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Patterns, receptors, and signals : regulation of phagosome maturation

Anne-Marie Pauwels UGent, Matthias Trost, Rudi Beyaert UGent and Eik Hoffmann (2017) TRENDS IN IMMUNOLOGY. 38(6). p.407-422
abstract
Recognition of microbial pathogens and dead cells and their phagocytic uptake by specialized immune cells are essential to maintain host homeostasis. Phagosomes undergo fusion and fission events with endosomal and lysosomal compartments, a process called 'phagosome maturation', which leads to the degradation of the phagosomal content. However, many phagocytic cells also act as antigen-presenting cells and must balance degradation and peptide preservation. Emerging evidence indicates that receptor engagement by phagosomal cargo, as well as inflammatory mediators and cellular activation affect many aspects of phagosome maturation. Unsurprisingly, pathogens have developed strategies to hijack this machinery, thereby interfering with host immunity. Here, we highlight progress in this field, summarize findings on the impact of immune signals, and discuss consequences for pathogen elimination.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
ANTIGEN CROSS-PRESENTATION, MYCOBACTERIUM-TUBERCULOSIS SURVIVAL, DENDRITIC CELL MATURATION, TOLL-LIKE RECEPTORS, CLASS-I, AUTOPHAGY, PROTEINS, LATE ENDOSOMES, MOLECULAR CHARACTERIZATION, NONCANONICAL, AUTOPHAGY, ALTERNATIVE ACTIVATION
journal title
TRENDS IN IMMUNOLOGY
Trends Immunol.
volume
38
issue
6
pages
407 - 422
Web of Science type
Review
Web of Science id
000401977800003
ISSN
1471-4906
DOI
10.1016/j.it.2017.03.006
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8522770
handle
http://hdl.handle.net/1854/LU-8522770
date created
2017-06-08 06:19:29
date last changed
2017-06-28 08:38:16
@article{8522770,
  abstract     = {Recognition of microbial pathogens and dead cells and their phagocytic uptake by specialized immune cells are essential to maintain host homeostasis. Phagosomes undergo fusion and fission events with endosomal and lysosomal compartments, a process called 'phagosome maturation', which leads to the degradation of the phagosomal content. However, many phagocytic cells also act as antigen-presenting cells and must balance degradation and peptide preservation. Emerging evidence indicates that receptor engagement by phagosomal cargo, as well as inflammatory mediators and cellular activation affect many aspects of phagosome maturation. Unsurprisingly, pathogens have developed strategies to hijack this machinery, thereby interfering with host immunity. Here, we highlight progress in this field, summarize findings on the impact of immune signals, and discuss consequences for pathogen elimination.},
  author       = {Pauwels, Anne-Marie and Trost, Matthias and Beyaert, Rudi and Hoffmann, Eik},
  issn         = {1471-4906},
  journal      = {TRENDS IN IMMUNOLOGY},
  keyword      = {ANTIGEN CROSS-PRESENTATION,MYCOBACTERIUM-TUBERCULOSIS SURVIVAL,DENDRITIC CELL MATURATION,TOLL-LIKE RECEPTORS,CLASS-I,AUTOPHAGY,PROTEINS,LATE ENDOSOMES,MOLECULAR CHARACTERIZATION,NONCANONICAL,AUTOPHAGY,ALTERNATIVE ACTIVATION},
  language     = {eng},
  number       = {6},
  pages        = {407--422},
  title        = {Patterns, receptors, and signals : regulation of phagosome maturation},
  url          = {http://dx.doi.org/10.1016/j.it.2017.03.006},
  volume       = {38},
  year         = {2017},
}

Chicago
Pauwels, Anne-Marie, Matthias Trost, Rudi Beyaert, and Eik Hoffmann. 2017. “Patterns, Receptors, and Signals : Regulation of Phagosome Maturation.” Trends in Immunology 38 (6): 407–422.
APA
Pauwels, A.-M., Trost, M., Beyaert, R., & Hoffmann, E. (2017). Patterns, receptors, and signals : regulation of phagosome maturation. TRENDS IN IMMUNOLOGY, 38(6), 407–422.
Vancouver
1.
Pauwels A-M, Trost M, Beyaert R, Hoffmann E. Patterns, receptors, and signals : regulation of phagosome maturation. TRENDS IN IMMUNOLOGY. 2017;38(6):407–22.
MLA
Pauwels, Anne-Marie, Matthias Trost, Rudi Beyaert, et al. “Patterns, Receptors, and Signals : Regulation of Phagosome Maturation.” TRENDS IN IMMUNOLOGY 38.6 (2017): 407–422. Print.