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Interventional VSD-closure with the Nit-Occlud® Lê VSD-coil in 110 patients : early and midterm results of the EUREVECO-registry

(2017) PEDIATRIC CARDIOLOGY. 38(2). p.215-227
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Abstract
In August 2010, the Nit-Occlud(A (R)) L (EUREVECO) became available for transcatheter coil occlusion of ventricular septal defects (VSDs). Retrospective European Registry for VSD Closure using the Nit-Occlud(A (R)) L-VSD-Coil; analysis of the feasibility, results, safety and follow-up of VSD-closure over a 3-year period in 18 European centers. In 102 of 111 patients (female 66), successful VSD closure was performed (mean age 8.2 years, mean weight 28.82 kg), 81 perimembranous VSDs (48 with aneurysm), 30 muscular VSDs, mean procedure time was 121.1 min, and mean fluoroscopy time was 26.3 min. Short- and midterm term follow-up was possible in 100/102 patients, there was 1 embolization and 1 explantation after 24 months. Immediate complete closure occurred in 49 of 101 patients (48.5%), trivial residual shunt was present in 51 (50.0%), closure rate was 95% after 6 months and 97% after 1 year. Out of the 102 patients, there were 2 severe complications (1.8%) (1 severe hemolysis, 1 embolization) and 8 moderate/transient (=7.2%) including 1 transient AV block. During a mean follow-up period of 31.3 months (range 24-48) and a total follow-up time of 224.75 patient years, no further problems occurred. VSD closure with the Nit-Occlud(A (R)) L VSD coil is feasible and safe with a minimal risk of severe side effects. The long-term effects and safety require further clinical follow-up studies.
Keywords
Interventional VSD closure, Perimembranous VSD, Muscular VSD, Congenital heart defects, Nit-Occlud (R), Le-VSD-Coil, EUREVECO, VENTRICULAR SEPTAL-DEFECTS, TRANSCATHETER DEVICE CLOSURE, FOLLOW-UP, SURGICAL CLOSURE, AMPLATZER DEVICE, OCCLUDER, CHILDREN, TRIAL, EXPERIENCE, SAFETY

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MLA
Haas, Nikolaus A et al. “Interventional VSD-closure with the Nit-Occlud® Lê VSD-coil in 110 Patients : Early and Midterm Results of the EUREVECO-registry.” PEDIATRIC CARDIOLOGY 38.2 (2017): 215–227. Print.
APA
Haas, N. A., Kock, L., Bertram, H., Boekenkamp, R., De Wolf, D., Ditkivskyy, I., Freund, M. W., et al. (2017). Interventional VSD-closure with the Nit-Occlud® Lê VSD-coil in 110 patients : early and midterm results of the EUREVECO-registry. PEDIATRIC CARDIOLOGY, 38(2), 215–227.
Chicago author-date
Haas, Nikolaus A, Laura Kock, Harald Bertram, Regina Boekenkamp, Daniël De Wolf, Igor Ditkivskyy, Matthias W Freund, et al. 2017. “Interventional VSD-closure with the Nit-Occlud® Lê VSD-coil in 110 Patients : Early and Midterm Results of the EUREVECO-registry.” Pediatric Cardiology 38 (2): 215–227.
Chicago author-date (all authors)
Haas, Nikolaus A, Laura Kock, Harald Bertram, Regina Boekenkamp, Daniël De Wolf, Igor Ditkivskyy, Matthias W Freund, Marc Gewillig, Christoph M Happel, Ulrike Herberg, Edvard Karthasyan, Rainer Kozlik-Feldmann, Oliver Kretschmar, Yulia Kuzmenko, Ornella Milanesi, Goetz Mueller, Giacomo Pongiglione, Stephan Schubert, Gleb Tarusinov, and Christoph Kampmann. 2017. “Interventional VSD-closure with the Nit-Occlud® Lê VSD-coil in 110 Patients : Early and Midterm Results of the EUREVECO-registry.” Pediatric Cardiology 38 (2): 215–227.
Vancouver
1.
Haas NA, Kock L, Bertram H, Boekenkamp R, De Wolf D, Ditkivskyy I, et al. Interventional VSD-closure with the Nit-Occlud® Lê VSD-coil in 110 patients : early and midterm results of the EUREVECO-registry. PEDIATRIC CARDIOLOGY. 2017;38(2):215–27.
IEEE
[1]
N. A. Haas et al., “Interventional VSD-closure with the Nit-Occlud® Lê VSD-coil in 110 patients : early and midterm results of the EUREVECO-registry,” PEDIATRIC CARDIOLOGY, vol. 38, no. 2, pp. 215–227, 2017.
@article{8522404,
  abstract     = {In August 2010, the Nit-Occlud(A (R)) L (EUREVECO) became available for transcatheter coil occlusion of ventricular septal defects (VSDs). Retrospective European Registry for VSD Closure using the Nit-Occlud(A (R)) L-VSD-Coil; analysis of the feasibility, results, safety and follow-up of VSD-closure over a 3-year period in 18 European centers. In 102 of 111 patients (female 66), successful VSD closure was performed (mean age 8.2 years, mean weight 28.82 kg), 81 perimembranous VSDs (48 with aneurysm), 30 muscular VSDs, mean procedure time was 121.1 min, and mean fluoroscopy time was 26.3 min. Short- and midterm term follow-up was possible in 100/102 patients, there was 1 embolization and 1 explantation after 24 months. Immediate complete closure occurred in 49 of 101 patients (48.5%), trivial residual shunt was present in 51 (50.0%), closure rate was 95% after 6 months and 97% after 1 year. Out of the 102 patients, there were 2 severe complications (1.8%) (1 severe hemolysis, 1 embolization) and 8 moderate/transient (=7.2%) including 1 transient AV block. During a mean follow-up period of 31.3 months (range 24-48) and a total follow-up time of 224.75 patient years, no further problems occurred. VSD closure with the Nit-Occlud(A (R)) L VSD coil is feasible and safe with a minimal risk of severe side effects. The long-term effects and safety require further clinical follow-up studies.},
  author       = {Haas, Nikolaus A and Kock, Laura and Bertram, Harald and Boekenkamp, Regina and De Wolf, Daniël and Ditkivskyy, Igor and Freund, Matthias W and Gewillig, Marc and Happel, Christoph M and Herberg, Ulrike and Karthasyan, Edvard and Kozlik-Feldmann, Rainer and Kretschmar, Oliver and Kuzmenko, Yulia and Milanesi, Ornella and Mueller, Goetz and Pongiglione, Giacomo and Schubert, Stephan and Tarusinov, Gleb and Kampmann, Christoph},
  issn         = {0172-0643},
  journal      = {PEDIATRIC CARDIOLOGY},
  keywords     = {Interventional VSD closure,Perimembranous VSD,Muscular VSD,Congenital heart defects,Nit-Occlud (R),Le-VSD-Coil,EUREVECO,VENTRICULAR SEPTAL-DEFECTS,TRANSCATHETER DEVICE CLOSURE,FOLLOW-UP,SURGICAL CLOSURE,AMPLATZER DEVICE,OCCLUDER,CHILDREN,TRIAL,EXPERIENCE,SAFETY},
  language     = {eng},
  number       = {2},
  pages        = {215--227},
  title        = {Interventional VSD-closure with the Nit-Occlud® Lê VSD-coil in 110 patients : early and midterm results of the EUREVECO-registry},
  url          = {http://dx.doi.org/10.1007/s00246-016-1502-8},
  volume       = {38},
  year         = {2017},
}

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