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Sources of beta cells inside the pancreas

(2016) DIABETOLOGIA. 59(9). p.1834-1837
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Abstract
The generation of beta(-like) cells to compensate for their absolute or relative shortage in type 1 and type 2 diabetes is an obvious therapeutic strategy. Patients first received grafts of donor islet cells over 25 years ago, but this procedure has not become routine in clinical practice because of a donor cell shortage and (auto) immune problems. Transplantation of differentiated embryonic and induced pluripotent stem cells may overcome some but not all the current limitations. Reprogramming exocrine cells towards functional beta(-like) cells would offer an alternative abundant and autologous source of beta(-like) cells. This review focuses on work by our research group towards achieving such a source of cells. It summarises a presentation given at the 'Can we make a better beta cell?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Amin Ardestani and Kathrin Maedler, DOI: 10.1007/s0012-5016-3892-9, and by Heiko Lickert and colleagues, DOI: 10.1007/s00125-016-3949-9) and a commentary by the Session Chair, Shanta Persaud (DOI: 10.1007/s00125-016-3870-2).
Keywords
Beta cells, Diabetes, Exocrine pancreas, Growth factors, Injury, Macrophages, Proliferation, Regeneration, Review, Transcription factors, (Trans)differentiation, ADULT-MOUSE PANCREAS, EXOCRINE CELLS, DUCT LIGATION, PROLIFERATION, INJURY, DIFFERENTIATION, PROGENITORS, EXPANSION

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Citation

Please use this url to cite or link to this publication:

Chicago
De Groef, Sofie, Willem Staels, Naomi Van Gassen, Marie Lemper, Yixing Yuchi, Mozhdeh Sojoodi, Leen Bussche, et al. 2016. “Sources of Beta Cells Inside the Pancreas.” Diabetologia 59 (9): 1834–1837.
APA
De Groef, S., Staels, W., Van Gassen, N., Lemper, M., Yuchi, Y., Sojoodi, M., Bussche, L., et al. (2016). Sources of beta cells inside the pancreas. DIABETOLOGIA, 59(9), 1834–1837.
Vancouver
1.
De Groef S, Staels W, Van Gassen N, Lemper M, Yuchi Y, Sojoodi M, et al. Sources of beta cells inside the pancreas. DIABETOLOGIA. 2016;59(9):1834–7.
MLA
De Groef, Sofie, Willem Staels, Naomi Van Gassen, et al. “Sources of Beta Cells Inside the Pancreas.” DIABETOLOGIA 59.9 (2016): 1834–1837. Print.
@article{8523117,
  abstract     = {The generation of beta(-like) cells to compensate for their absolute or relative shortage in type 1 and type 2 diabetes is an obvious therapeutic strategy. Patients first received grafts of donor islet cells over 25 years ago, but this procedure has not become routine in clinical practice because of a donor cell shortage and (auto) immune problems. Transplantation of differentiated embryonic and induced pluripotent stem cells may overcome some but not all the current limitations. Reprogramming exocrine cells towards functional beta(-like) cells would offer an alternative abundant and autologous source of beta(-like) cells. This review focuses on work by our research group towards achieving such a source of cells. It summarises a presentation given at the 'Can we make a better beta cell?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Amin Ardestani and Kathrin Maedler, DOI: 10.1007/s0012-5016-3892-9, and by Heiko Lickert and colleagues, DOI: 10.1007/s00125-016-3949-9) and a commentary by the Session Chair, Shanta Persaud (DOI: 10.1007/s00125-016-3870-2).},
  author       = {De Groef, Sofie and Staels, Willem and Van Gassen, Naomi and Lemper, Marie and Yuchi, Yixing and Sojoodi, Mozhdeh and Bussche, Leen and Heremans, Yves and Leuckx, Gunter and De Leu, Nico and Van de Casteele, Mark and Baeyens, Luc and Heimberg, Harry},
  issn         = {0012-186X},
  journal      = {DIABETOLOGIA},
  keyword      = {Beta cells,Diabetes,Exocrine pancreas,Growth factors,Injury,Macrophages,Proliferation,Regeneration,Review,Transcription factors,(Trans)differentiation,ADULT-MOUSE PANCREAS,EXOCRINE CELLS,DUCT LIGATION,PROLIFERATION,INJURY,DIFFERENTIATION,PROGENITORS,EXPANSION},
  language     = {eng},
  number       = {9},
  pages        = {1834--1837},
  title        = {Sources of beta cells inside the pancreas},
  url          = {http://dx.doi.org/10.1007/s00125-016-3879-6},
  volume       = {59},
  year         = {2016},
}

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