Ghent University Academic Bibliography

Advanced

Generalized hyperalgesia in children and adults diagnosed with hypermobility syndrome and Ehlers-Danlos syndrome Hypermobility type : a discriminative analysis

MC Scheper, V Pacey, Lies Rombaut UGent, RD Adams, L Tofts, Patrick Calders UGent, LL Nicholson and RHH Engelbert (2016) ARTHRITIS CARE & RESEARCH. 69(3). p.421-429
abstract
Objective. Lowered pressure-pain thresholds have been demonstrated in adults with Ehlers-Danlos syndrome hypermobility type (EDS-HT), but whether these findings are also present in children is unclear. Therefore, the objectives of the study were to determine whether generalized hyperalgesia is present in children with hypermobility syndrome (HMS)/EDS-HT, explore potential differences in pressure-pain thresholds between children and adults with HMS/EDS-HT, and determine the discriminative value of generalized hyperalgesia. Methods. Patients were classified in 1 of 3 groups: HMS/EDS-HT, hypermobile (Beighton score >= 4 of 9), and healthy controls. Descriptive data of age, sex, body mass index, Beighton score, skin laxity, and medication usage were collected. Generalized hyperalgesia was quantified by the average pressure-pain thresholds collected from 12 locations. Confounders collected were pain locations/intensity, fatigue, and psychological distress. Comparisons between children with HMS/EDS-HT and normative values, between children and adults with HMS/EDS-HT, and corrected confounders were analyzed with multivariate analysis of covariance. The discriminative value of generalized hyperalgesia employed to differentiate between HMS/EDS-HT, hypermobility, and controls was quantified with logistic regression. Results. Significantly lower pressure-pain thresholds were found in children with HMS/EDS-HT compared to normative values (range -22.0% to -59.0%; P <= 0.05). When applying a threshold of 30.8 N/cm(2) for males and 29.0 N/cm(2) for females, the presence of generalized hyperalgesia discriminated between individuals with HMS/EDS-HT, hypermobility, and healthy controls (odds ratio 6.0). Conclusion. Children and adults with HMS/EDS-HT are characterized by hypermobility, chronic pain, and generalized hyperalgesia. The presence of generalized hyperalgesia may indicate involvement of the central nervous system in the development of chronic pain.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
QUALITY-OF-LIFE, JOINT HYPERMOBILITY, CHRONIC PAIN, MUSCULOSKELETAL PAIN, PRESSURE PAIN, RISK-FACTORS, SYNDROME BJHS, RELIABILITY, VALIDITY, SENSITIVITY
journal title
ARTHRITIS CARE & RESEARCH
Arthritis Care Res.
volume
69
issue
3
pages
421 - 429
Web of Science type
Article
Web of Science id
000394988800013
JCR category
RHEUMATOLOGY
JCR impact factor
3.319 (2016)
JCR rank
12/30 (2016)
JCR quartile
2 (2016)
ISSN
2151-464X
DOI
10.1002/acr.22998
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8521183
handle
http://hdl.handle.net/1854/LU-8521183
date created
2017-05-23 09:16:48
date last changed
2017-06-19 08:07:57
@article{8521183,
  abstract     = {Objective. Lowered pressure-pain thresholds have been demonstrated in adults with Ehlers-Danlos syndrome hypermobility type (EDS-HT), but whether these findings are also present in children is unclear. Therefore, the objectives of the study were to determine whether generalized hyperalgesia is present in children with hypermobility syndrome (HMS)/EDS-HT, explore potential differences in pressure-pain thresholds between children and adults with HMS/EDS-HT, and determine the discriminative value of generalized hyperalgesia. 
Methods. Patients were classified in 1 of 3 groups: HMS/EDS-HT, hypermobile (Beighton score {\textrangle}= 4 of 9), and healthy controls. Descriptive data of age, sex, body mass index, Beighton score, skin laxity, and medication usage were collected. Generalized hyperalgesia was quantified by the average pressure-pain thresholds collected from 12 locations. Confounders collected were pain locations/intensity, fatigue, and psychological distress. Comparisons between children with HMS/EDS-HT and normative values, between children and adults with HMS/EDS-HT, and corrected confounders were analyzed with multivariate analysis of covariance. The discriminative value of generalized hyperalgesia employed to differentiate between HMS/EDS-HT, hypermobility, and controls was quantified with logistic regression. 
Results. Significantly lower pressure-pain thresholds were found in children with HMS/EDS-HT compared to normative values (range -22.0\% to -59.0\%; P {\textlangle}= 0.05). When applying a threshold of 30.8 N/cm(2) for males and 29.0 N/cm(2) for females, the presence of generalized hyperalgesia discriminated between individuals with HMS/EDS-HT, hypermobility, and healthy controls (odds ratio 6.0). 
Conclusion. Children and adults with HMS/EDS-HT are characterized by hypermobility, chronic pain, and generalized hyperalgesia. The presence of generalized hyperalgesia may indicate involvement of the central nervous system in the development of chronic pain.},
  author       = {Scheper, MC and Pacey, V and Rombaut, Lies and Adams, RD and Tofts, L and Calders, Patrick and Nicholson, LL and Engelbert, RHH},
  issn         = {2151-464X},
  journal      = {ARTHRITIS CARE \& RESEARCH},
  keyword      = {QUALITY-OF-LIFE,JOINT HYPERMOBILITY,CHRONIC PAIN,MUSCULOSKELETAL PAIN,PRESSURE PAIN,RISK-FACTORS,SYNDROME BJHS,RELIABILITY,VALIDITY,SENSITIVITY},
  language     = {eng},
  number       = {3},
  pages        = {421--429},
  title        = {Generalized hyperalgesia in children and adults diagnosed with hypermobility syndrome and Ehlers-Danlos syndrome Hypermobility type : a discriminative analysis},
  url          = {http://dx.doi.org/10.1002/acr.22998},
  volume       = {69},
  year         = {2016},
}

Chicago
Scheper, MC, V Pacey, Lies Rombaut, RD Adams, L Tofts, Patrick Calders, LL Nicholson, and RHH Engelbert. 2016. “Generalized Hyperalgesia in Children and Adults Diagnosed with Hypermobility Syndrome and Ehlers-Danlos Syndrome Hypermobility Type : a Discriminative Analysis.” Arthritis Care & Research 69 (3): 421–429.
APA
Scheper, MC, Pacey, V., Rombaut, L., Adams, R., Tofts, L., Calders, P., Nicholson, L., et al. (2016). Generalized hyperalgesia in children and adults diagnosed with hypermobility syndrome and Ehlers-Danlos syndrome Hypermobility type : a discriminative analysis. ARTHRITIS CARE & RESEARCH, 69(3), 421–429.
Vancouver
1.
Scheper M, Pacey V, Rombaut L, Adams R, Tofts L, Calders P, et al. Generalized hyperalgesia in children and adults diagnosed with hypermobility syndrome and Ehlers-Danlos syndrome Hypermobility type : a discriminative analysis. ARTHRITIS CARE & RESEARCH. 2016;69(3):421–9.
MLA
Scheper, MC, V Pacey, Lies Rombaut, et al. “Generalized Hyperalgesia in Children and Adults Diagnosed with Hypermobility Syndrome and Ehlers-Danlos Syndrome Hypermobility Type : a Discriminative Analysis.” ARTHRITIS CARE & RESEARCH 69.3 (2016): 421–429. Print.