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Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory

Laura Walrave, Mathieu Vinken, Giulia Albertini, Dimitri De Bundel, Luc Leybaert UGent and Ilse J. Smolders (2016) FRONTIERS IN CELLULAR NEUROSCIENCE. 10.
abstract
Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ones, for example by passive diffusion via connexin hemichannels (HCs). We here investigated whether interfering with connexin43 (Cx43) HCs influenced hippocampal spatial memory. We made use of the peptide Gap19 that blocks HCs but not gap junction channels and is specific for Cx43. To this end, we microinfused transactivator of transcription linked Gap19 (TAT-Gap19) into the brain ventricle of male NMRI mice and assessed spatial memory in a Y maze. We found that the in vivo blockade of Cx43 HCs did not affect the locomotor activity or spatial working memory in a spontaneous alternation Y maze task. Cx43 blockade did however significantly impair the spatial short-term memory in a delayed spontaneous alternation Y maze task. These results indicate that Cx43 HCs play a role in spatial short-term memory.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SCOPOLAMINE-INDUCED AMNESIA, GAP-JUNCTION CHANNELS, PREFRONTAL CORTEX, ASTROCYTES, MICE, HIPPOCAMPUS, RELEASE, RATS, GLIOTRANSMITTERS, RECOGNITION, connexin43, Y maze, TAT-Gap19, working memory, short-term memory
journal title
FRONTIERS IN CELLULAR NEUROSCIENCE
Front. Cell. Neurosci.
volume
10
article number
288
pages
10 pages
Web of Science type
Article
Web of Science id
000390161400002
JCR category
NEUROSCIENCES
JCR impact factor
4.555 (2016)
JCR rank
55/258 (2016)
JCR quartile
1 (2016)
ISSN
1662-5102
DOI
10.3389/fncel.2016.00288
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
8521850
handle
http://hdl.handle.net/1854/LU-8521850
date created
2017-05-31 13:48:52
date last changed
2017-06-19 09:29:03
@article{8521850,
  abstract     = {Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ones, for example by passive diffusion via connexin hemichannels (HCs). We here investigated whether interfering with connexin43 (Cx43) HCs influenced hippocampal spatial memory. We made use of the peptide Gap19 that blocks HCs but not gap junction channels and is specific for Cx43. To this end, we microinfused transactivator of transcription linked Gap19 (TAT-Gap19) into the brain ventricle of male NMRI mice and assessed spatial memory in a Y maze. We found that the in vivo blockade of Cx43 HCs did not affect the locomotor activity or spatial working memory in a spontaneous alternation Y maze task. Cx43 blockade did however significantly impair the spatial short-term memory in a delayed spontaneous alternation Y maze task. These results indicate that Cx43 HCs play a role in spatial short-term memory.},
  articleno    = {288},
  author       = {Walrave, Laura and Vinken, Mathieu and Albertini, Giulia and De Bundel, Dimitri and Leybaert, Luc and Smolders, Ilse J.},
  issn         = {1662-5102},
  journal      = {FRONTIERS IN CELLULAR NEUROSCIENCE},
  keyword      = {SCOPOLAMINE-INDUCED AMNESIA,GAP-JUNCTION CHANNELS,PREFRONTAL CORTEX,ASTROCYTES,MICE,HIPPOCAMPUS,RELEASE,RATS,GLIOTRANSMITTERS,RECOGNITION,connexin43,Y maze,TAT-Gap19,working memory,short-term memory},
  language     = {eng},
  pages        = {10},
  title        = {Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory},
  url          = {http://dx.doi.org/10.3389/fncel.2016.00288},
  volume       = {10},
  year         = {2016},
}

Chicago
Walrave, Laura, Mathieu Vinken, Giulia Albertini, Dimitri De Bundel, Luc Leybaert, and Ilse J. Smolders. 2016. “Inhibition of Connexin43 Hemichannels Impairs Spatial Short-term Memory Without Affecting Spatial Working Memory.” Frontiers in Cellular Neuroscience 10.
APA
Walrave, L., Vinken, M., Albertini, G., De Bundel, D., Leybaert, L., & Smolders, I. J. (2016). Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory. FRONTIERS IN CELLULAR NEUROSCIENCE, 10.
Vancouver
1.
Walrave L, Vinken M, Albertini G, De Bundel D, Leybaert L, Smolders IJ. Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory. FRONTIERS IN CELLULAR NEUROSCIENCE. 2016;10.
MLA
Walrave, Laura, Mathieu Vinken, Giulia Albertini, et al. “Inhibition of Connexin43 Hemichannels Impairs Spatial Short-term Memory Without Affecting Spatial Working Memory.” FRONTIERS IN CELLULAR NEUROSCIENCE 10 (2016): n. pag. Print.