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Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice

Willem Staels UGent, Yves Heremans, Gunter Leuckx, Naomi Van Gassen, Ciro Salinno, Sofie De Groef, Martine Cools UGent, Eli Keshet, Yuval Dor, Harry Heimberg, et al. (2017) DIABETOLOGIA. 60(6). p.1051-1056
abstract
Endothelial-endocrine cell interactions and vascular endothelial growth factor (VEGF)-A signalling are deemed essential for maternal islet vascularisation, glucose control and beta cell expansion during mouse pregnancy. The aim of this study was to assess whether pregnancy-associated beta cell expansion was affected under conditions of islet hypovascularisation. Soluble fms-like tyrosine kinase 1 (sFLT1), a VEGF-A decoy receptor, was conditionally overexpressed in maternal mouse beta cells from 1.5 to 14.5 days post coitum. Islet vascularisation, glycaemic control, beta cell proliferation, individual beta cell size and total beta cell volume were assessed in both pregnant mice and non-pregnant littermates. Conditional overexpression of sFLT1 in beta cells resulted in islet hypovascularisation and glucose intolerance in both pregnant and non-pregnant mice. In contrast to non-pregnant littermates, glucose intolerance in pregnant mice was transient. sFLT1 overexpression did not affect pregnancy-associated changes in beta cell proliferation, individual beta cell size or total beta cell volume. Reduced intra-islet VEGF-A signalling results in maternal islet hypovascularisation and impaired glycaemic control but does not preclude beta cell expansion during mouse pregnancy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Beta cell, FLT1, Islet, Pancreas, Pregnancy, Vascularisation, VEGF, HUMAN GROWTH-HORMONE, ENDOTHELIAL-CELLS, PROLIFERATION, EXPRESSION, MASS, INDUCTION, HYPOXIA
journal title
DIABETOLOGIA
Diabetologia
volume
60
issue
6
pages
1051 - 1056
Web of Science type
Article
Web of Science id
000400995400013
ISSN
0012-186X
DOI
10.1007/s00125-017-4243-1
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8523110
handle
http://hdl.handle.net/1854/LU-8523110
date created
2017-06-12 07:19:21
date last changed
2017-06-28 14:35:19
@article{8523110,
  abstract     = {Endothelial-endocrine cell interactions and vascular endothelial growth factor (VEGF)-A signalling are deemed essential for maternal islet vascularisation, glucose control and beta cell expansion during mouse pregnancy. The aim of this study was to assess whether pregnancy-associated beta cell expansion was affected under conditions of islet hypovascularisation. 
Soluble fms-like tyrosine kinase 1 (sFLT1), a VEGF-A decoy receptor, was conditionally overexpressed in maternal mouse beta cells from 1.5 to 14.5 days post coitum. Islet vascularisation, glycaemic control, beta cell proliferation, individual beta cell size and total beta cell volume were assessed in both pregnant mice and non-pregnant littermates. 
Conditional overexpression of sFLT1 in beta cells resulted in islet hypovascularisation and glucose intolerance in both pregnant and non-pregnant mice. In contrast to non-pregnant littermates, glucose intolerance in pregnant mice was transient. sFLT1 overexpression did not affect pregnancy-associated changes in beta cell proliferation, individual beta cell size or total beta cell volume. 
Reduced intra-islet VEGF-A signalling results in maternal islet hypovascularisation and impaired glycaemic control but does not preclude beta cell expansion during mouse pregnancy.},
  author       = {Staels, Willem and Heremans, Yves and Leuckx, Gunter and Van Gassen, Naomi and Salinno, Ciro and De Groef, Sofie and Cools, Martine and Keshet, Eli and Dor, Yuval and Heimberg, Harry and De Leu, Nico},
  issn         = {0012-186X},
  journal      = {DIABETOLOGIA},
  keyword      = {Beta cell,FLT1,Islet,Pancreas,Pregnancy,Vascularisation,VEGF,HUMAN GROWTH-HORMONE,ENDOTHELIAL-CELLS,PROLIFERATION,EXPRESSION,MASS,INDUCTION,HYPOXIA},
  language     = {eng},
  number       = {6},
  pages        = {1051--1056},
  title        = {Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice},
  url          = {http://dx.doi.org/10.1007/s00125-017-4243-1},
  volume       = {60},
  year         = {2017},
}

Chicago
Staels, Willem, Yves Heremans, Gunter Leuckx, Naomi Van Gassen, Ciro Salinno, Sofie De Groef, Martine Cools, et al. 2017. “Conditional Islet Hypovascularisation Does Not Preclude Beta Cell Expansion During Pregnancy in Mice.” Diabetologia 60 (6): 1051–1056.
APA
Staels, W., Heremans, Y., Leuckx, G., Van Gassen, N., Salinno, C., De Groef, S., Cools, M., et al. (2017). Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice. DIABETOLOGIA, 60(6), 1051–1056.
Vancouver
1.
Staels W, Heremans Y, Leuckx G, Van Gassen N, Salinno C, De Groef S, et al. Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice. DIABETOLOGIA. 2017;60(6):1051–6.
MLA
Staels, Willem, Yves Heremans, Gunter Leuckx, et al. “Conditional Islet Hypovascularisation Does Not Preclude Beta Cell Expansion During Pregnancy in Mice.” DIABETOLOGIA 60.6 (2017): 1051–1056. Print.