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Sources of beta cells inside the pancreas

Sofie De Groef, Willem Staels UGent, Naomi Van Gassen, Marie Lemper, Yixing Yuchi, Mozhdeh Sojoodi, Leen Bussche, Yves Heremans, Gunter Leuckx, Nico De Leu, et al. (2016) DIABETOLOGIA. 59(9). p.1834-1837
abstract
The generation of beta(-like) cells to compensate for their absolute or relative shortage in type 1 and type 2 diabetes is an obvious therapeutic strategy. Patients first received grafts of donor islet cells over 25 years ago, but this procedure has not become routine in clinical practice because of a donor cell shortage and (auto) immune problems. Transplantation of differentiated embryonic and induced pluripotent stem cells may overcome some but not all the current limitations. Reprogramming exocrine cells towards functional beta(-like) cells would offer an alternative abundant and autologous source of beta(-like) cells. This review focuses on work by our research group towards achieving such a source of cells. It summarises a presentation given at the 'Can we make a better beta cell?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Amin Ardestani and Kathrin Maedler, DOI: 10.1007/s0012-5016-3892-9, and by Heiko Lickert and colleagues, DOI: 10.1007/s00125-016-3949-9) and a commentary by the Session Chair, Shanta Persaud (DOI: 10.1007/s00125-016-3870-2).
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
Beta cells, Diabetes, Exocrine pancreas, Growth factors, Injury, Macrophages, Proliferation, Regeneration, Review, Transcription factors, (Trans)differentiation, ADULT-MOUSE PANCREAS, EXOCRINE CELLS, DUCT LIGATION, PROLIFERATION, INJURY, DIFFERENTIATION, PROGENITORS, EXPANSION
journal title
DIABETOLOGIA
Diabetologia
volume
59
issue
9
pages
1834 - 1837
Web of Science type
Review
Web of Science id
000380668800005
JCR category
ENDOCRINOLOGY & METABOLISM
JCR impact factor
6.08 (2016)
JCR rank
15/138 (2016)
JCR quartile
1 (2016)
ISSN
0012-186X
1432-0428
DOI
10.1007/s00125-016-3879-6
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8523117
handle
http://hdl.handle.net/1854/LU-8523117
date created
2017-06-12 07:22:28
date last changed
2017-06-28 14:29:32
@article{8523117,
  abstract     = {The generation of beta(-like) cells to compensate for their absolute or relative shortage in type 1 and type 2 diabetes is an obvious therapeutic strategy. Patients first received grafts of donor islet cells over 25 years ago, but this procedure has not become routine in clinical practice because of a donor cell shortage and (auto) immune problems. Transplantation of differentiated embryonic and induced pluripotent stem cells may overcome some but not all the current limitations. Reprogramming exocrine cells towards functional beta(-like) cells would offer an alternative abundant and autologous source of beta(-like) cells. This review focuses on work by our research group towards achieving such a source of cells. It summarises a presentation given at the 'Can we make a better beta cell?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Amin Ardestani and Kathrin Maedler, DOI: 10.1007/s0012-5016-3892-9, and by Heiko Lickert and colleagues, DOI: 10.1007/s00125-016-3949-9) and a commentary by the Session Chair, Shanta Persaud (DOI: 10.1007/s00125-016-3870-2).},
  author       = {De Groef, Sofie and Staels, Willem and Van Gassen, Naomi and Lemper, Marie and Yuchi, Yixing and Sojoodi, Mozhdeh and Bussche, Leen and Heremans, Yves and Leuckx, Gunter and De Leu, Nico and Van de Casteele, Mark and Baeyens, Luc and Heimberg, Harry},
  issn         = {0012-186X},
  journal      = {DIABETOLOGIA},
  keyword      = {Beta cells,Diabetes,Exocrine pancreas,Growth factors,Injury,Macrophages,Proliferation,Regeneration,Review,Transcription factors,(Trans)differentiation,ADULT-MOUSE PANCREAS,EXOCRINE CELLS,DUCT LIGATION,PROLIFERATION,INJURY,DIFFERENTIATION,PROGENITORS,EXPANSION},
  language     = {eng},
  number       = {9},
  pages        = {1834--1837},
  title        = {Sources of beta cells inside the pancreas},
  url          = {http://dx.doi.org/10.1007/s00125-016-3879-6},
  volume       = {59},
  year         = {2016},
}

Chicago
De Groef, Sofie, Willem Staels, Naomi Van Gassen, Marie Lemper, Yixing Yuchi, Mozhdeh Sojoodi, Leen Bussche, et al. 2016. “Sources of Beta Cells Inside the Pancreas.” Diabetologia 59 (9): 1834–1837.
APA
De Groef, S., Staels, W., Van Gassen, N., Lemper, M., Yuchi, Y., Sojoodi, M., Bussche, L., et al. (2016). Sources of beta cells inside the pancreas. DIABETOLOGIA, 59(9), 1834–1837.
Vancouver
1.
De Groef S, Staels W, Van Gassen N, Lemper M, Yuchi Y, Sojoodi M, et al. Sources of beta cells inside the pancreas. DIABETOLOGIA. 2016;59(9):1834–7.
MLA
De Groef, Sofie, Willem Staels, Naomi Van Gassen, et al. “Sources of Beta Cells Inside the Pancreas.” DIABETOLOGIA 59.9 (2016): 1834–1837. Print.