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Innovative approaches to treat Staphylococcus aureus biofilm-related infections

(2017) Essays in Biochemistry. 61(1). p.61-70
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Abstract
Many bacterial infections in humans and animals are caused by bacteria residing in biofilms, complex communities of attached organisms embedded in an extracellular matrix. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. This decreased susceptibility, together with conventional mechanisms leading to antimicrobial resistance, makes biofilm-related infections increasingly difficult to treat and alternative antibiofilm strategies are urgently required. In this review, we present three such strategies to combat biofilm-related infections with the important human pathogen Staphylococcus aureus: (i) targeting the bacterial communication system with quorum sensing (QS) inhibitors, (ii) a 'Trojan Horse' strategy to disturb iron metabolism by using gallium-based therapeutics and (iii) the use of 'non-antibiotics' with antibiofilm activity identified through screening of repurposing libraries.
Keywords
QUORUM-SENSING INHIBITORS, SEROTONIN REUPTAKE INHIBITORS, TRANSITION-METAL GALLIUM, PSEUDOMONAS-AERUGINOSA, IN-VITRO, ANTIMICROBIAL ACTIVITY, BACTERIAL BIOFILMS, ANTIBACTERIAL COMPOUNDS, HAMAMELITANNIN ANALOGS, ANTIBIOTIC-RESISTANCE

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Citation

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Chicago
Richter, Katharina, Freija Van den Driessche, and Tom Coenye. 2017. “Innovative Approaches to Treat Staphylococcus Aureus Biofilm-related Infections.” Ed. H Venter. Essays in Biochemistry 61 (1): 61–70.
APA
Richter, K., Van den Driessche, F., & Coenye, T. (2017). Innovative approaches to treat Staphylococcus aureus biofilm-related infections. (H. Venter, Ed.)Essays in Biochemistry, 61(1), 61–70.
Vancouver
1.
Richter K, Van den Driessche F, Coenye T. Innovative approaches to treat Staphylococcus aureus biofilm-related infections. Venter H, editor. Essays in Biochemistry. London, UK: Portland Press; 2017;61(1):61–70.
MLA
Richter, Katharina, Freija Van den Driessche, and Tom Coenye. “Innovative Approaches to Treat Staphylococcus Aureus Biofilm-related Infections.” Ed. H Venter. Essays in Biochemistry 61.1 (2017): 61–70. Print.
@article{8520630,
  abstract     = {Many bacterial infections in humans and animals are caused by bacteria residing in biofilms, complex communities of attached organisms embedded in an extracellular matrix. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. This decreased susceptibility, together with conventional mechanisms leading to antimicrobial resistance, makes biofilm-related infections increasingly difficult to treat and alternative antibiofilm strategies are urgently required. In this review, we present three such strategies to combat biofilm-related infections with the important human pathogen Staphylococcus aureus: (i) targeting the bacterial communication system with quorum sensing (QS) inhibitors, (ii) a 'Trojan Horse' strategy to disturb iron metabolism by using gallium-based therapeutics and (iii) the use of 'non-antibiotics' with antibiofilm activity identified through screening of repurposing libraries.},
  author       = {Richter, Katharina and Van den Driessche, Freija and Coenye, Tom},
  editor       = {Venter, H},
  isbn         = {9781855782051},
  issn         = {0071-1365},
  journal      = {Essays in Biochemistry},
  keyword      = {QUORUM-SENSING INHIBITORS,SEROTONIN REUPTAKE INHIBITORS,TRANSITION-METAL GALLIUM,PSEUDOMONAS-AERUGINOSA,IN-VITRO,ANTIMICROBIAL ACTIVITY,BACTERIAL BIOFILMS,ANTIBACTERIAL COMPOUNDS,HAMAMELITANNIN ANALOGS,ANTIBIOTIC-RESISTANCE},
  language     = {eng},
  number       = {1},
  pages        = {61--70},
  publisher    = {Portland Press},
  title        = {Innovative approaches to treat Staphylococcus aureus biofilm-related infections},
  url          = {http://dx.doi.org/10.1042/EBC20160056},
  volume       = {61},
  year         = {2017},
}

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