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Inflammation and the metabolic syndrome : the tissue-specific functions of NF-κB

Leen Catrysse (UGent) and Geert van Loo (UGent)
(2017) TRENDS IN CELL BIOLOGY. 27(6). p.417-429
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Abstract
Obesity is becoming a major health concern in Western society, and medical conditions associated with obesity are grouped in the metabolic syndrome. Overnutrition activates several proinflammatory signaling pathways, leading to a condition of chronic low-grade inflammation in several metabolic tissues affecting their proper function. Nuclear factor kappa B (NF-kappa B) signaling is a crucial pathway in this process and has been studied extensively in the context of obesity and the metabolic syndrome. Here we give an overview of the molecular mechanisms behind the inflammatory function of NF-kappa B in response to overnutrition and the effect this has on several metabolic tissues.
Keywords
INDUCED INSULIN-RESISTANCE, PANCREATIC BETA-CELLS, DIET-INDUCED OBESITY, ENDOPLASMIC-RETICULUM STRESS, UNFOLDED PROTEIN RESPONSE, FATTY, LIVER-DISEASE, IKK-BETA, ADIPOSE-TISSUE, GLUCOSE-INTOLERANCE, HEPATOCELLULAR-CARCINOMA

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Citation

Please use this url to cite or link to this publication:

Chicago
Catrysse, Leen, and Geert van Loo. 2017. “Inflammation and the Metabolic Syndrome : the Tissue-specific Functions of NF-κB.” Trends in Cell Biology 27 (6): 417–429.
APA
Catrysse, L., & van Loo, G. (2017). Inflammation and the metabolic syndrome : the tissue-specific functions of NF-κB. TRENDS IN CELL BIOLOGY, 27(6), 417–429.
Vancouver
1.
Catrysse L, van Loo G. Inflammation and the metabolic syndrome : the tissue-specific functions of NF-κB. TRENDS IN CELL BIOLOGY. 2017;27(6):417–29.
MLA
Catrysse, Leen, and Geert van Loo. “Inflammation and the Metabolic Syndrome : the Tissue-specific Functions of NF-κB.” TRENDS IN CELL BIOLOGY 27.6 (2017): 417–429. Print.
@article{8522772,
  abstract     = {Obesity is becoming a major health concern in Western society, and medical conditions associated with obesity are grouped in the metabolic syndrome. Overnutrition activates several proinflammatory signaling pathways, leading to a condition of chronic low-grade inflammation in several metabolic tissues affecting their proper function. Nuclear factor kappa B (NF-kappa B) signaling is a crucial pathway in this process and has been studied extensively in the context of obesity and the metabolic syndrome. Here we give an overview of the molecular mechanisms behind the inflammatory function of NF-kappa B in response to overnutrition and the effect this has on several metabolic tissues.},
  author       = {Catrysse, Leen and van Loo, Geert},
  issn         = {0962-8924},
  journal      = {TRENDS IN CELL BIOLOGY},
  keyword      = {INDUCED INSULIN-RESISTANCE,PANCREATIC BETA-CELLS,DIET-INDUCED OBESITY,ENDOPLASMIC-RETICULUM STRESS,UNFOLDED PROTEIN RESPONSE,FATTY,LIVER-DISEASE,IKK-BETA,ADIPOSE-TISSUE,GLUCOSE-INTOLERANCE,HEPATOCELLULAR-CARCINOMA},
  language     = {eng},
  number       = {6},
  pages        = {417--429},
  title        = {Inflammation and the metabolic syndrome : the tissue-specific functions of NF-\ensuremath{\kappa}B},
  url          = {http://dx.doi.org/10.1016/j.tcb.2017.01.006},
  volume       = {27},
  year         = {2017},
}

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