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Immunogenic apoptotic cell death and anticancer immunity

Peter Vandenabeele (UGent), Katrien Vandecasteele (UGent), Claus Bachert (UGent), Olga Krysko (UGent) and Dmitri Krysko (UGent)
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Abstract
For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells do not trigger an immune response but rather have anti-inflammatory properties. However, accumulating experimental data indicate that certain anticancer therapies can induce an immunogenic form of apoptosis associated with the emission of damage-associated molecular patterns (DAMPs), which function as adjuvants to activate host antitumor immune responses. In this review, we will first discuss recent advances and the significance of danger signaling pathways involved in the emission of DAMPs, including calreticulin, ATP, and HMGB1. We will also emphasize that switching on a particular signaling pathway depends on the immunogenic cell death stimulus. Further, we address the role of ER stress in danger signaling and the classification of immunogenic cell death inducers in relation to how ER stress is triggered. In the final part, we discuss the role of radiotherapy-induced immunogenic apoptosis and the relationship of its immunogenicity to the fraction dose and concomitant chemotherapy.
Keywords
HUMAN-TUMOR-CELLS, CALRETICULIN EXPOSURE, NECROTIC CELLS, CHEMOTHERAPEUTIC-AGENTS, CANCER-CELLS, LUNG-CANCER, ENDOPLASMIC-RETICULUM, METASTATIC MELANOMA, CYTOKINE PRODUCTION, ANTITUMOR IMMUNITY, ATP, HMGB1, Calreticulin, DAMPs, Cancer, Radiotherapy, ER stress, Tumors, Chemotherapeutics

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Chicago
Vandenabeele, Peter, Katrien Vandecasteele, Claus Bachert, Olga Krysko, and Dmitri Krysko. 2016. “Immunogenic Apoptotic Cell Death and Anticancer Immunity.” Ed. Christopher D Gregory. Advances in Experimental Medicine and Biology 930: 133–149.
APA
Vandenabeele, P., Vandecasteele, K., Bachert, C., Krysko, O., & Krysko, D. (2016). Immunogenic apoptotic cell death and anticancer immunity. (C. D. Gregory, Ed.)Advances in Experimental Medicine and Biology, 930, 133–149.
Vancouver
1.
Vandenabeele P, Vandecasteele K, Bachert C, Krysko O, Krysko D. Immunogenic apoptotic cell death and anticancer immunity. Gregory CD, editor. Advances in Experimental Medicine and Biology. Berlin: Springer; 2016;930:133–49.
MLA
Vandenabeele, Peter, Katrien Vandecasteele, Claus Bachert, et al. “Immunogenic Apoptotic Cell Death and Anticancer Immunity.” Ed. Christopher D Gregory. Advances in Experimental Medicine and Biology 930 (2016): 133–149. Print.
@article{8522205,
  abstract     = {For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells do not trigger an immune response but rather have anti-inflammatory properties. However, accumulating experimental data indicate that certain anticancer therapies can induce an immunogenic form of apoptosis associated with the emission of damage-associated molecular patterns (DAMPs), which function as adjuvants to activate host antitumor immune responses. In this review, we will first discuss recent advances and the significance of danger signaling pathways involved in the emission of DAMPs, including calreticulin, ATP, and HMGB1. We will also emphasize that switching on a particular signaling pathway depends on the immunogenic cell death stimulus. Further, we address the role of ER stress in danger signaling and the classification of immunogenic cell death inducers in relation to how ER stress is triggered. In the final part, we discuss the role of radiotherapy-induced immunogenic apoptosis and the relationship of its immunogenicity to the fraction dose and concomitant chemotherapy.},
  author       = {Vandenabeele, Peter and Vandecasteele, Katrien and Bachert, Claus and Krysko, Olga and Krysko, Dmitri},
  editor       = {Gregory, Christopher D},
  isbn         = {9783319394046},
  issn         = {0065-2598},
  journal      = {Advances in Experimental Medicine and Biology},
  keyword      = {HUMAN-TUMOR-CELLS,CALRETICULIN EXPOSURE,NECROTIC CELLS,CHEMOTHERAPEUTIC-AGENTS,CANCER-CELLS,LUNG-CANCER,ENDOPLASMIC-RETICULUM,METASTATIC MELANOMA,CYTOKINE PRODUCTION,ANTITUMOR IMMUNITY,ATP,HMGB1,Calreticulin,DAMPs,Cancer,Radiotherapy,ER stress,Tumors,Chemotherapeutics},
  language     = {eng},
  pages        = {133--149},
  publisher    = {Springer},
  title        = {Immunogenic apoptotic cell death and anticancer immunity},
  url          = {http://dx.doi.org/10.1007/978-3-319-39406-0\_6},
  volume       = {930},
  year         = {2016},
}

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