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Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice

(2017) DIABETOLOGIA. 60(6). p.1051-1056
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Abstract
Endothelial-endocrine cell interactions and vascular endothelial growth factor (VEGF)-A signalling are deemed essential for maternal islet vascularisation, glucose control and beta cell expansion during mouse pregnancy. The aim of this study was to assess whether pregnancy-associated beta cell expansion was affected under conditions of islet hypovascularisation. Soluble fms-like tyrosine kinase 1 (sFLT1), a VEGF-A decoy receptor, was conditionally overexpressed in maternal mouse beta cells from 1.5 to 14.5 days post coitum. Islet vascularisation, glycaemic control, beta cell proliferation, individual beta cell size and total beta cell volume were assessed in both pregnant mice and non-pregnant littermates. Conditional overexpression of sFLT1 in beta cells resulted in islet hypovascularisation and glucose intolerance in both pregnant and non-pregnant mice. In contrast to non-pregnant littermates, glucose intolerance in pregnant mice was transient. sFLT1 overexpression did not affect pregnancy-associated changes in beta cell proliferation, individual beta cell size or total beta cell volume. Reduced intra-islet VEGF-A signalling results in maternal islet hypovascularisation and impaired glycaemic control but does not preclude beta cell expansion during mouse pregnancy.
Keywords
Beta cell, FLT1, Islet, Pancreas, Pregnancy, Vascularisation, VEGF, HUMAN GROWTH-HORMONE, ENDOTHELIAL-CELLS, PROLIFERATION, EXPRESSION, MASS, INDUCTION, HYPOXIA

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MLA
Staels, Willem et al. “Conditional Islet Hypovascularisation Does Not Preclude Beta Cell Expansion During Pregnancy in Mice.” DIABETOLOGIA 60.6 (2017): 1051–1056. Print.
APA
Staels, W., Heremans, Y., Leuckx, G., Van Gassen, N., Salinno, C., De Groef, S., Cools, M., et al. (2017). Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice. DIABETOLOGIA, 60(6), 1051–1056.
Chicago author-date
Staels, Willem, Yves Heremans, Gunter Leuckx, Naomi Van Gassen, Ciro Salinno, Sofie De Groef, Martine Cools, et al. 2017. “Conditional Islet Hypovascularisation Does Not Preclude Beta Cell Expansion During Pregnancy in Mice.” Diabetologia 60 (6): 1051–1056.
Chicago author-date (all authors)
Staels, Willem, Yves Heremans, Gunter Leuckx, Naomi Van Gassen, Ciro Salinno, Sofie De Groef, Martine Cools, Eli Keshet, Yuval Dor, Harry Heimberg, and Nico De Leu. 2017. “Conditional Islet Hypovascularisation Does Not Preclude Beta Cell Expansion During Pregnancy in Mice.” Diabetologia 60 (6): 1051–1056.
Vancouver
1.
Staels W, Heremans Y, Leuckx G, Van Gassen N, Salinno C, De Groef S, et al. Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice. DIABETOLOGIA. 2017;60(6):1051–6.
IEEE
[1]
W. Staels et al., “Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice,” DIABETOLOGIA, vol. 60, no. 6, pp. 1051–1056, 2017.
@article{8523110,
  abstract     = {Endothelial-endocrine cell interactions and vascular endothelial growth factor (VEGF)-A signalling are deemed essential for maternal islet vascularisation, glucose control and beta cell expansion during mouse pregnancy. The aim of this study was to assess whether pregnancy-associated beta cell expansion was affected under conditions of islet hypovascularisation. 
Soluble fms-like tyrosine kinase 1 (sFLT1), a VEGF-A decoy receptor, was conditionally overexpressed in maternal mouse beta cells from 1.5 to 14.5 days post coitum. Islet vascularisation, glycaemic control, beta cell proliferation, individual beta cell size and total beta cell volume were assessed in both pregnant mice and non-pregnant littermates. 
Conditional overexpression of sFLT1 in beta cells resulted in islet hypovascularisation and glucose intolerance in both pregnant and non-pregnant mice. In contrast to non-pregnant littermates, glucose intolerance in pregnant mice was transient. sFLT1 overexpression did not affect pregnancy-associated changes in beta cell proliferation, individual beta cell size or total beta cell volume. 
Reduced intra-islet VEGF-A signalling results in maternal islet hypovascularisation and impaired glycaemic control but does not preclude beta cell expansion during mouse pregnancy.},
  author       = {Staels, Willem and Heremans, Yves and Leuckx, Gunter and Van Gassen, Naomi and Salinno, Ciro and De Groef, Sofie and Cools, Martine and Keshet, Eli and Dor, Yuval and Heimberg, Harry and De Leu, Nico},
  issn         = {0012-186X},
  journal      = {DIABETOLOGIA},
  keywords     = {Beta cell,FLT1,Islet,Pancreas,Pregnancy,Vascularisation,VEGF,HUMAN GROWTH-HORMONE,ENDOTHELIAL-CELLS,PROLIFERATION,EXPRESSION,MASS,INDUCTION,HYPOXIA},
  language     = {eng},
  number       = {6},
  pages        = {1051--1056},
  title        = {Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice},
  url          = {http://dx.doi.org/10.1007/s00125-017-4243-1},
  volume       = {60},
  year         = {2017},
}

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