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Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms

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Abstract
The oral use of antimicrobial agents embedded in toothpastes and mouth rinses results in an oral microbial massacre with high amounts of dead bacteria in close proximity to few surviving bacteria. It was hypothesized that this provides the surviving pathogenic bacteria a large amount of dead microbial biomass as a nutritional source for growth (necrotrophy). This study demonstrated the necrotrophic growth of periodontal pathogens in the presence of different dead oral species. In addition, the presence of dead bacteria resulted in an outgrowth of several periodontal pathogens in complex multispecies biofilms. Additionally, upon contact with dead oral bacteria, virulence genes of P. intermedia and P. gingivalis were up-regulated (necrovirulence). This resulted in a more pronounced epithelial cytotoxicity (necrotoxicity). These findings indicate that presence of dead bacteria induce necrotrophy, necrovirulence and necrotoxicity in several oral pathogens.
Keywords
GINGIVAL EPITHELIAL-CELLS, PORPHYROMONAS-GINGIVALIS, LEGIONELLA-PNEUMOPHILA, PREVOTELLA-INTERMEDIA, SPORULATING BACTERIA, CHLORHEXIDINE, CANNIBALISM, GENE, INFECTIONS, EXPRESSION

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Citation

Please use this url to cite or link to this publication:

MLA
Rodriguez Herrero, Esteban et al. “Necrotrophic Growth of Periodontopathogens Is a Novel Virulence Factor in Oral Biofilms.” SCIENTIFIC REPORTS 7 (2017): n. pag. Print.
APA
Rodriguez Herrero, E., Boon, N., Pauwels, M., Bernaerts, K., Slomka, V., Quirynen, M., & Teughels, W. (2017). Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms. SCIENTIFIC REPORTS, 7.
Chicago author-date
Rodriguez Herrero, Esteban, Nico Boon, Martine Pauwels, Kristel Bernaerts, Vera Slomka, Marc Quirynen, and Wim Teughels. 2017. “Necrotrophic Growth of Periodontopathogens Is a Novel Virulence Factor in Oral Biofilms.” Scientific Reports 7.
Chicago author-date (all authors)
Rodriguez Herrero, Esteban, Nico Boon, Martine Pauwels, Kristel Bernaerts, Vera Slomka, Marc Quirynen, and Wim Teughels. 2017. “Necrotrophic Growth of Periodontopathogens Is a Novel Virulence Factor in Oral Biofilms.” Scientific Reports 7.
Vancouver
1.
Rodriguez Herrero E, Boon N, Pauwels M, Bernaerts K, Slomka V, Quirynen M, et al. Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms. SCIENTIFIC REPORTS. 2017;7.
IEEE
[1]
E. Rodriguez Herrero et al., “Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms,” SCIENTIFIC REPORTS, vol. 7, 2017.
@article{8521077,
  abstract     = {The oral use of antimicrobial agents embedded in toothpastes and mouth rinses results in an oral microbial massacre with high amounts of dead bacteria in close proximity to few surviving bacteria. It was hypothesized that this provides the surviving pathogenic bacteria a large amount of dead microbial biomass as a nutritional source for growth (necrotrophy). This study demonstrated the necrotrophic growth of periodontal pathogens in the presence of different dead oral species. In addition, the presence of dead bacteria resulted in an outgrowth of several periodontal pathogens in complex multispecies biofilms. Additionally, upon contact with dead oral bacteria, virulence genes of P. intermedia and P. gingivalis were up-regulated (necrovirulence). This resulted in a more pronounced epithelial cytotoxicity (necrotoxicity). These findings indicate that presence of dead bacteria induce necrotrophy, necrovirulence and necrotoxicity in several oral pathogens.},
  articleno    = {1107},
  author       = {Rodriguez Herrero, Esteban and Boon, Nico and Pauwels, Martine and Bernaerts, Kristel and Slomka, Vera and Quirynen, Marc and Teughels, Wim},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keywords     = {GINGIVAL EPITHELIAL-CELLS,PORPHYROMONAS-GINGIVALIS,LEGIONELLA-PNEUMOPHILA,PREVOTELLA-INTERMEDIA,SPORULATING BACTERIA,CHLORHEXIDINE,CANNIBALISM,GENE,INFECTIONS,EXPRESSION},
  language     = {eng},
  pages        = {10},
  title        = {Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms},
  url          = {http://dx.doi.org/10.1038/s41598-017-01239-9},
  volume       = {7},
  year         = {2017},
}

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