes for various other Ags. These observations matched the findings of an in vitro assay, using different T cell subsets to induce B cell differentiation into IgG-producing plasma cells. By depleting for IL-2 producing memory T cells, we demonstrated that these cells are important for B cell differentiation into IgG-producing plasma cells. Finally, blocking the action of IL-2 with an IL-2R-alpha Ab inhibited the differentiation of B lymphocytes into IgG-producing plasma cells. Based on these findings, we conclude that the development of Ag-specific IL-2-producing memory T cells appears to be essential for the development of IgG-secreting plasma cells in humans.
Keywords
HEPATITIS-B VACCINATION, CHRONIC KIDNEY-DISEASE, DENDRITIC CELLS, HEMODIALYSIS-PATIENTS, RESPONSES, EFFECTOR, ANTIBODY, PROTEIN, DIFFERENTIATION, IMMUNIZATION

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Citation

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MLA
Litjens, Nicolle HR, et al. “IL-2 Producing Memory CD4+ T Lymphocytes Are Closely Associated with the Generation of IgG-Secreting Plasma Cells.” JOURNAL OF IMMUNOLOGY, vol. 181, no. 5, 2008, pp. 3665–73.
APA
Litjens, N. H., Huisman, M., Hijdra, D., Lambrecht, B., Stittelaar, K. J., & Betjes, M. G. (2008). IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells. JOURNAL OF IMMUNOLOGY, 181(5), 3665–3673.
Chicago author-date
Litjens, Nicolle HR, Martin Huisman, Danielle Hijdra, Bart Lambrecht, Koert J Stittelaar, and Michiel GH Betjes. 2008. “IL-2 Producing Memory CD4+ T Lymphocytes Are Closely Associated with the Generation of IgG-Secreting Plasma Cells.” JOURNAL OF IMMUNOLOGY 181 (5): 3665–73.
Chicago author-date (all authors)
Litjens, Nicolle HR, Martin Huisman, Danielle Hijdra, Bart Lambrecht, Koert J Stittelaar, and Michiel GH Betjes. 2008. “IL-2 Producing Memory CD4+ T Lymphocytes Are Closely Associated with the Generation of IgG-Secreting Plasma Cells.” JOURNAL OF IMMUNOLOGY 181 (5): 3665–3673.
Vancouver
1.
Litjens NH, Huisman M, Hijdra D, Lambrecht B, Stittelaar KJ, Betjes MG. IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells. JOURNAL OF IMMUNOLOGY. 2008;181(5):3665–73.
IEEE
[1]
N. H. Litjens, M. Huisman, D. Hijdra, B. Lambrecht, K. J. Stittelaar, and M. G. Betjes, “IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells,” JOURNAL OF IMMUNOLOGY, vol. 181, no. 5, pp. 3665–3673, 2008.
@article{8523847,
  abstract     = {{The role of specific CD4(+) T cell subsets in the induction of Immoral immune responses in humans is largely unknown. In this study, the generation of hepatitis B surface Ag-specific CD4(+) T lymphocytes following vaccination was closely monitored and characterized at the single-cell level. The appearance and absolute numbers of hepatitis B surface Ag-specific IL-2 producing effector memory CD4(+) T lymphocytes was solely and tightly related to Ab titers reached. This relation remained present many years after vaccination. Subsequently, a relation was found between Ab titers and number of IL-2 producing memory CD4(+) T lymphocytes for various other Ags. These observations matched the findings of an in vitro assay, using different T cell subsets to induce B cell differentiation into IgG-producing plasma cells. By depleting for IL-2 producing memory T cells, we demonstrated that these cells are important for B cell differentiation into IgG-producing plasma cells. Finally, blocking the action of IL-2 with an IL-2R-alpha Ab inhibited the differentiation of B lymphocytes into IgG-producing plasma cells. Based on these findings, we conclude that the development of Ag-specific IL-2-producing memory T cells appears to be essential for the development of IgG-secreting plasma cells in humans.}},
  author       = {{Litjens, Nicolle HR and Huisman, Martin and Hijdra, Danielle and Lambrecht, Bart and Stittelaar, Koert J and Betjes, Michiel GH}},
  issn         = {{0022-1767}},
  journal      = {{JOURNAL OF IMMUNOLOGY}},
  keywords     = {{HEPATITIS-B VACCINATION,CHRONIC KIDNEY-DISEASE,DENDRITIC CELLS,HEMODIALYSIS-PATIENTS,RESPONSES,EFFECTOR,ANTIBODY,PROTEIN,DIFFERENTIATION,IMMUNIZATION}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{3665--3673}},
  title        = {{IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells}},
  volume       = {{181}},
  year         = {{2008}},
}

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