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Novel potentiators for vancomycin in the treatment of biofilm-related MRSA infections via a mix and match approach

Arno Vermote (UGent) , Gilles Brackman (UGent) , Martijn Risseeuw (UGent) , Davie Cappoen (UGent) , Paul Cos, Tom Coenye (UGent) and Serge Van Calenbergh (UGent)
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Abstract
A library of 52 hamamelitannin analogues was synthesized and investigated for its ability to potentiate the effect of vancomycin toward Staphylococcus aureus biofilms. Several compounds were found to effectively increase the susceptibility of staphylococcal biofilms toward this glycopeptide. The most active analogue identified in this study showed an EC50 value of 0.26 mu M.
Keywords
STAPHYLOCOCCUS-AUREUS INFECTIONS, QUORUM-SENSING INHIBITOR, HAMAMELITANNIN ANALOGS, BACTERIAL BIOFILMS, ANTIBIOTICS, SUSCEPTIBILITY, RESISTANCE, Antibiotic potentiators, Staphylococcus aureus, hamamelitannin, analogues, quorum sensing, biofilms

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MLA
Vermote, Arno et al. “Novel Potentiators for Vancomycin in the Treatment of Biofilm-related MRSA Infections via a Mix and Match Approach.” ACS MEDICINAL CHEMISTRY LETTERS 8.1 (2017): 38–42. Print.
APA
Vermote, A., Brackman, G., Risseeuw, M., Cappoen, D., Cos, P., Coenye, T., & Van Calenbergh, S. (2017). Novel potentiators for vancomycin in the treatment of biofilm-related MRSA infections via a mix and match approach. ACS MEDICINAL CHEMISTRY LETTERS, 8(1), 38–42.
Chicago author-date
Vermote, Arno, Gilles Brackman, Martijn Risseeuw, Davie Cappoen, Paul Cos, Tom Coenye, and Serge Van Calenbergh. 2017. “Novel Potentiators for Vancomycin in the Treatment of Biofilm-related MRSA Infections via a Mix and Match Approach.” Acs Medicinal Chemistry Letters 8 (1): 38–42.
Chicago author-date (all authors)
Vermote, Arno, Gilles Brackman, Martijn Risseeuw, Davie Cappoen, Paul Cos, Tom Coenye, and Serge Van Calenbergh. 2017. “Novel Potentiators for Vancomycin in the Treatment of Biofilm-related MRSA Infections via a Mix and Match Approach.” Acs Medicinal Chemistry Letters 8 (1): 38–42.
Vancouver
1.
Vermote A, Brackman G, Risseeuw M, Cappoen D, Cos P, Coenye T, et al. Novel potentiators for vancomycin in the treatment of biofilm-related MRSA infections via a mix and match approach. ACS MEDICINAL CHEMISTRY LETTERS. 2017;8(1):38–42.
IEEE
[1]
A. Vermote et al., “Novel potentiators for vancomycin in the treatment of biofilm-related MRSA infections via a mix and match approach,” ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 1, pp. 38–42, 2017.
@article{8520628,
  abstract     = {A library of 52 hamamelitannin analogues was synthesized and investigated for its ability to potentiate the effect of vancomycin toward Staphylococcus aureus biofilms. Several compounds were found to effectively increase the susceptibility of staphylococcal biofilms toward this glycopeptide. The most active analogue identified in this study showed an EC50 value of 0.26 mu M.},
  author       = {Vermote, Arno and Brackman, Gilles and Risseeuw, Martijn and Cappoen, Davie and Cos, Paul and Coenye, Tom and Van Calenbergh, Serge},
  issn         = {1948-5875},
  journal      = {ACS MEDICINAL CHEMISTRY LETTERS},
  keywords     = {STAPHYLOCOCCUS-AUREUS INFECTIONS,QUORUM-SENSING INHIBITOR,HAMAMELITANNIN ANALOGS,BACTERIAL BIOFILMS,ANTIBIOTICS,SUSCEPTIBILITY,RESISTANCE,Antibiotic potentiators,Staphylococcus aureus,hamamelitannin,analogues,quorum sensing,biofilms},
  language     = {eng},
  number       = {1},
  pages        = {38--42},
  title        = {Novel potentiators for vancomycin in the treatment of biofilm-related MRSA infections via a mix and match approach},
  url          = {http://dx.doi.org/10.1021/acsmedchemlett.6b00315},
  volume       = {8},
  year         = {2017},
}

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