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Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote

Minako Ueda, Ernst Aichinger, Wen Gong, Edwin Groot, Inge Verstraeten UGent, Lam Dai Vu UGent, Ive De Smet UGent, Tetsuya Higashiyama, Masaaki Umeda and Thomas Laux (2017) GENES & DEVELOPMENT. 31(6). p.617-627
abstract
In many plants, the asymmetric division of the zygote sets up the apical-basal axis of the embryo. Unlike animals, plant zygotes are transcriptionally active, implying that plants have evolved specific mechanisms to control transcriptional activation of patterning genes in the zygote. In Arabidopsis, two pathways have been found to regulate zygote asymmetry: YODA (YDA) mitogen-activated protein kinase (MAPK) signaling, which is potentiated by sperm-delivered mRNA of the SHORT SUSPENSOR (SSP) membrane protein, and up-regulation of the patterning gene WOX8 by the WRKY2 transcription factor. How SSP/YDA signaling is transduced into the nucleus and how these pathways are integrated have remained elusive. Here we show that paternal SSP/YDA signaling directly phosphorylates WRKY2, which in turn leads to the up-regulation of WOX8 transcription in the zygote. We further discovered the transcription factors HOMEODOMAIN GLABROUS11/12 (HDG11/12) as maternal regulators of zygote asymmetry that also directly regulate WOX8 transcription. Our results reveal a framework of how maternal and paternal factors are integrated in the zygote to regulate embryo patterning.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
APICAL-BASAL AXIS, EMBRYO DEVELOPMENT, EARLY EMBRYOGENESIS, GENE-EXPRESSION, DNA METHYLATION, CELL FATE, THALIANA, DYNAMICS, ENDOSPERM, PROTEINS, zygote asymmetry, MAPK signaling, WOX8, maternal factors
journal title
GENES & DEVELOPMENT
Genes Dev.
volume
31
issue
6
pages
617 - 627
Web of Science type
Article
Web of Science id
000398890600007
ISSN
0890-9369
1549-5477
DOI
10.1101/gad.292409.116
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8523545
handle
http://hdl.handle.net/1854/LU-8523545
date created
2017-06-13 11:37:14
date last changed
2017-08-01 09:33:41
@article{8523545,
  abstract     = {In many plants, the asymmetric division of the zygote sets up the apical-basal axis of the embryo. Unlike animals, plant zygotes are transcriptionally active, implying that plants have evolved specific mechanisms to control transcriptional activation of patterning genes in the zygote. In Arabidopsis, two pathways have been found to regulate zygote asymmetry: YODA (YDA) mitogen-activated protein kinase (MAPK) signaling, which is potentiated by sperm-delivered mRNA of the SHORT SUSPENSOR (SSP) membrane protein, and up-regulation of the patterning gene WOX8 by the WRKY2 transcription factor. How SSP/YDA signaling is transduced into the nucleus and how these pathways are integrated have remained elusive. Here we show that paternal SSP/YDA signaling directly phosphorylates WRKY2, which in turn leads to the up-regulation of WOX8 transcription in the zygote. We further discovered the transcription factors HOMEODOMAIN GLABROUS11/12 (HDG11/12) as maternal regulators of zygote asymmetry that also directly regulate WOX8 transcription. Our results reveal a framework of how maternal and paternal factors are integrated in the zygote to regulate embryo patterning.},
  author       = {Ueda, Minako and Aichinger, Ernst and Gong, Wen and Groot, Edwin and Verstraeten, Inge and Vu, Lam Dai and De Smet, Ive and Higashiyama, Tetsuya and Umeda, Masaaki and Laux, Thomas},
  issn         = {0890-9369},
  journal      = {GENES \& DEVELOPMENT},
  keyword      = {APICAL-BASAL AXIS,EMBRYO DEVELOPMENT,EARLY EMBRYOGENESIS,GENE-EXPRESSION,DNA METHYLATION,CELL FATE,THALIANA,DYNAMICS,ENDOSPERM,PROTEINS,zygote asymmetry,MAPK signaling,WOX8,maternal factors},
  language     = {eng},
  number       = {6},
  pages        = {617--627},
  title        = {Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote},
  url          = {http://dx.doi.org/10.1101/gad.292409.116},
  volume       = {31},
  year         = {2017},
}

Chicago
Ueda, Minako, Ernst Aichinger, Wen Gong, Edwin Groot, Inge Verstraeten, Lam Dai Vu, Ive De Smet, Tetsuya Higashiyama, Masaaki Umeda, and Thomas Laux. 2017. “Transcriptional Integration of Paternal and Maternal Factors in the Arabidopsis Zygote.” Genes & Development 31 (6): 617–627.
APA
Ueda, M., Aichinger, E., Gong, W., Groot, E., Verstraeten, I., Vu, L. D., De Smet, I., et al. (2017). Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote. GENES & DEVELOPMENT, 31(6), 617–627.
Vancouver
1.
Ueda M, Aichinger E, Gong W, Groot E, Verstraeten I, Vu LD, et al. Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote. GENES & DEVELOPMENT. 2017;31(6):617–27.
MLA
Ueda, Minako, Ernst Aichinger, Wen Gong, et al. “Transcriptional Integration of Paternal and Maternal Factors in the Arabidopsis Zygote.” GENES & DEVELOPMENT 31.6 (2017): 617–627. Print.