Advanced search
1 file | 944.06 KB

T-ALL and thymocytes : a message of noncoding RNAs

Annelynn Wallaert (UGent) , Kaat Durinck (UGent) , Tom Taghon (UGent) , Pieter Van Vlierberghe (UGent) and Franki Speleman (UGent)
Author
Organization
Abstract
In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell acute lymphoblastic leukemia, which is a malignant blood disorder arising from oncogenic events during normal T cell development in the thymus. By studying the transcriptomic profile of protein-coding genes, several oncogenic events leading to T cell acute lymphoblastic leukemia (T-ALL) could be identified. In recent years, it became apparent that several of these oncogenes function via microRNAs and long noncoding RNAs. In this review, we give a detailed overview of the studies that describe the noncoding RNAome in T-ALL oncogenesis and normal T cell development.
Keywords
T-ALL, Thymocytes, LncRNA, MicroRNA, ACUTE LYMPHOBLASTIC-LEUKEMIA, COMPETING ENDOGENOUS RNA, TUMOR-SUPPRESSOR, CELL DEVELOPMENT, GENE-EXPRESSION, MICRORNA BIOGENESIS, GLUCOCORTICOID-RECEPTOR, MICROPROCESSOR COMPLEX, SIGNATURES DEFINE, MIRNA EXPRESSION

Downloads

  • JHO Wallaert.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 944.06 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Wallaert, Annelynn, Kaat Durinck, Tom Taghon, Pieter Van Vlierberghe, and Franki Speleman. 2017. “T-ALL and Thymocytes : a Message of Noncoding RNAs.” Journal of Hematology & Oncology 10.
APA
Wallaert, A., Durinck, K., Taghon, T., Van Vlierberghe, P., & Speleman, F. (2017). T-ALL and thymocytes : a message of noncoding RNAs. JOURNAL OF HEMATOLOGY & ONCOLOGY, 10.
Vancouver
1.
Wallaert A, Durinck K, Taghon T, Van Vlierberghe P, Speleman F. T-ALL and thymocytes : a message of noncoding RNAs. JOURNAL OF HEMATOLOGY & ONCOLOGY. 2017;10.
MLA
Wallaert, Annelynn, Kaat Durinck, Tom Taghon, et al. “T-ALL and Thymocytes : a Message of Noncoding RNAs.” JOURNAL OF HEMATOLOGY & ONCOLOGY 10 (2017): n. pag. Print.
@article{8521064,
  abstract     = {In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell acute lymphoblastic leukemia, which is a malignant blood disorder arising from oncogenic events during normal T cell development in the thymus. By studying the transcriptomic profile of protein-coding genes, several oncogenic events leading to T cell acute lymphoblastic leukemia (T-ALL) could be identified. In recent years, it became apparent that several of these oncogenes function via microRNAs and long noncoding RNAs. In this review, we give a detailed overview of the studies that describe the noncoding RNAome in T-ALL oncogenesis and normal T cell development.},
  articleno    = {66},
  author       = {Wallaert, Annelynn and Durinck, Kaat and Taghon, Tom and Van Vlierberghe, Pieter and Speleman, Franki},
  issn         = {1756-8722},
  journal      = {JOURNAL OF HEMATOLOGY & ONCOLOGY},
  keywords     = {T-ALL,Thymocytes,LncRNA,MicroRNA,ACUTE LYMPHOBLASTIC-LEUKEMIA,COMPETING ENDOGENOUS RNA,TUMOR-SUPPRESSOR,CELL DEVELOPMENT,GENE-EXPRESSION,MICRORNA BIOGENESIS,GLUCOCORTICOID-RECEPTOR,MICROPROCESSOR COMPLEX,SIGNATURES DEFINE,MIRNA EXPRESSION},
  language     = {eng},
  pages        = {17},
  title        = {T-ALL and thymocytes : a message of noncoding RNAs},
  url          = {http://dx.doi.org/10.1186/s13045-017-0432-0},
  volume       = {10},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: