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IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells

(2008) JOURNAL OF IMMUNOLOGY. 181(5). p.3665-3673
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Abstract
The role of specific CD4(+) T cell subsets in the induction of Immoral immune responses in humans is largely unknown. In this study, the generation of hepatitis B surface Ag-specific CD4(+) T lymphocytes following vaccination was closely monitored and characterized at the single-cell level. The appearance and absolute numbers of hepatitis B surface Ag-specific IL-2 producing effector memory CD4(+) T lymphocytes was solely and tightly related to Ab titers reached. This relation remained present many years after vaccination. Subsequently, a relation was found between Ab titers and number of IL-2 producing memory CD4(+) T lymphocytes for various other Ags. These observations matched the findings of an in vitro assay, using different T cell subsets to induce B cell differentiation into IgG-producing plasma cells. By depleting for IL-2 producing memory T cells, we demonstrated that these cells are important for B cell differentiation into IgG-producing plasma cells. Finally, blocking the action of IL-2 with an IL-2R-alpha Ab inhibited the differentiation of B lymphocytes into IgG-producing plasma cells. Based on these findings, we conclude that the development of Ag-specific IL-2-producing memory T cells appears to be essential for the development of IgG-secreting plasma cells in humans.
Keywords
HEPATITIS-B VACCINATION, CHRONIC KIDNEY-DISEASE, DENDRITIC CELLS, HEMODIALYSIS-PATIENTS, RESPONSES, EFFECTOR, ANTIBODY, PROTEIN, DIFFERENTIATION, IMMUNIZATION

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Citation

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Chicago
Litjens, Nicolle HR, Martin Huisman, Danielle Hijdra, Bart Lambrecht, Koert J Stittelaar, and Michiel GH Betjes. 2008. “IL-2 Producing Memory CD4+ T Lymphocytes Are Closely Associated with the Generation of IgG-secreting Plasma Cells.” Journal of Immunology 181 (5): 3665–3673.
APA
Litjens, N. H., Huisman, M., Hijdra, D., Lambrecht, B., Stittelaar, K. J., & Betjes, M. G. (2008). IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells. JOURNAL OF IMMUNOLOGY, 181(5), 3665–3673.
Vancouver
1.
Litjens NH, Huisman M, Hijdra D, Lambrecht B, Stittelaar KJ, Betjes MG. IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells. JOURNAL OF IMMUNOLOGY. 2008;181(5):3665–73.
MLA
Litjens, Nicolle HR et al. “IL-2 Producing Memory CD4+ T Lymphocytes Are Closely Associated with the Generation of IgG-secreting Plasma Cells.” JOURNAL OF IMMUNOLOGY 181.5 (2008): 3665–3673. Print.
@article{8523847,
  abstract     = {The role of specific CD4(+) T cell subsets in the induction of Immoral immune responses in humans is largely unknown. In this study, the generation of hepatitis B surface Ag-specific CD4(+) T lymphocytes following vaccination was closely monitored and characterized at the single-cell level. The appearance and absolute numbers of hepatitis B surface Ag-specific IL-2 producing effector memory CD4(+) T lymphocytes was solely and tightly related to Ab titers reached. This relation remained present many years after vaccination. Subsequently, a relation was found between Ab titers and number of IL-2 producing memory CD4(+) T lymphocytes for various other Ags. These observations matched the findings of an in vitro assay, using different T cell subsets to induce B cell differentiation into IgG-producing plasma cells. By depleting for IL-2 producing memory T cells, we demonstrated that these cells are important for B cell differentiation into IgG-producing plasma cells. Finally, blocking the action of IL-2 with an IL-2R-alpha Ab inhibited the differentiation of B lymphocytes into IgG-producing plasma cells. Based on these findings, we conclude that the development of Ag-specific IL-2-producing memory T cells appears to be essential for the development of IgG-secreting plasma cells in humans.},
  author       = {Litjens, Nicolle HR and Huisman, Martin and Hijdra, Danielle and Lambrecht, Bart and Stittelaar, Koert J and Betjes, Michiel GH},
  issn         = {0022-1767},
  journal      = {JOURNAL OF IMMUNOLOGY},
  keywords     = {HEPATITIS-B VACCINATION,CHRONIC KIDNEY-DISEASE,DENDRITIC CELLS,HEMODIALYSIS-PATIENTS,RESPONSES,EFFECTOR,ANTIBODY,PROTEIN,DIFFERENTIATION,IMMUNIZATION},
  language     = {eng},
  number       = {5},
  pages        = {3665--3673},
  title        = {IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells},
  volume       = {181},
  year         = {2008},
}

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