Advanced search
1 file | 1.80 MB Add to list

Poly-ubiquitination in TNFR1-mediated necroptosis

(2016) CELLULAR AND MOLECULAR LIFE SCIENCES. 73(11-12). p.2165-2176
Author
Organization
Abstract
Tumor necrosis factor (TNF) is a master pro-inflammatory cytokine, and inappropriate TNF signaling is implicated in the pathology of many inflammatory diseases. Ligation of TNF to its receptor TNFR1 induces the transient formation of a primary membrane-bound signaling complex, known as complex I, that drives expression of pro-survival genes. Defective complex I activation results in induction of cell death, in the form of apoptosis or necroptosis. This switch occurs via internalization of complex I components and assembly and activation of secondary cytoplasmic death complexes, respectively known as complex II and necrosome. In this review, we discuss the crucial regulatory functions of ubiquitination-a post-translational protein modification consisting of the covalent attachment of ubiquitin, and multiples thereof, to target proteins-to the various steps of TNFR1 signaling leading to necroptosis.
Keywords
NF-KAPPA-B, TUMOR-NECROSIS-FACTOR, CHRONIC PROLIFERATIVE DERMATITIS, SIGNAL-INDUCED PHOSPHORYLATION, RECEPTOR INTERACTING PROTEIN, LINEAR, POLYUBIQUITIN CHAINS, TNF-INDUCED NECROSIS, CELL-DEATH, DEUBIQUITINATING, ENZYME, PROGRAMMED NECROSIS, Ubiquitination, Necroptosis, TNFR1, RIPK1, c IAP1/2, LUBAC, A20, CYLD

Downloads

  • 2626 16Dondelinger.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 1.80 MB

Citation

Please use this url to cite or link to this publication:

MLA
Dondelinger, Yves et al. “Poly-ubiquitination in TNFR1-mediated Necroptosis.” CELLULAR AND MOLECULAR LIFE SCIENCES 73.11-12 (2016): 2165–2176. Print.
APA
Dondelinger, Y., Darding, M., Bertrand, M., & Walczak, H. (2016). Poly-ubiquitination in TNFR1-mediated necroptosis. CELLULAR AND MOLECULAR LIFE SCIENCES, 73(11-12), 2165–2176.
Chicago author-date
Dondelinger, Yves, Maurice Darding, Mathieu Bertrand, and Henning Walczak. 2016. “Poly-ubiquitination in TNFR1-mediated Necroptosis.” Cellular and Molecular Life Sciences 73 (11-12): 2165–2176.
Chicago author-date (all authors)
Dondelinger, Yves, Maurice Darding, Mathieu Bertrand, and Henning Walczak. 2016. “Poly-ubiquitination in TNFR1-mediated Necroptosis.” Cellular and Molecular Life Sciences 73 (11-12): 2165–2176.
Vancouver
1.
Dondelinger Y, Darding M, Bertrand M, Walczak H. Poly-ubiquitination in TNFR1-mediated necroptosis. CELLULAR AND MOLECULAR LIFE SCIENCES. 2016;73(11-12):2165–76.
IEEE
[1]
Y. Dondelinger, M. Darding, M. Bertrand, and H. Walczak, “Poly-ubiquitination in TNFR1-mediated necroptosis,” CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 73, no. 11–12, pp. 2165–2176, 2016.
@article{8522266,
  abstract     = {Tumor necrosis factor (TNF) is a master pro-inflammatory cytokine, and inappropriate TNF signaling is implicated in the pathology of many inflammatory diseases. Ligation of TNF to its receptor TNFR1 induces the transient formation of a primary membrane-bound signaling complex, known as complex I, that drives expression of pro-survival genes. Defective complex I activation results in induction of cell death, in the form of apoptosis or necroptosis. This switch occurs via internalization of complex I components and assembly and activation of secondary cytoplasmic death complexes, respectively known as complex II and necrosome. In this review, we discuss the crucial regulatory functions of ubiquitination-a post-translational protein modification consisting of the covalent attachment of ubiquitin, and multiples thereof, to target proteins-to the various steps of TNFR1 signaling leading to necroptosis.},
  author       = {Dondelinger, Yves and Darding, Maurice and Bertrand, Mathieu and Walczak, Henning},
  issn         = {1420-682X},
  journal      = {CELLULAR AND MOLECULAR LIFE SCIENCES},
  keywords     = {NF-KAPPA-B,TUMOR-NECROSIS-FACTOR,CHRONIC PROLIFERATIVE DERMATITIS,SIGNAL-INDUCED PHOSPHORYLATION,RECEPTOR INTERACTING PROTEIN,LINEAR,POLYUBIQUITIN CHAINS,TNF-INDUCED NECROSIS,CELL-DEATH,DEUBIQUITINATING,ENZYME,PROGRAMMED NECROSIS,Ubiquitination,Necroptosis,TNFR1,RIPK1,c IAP1/2,LUBAC,A20,CYLD},
  language     = {eng},
  number       = {11-12},
  pages        = {2165--2176},
  title        = {Poly-ubiquitination in TNFR1-mediated necroptosis},
  url          = {http://dx.doi.org/10.1007/s00018-016-2191-4},
  volume       = {73},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: