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Effect of myocyte-fibroblast coupling on the onset of pathological dynamics in a model of ventricular tissue

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Abstract
Managing lethal cardiac arrhythmias is one of the biggest challenges in modern cardiology, and hence it is very important to understand the factors underlying such arrhythmias. While early afterdepolarizations (EAD) of cardiac cells is known to be one such arrhythmogenic factor, the mechanisms underlying the emergence of tissue level arrhythmias from cellular level EADs is not fully understood. Another known arrhythmogenic condition is fibrosis of cardiac tissue that occurs both due to aging and in many types of heart diseases. In this paper we describe the results of a systematic insilico study, using the TNNP model of human cardiac cells and MacCannell model for (myo) fibroblasts, on the possible effects of diffuse fibrosis on arrhythmias occurring via EADs. We find that depending on the resting potential of fibroblasts (VFR), M-F coupling can either increase or decrease the region of parameters showing EADs. Fibrosis increases the probability of occurrence of arrhythmias after a single focal stimulation and this effect increases with the strength of the M-F coupling. While in our simulations, arrhythmias occur due to fibrosis induced ectopic activity, we do not observe any specific fibrotic pattern that promotes the occurrence of these ectopic sources.
Keywords
EARLY AFTERDEPOLARIZATIONS, CARDIAC FIBROBLASTS, GLYCOLYTIC INHIBITION, ATRIAL-FIBRILLATION, AGED HEARTS, ARRHYTHMIAS, FIBROSIS, MYOFIBROBLASTS, REPOLARIZATION, REENTRANT

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MLA
Sridhar, S, Nele Vandersickel, and Alexander Panfilov. “Effect of Myocyte-fibroblast Coupling on the Onset of Pathological Dynamics in a Model of Ventricular Tissue.” SCIENTIFIC REPORTS 7 (2017): n. pag. Print.
APA
Sridhar, S., Vandersickel, N., & Panfilov, A. (2017). Effect of myocyte-fibroblast coupling on the onset of pathological dynamics in a model of ventricular tissue. SCIENTIFIC REPORTS, 7.
Chicago author-date
Sridhar, S, Nele Vandersickel, and Alexander Panfilov. 2017. “Effect of Myocyte-fibroblast Coupling on the Onset of Pathological Dynamics in a Model of Ventricular Tissue.” Scientific Reports 7.
Chicago author-date (all authors)
Sridhar, S, Nele Vandersickel, and Alexander Panfilov. 2017. “Effect of Myocyte-fibroblast Coupling on the Onset of Pathological Dynamics in a Model of Ventricular Tissue.” Scientific Reports 7.
Vancouver
1.
Sridhar S, Vandersickel N, Panfilov A. Effect of myocyte-fibroblast coupling on the onset of pathological dynamics in a model of ventricular tissue. SCIENTIFIC REPORTS. 2017;7.
IEEE
[1]
S. Sridhar, N. Vandersickel, and A. Panfilov, “Effect of myocyte-fibroblast coupling on the onset of pathological dynamics in a model of ventricular tissue,” SCIENTIFIC REPORTS, vol. 7, 2017.
@article{8520522,
  abstract     = {Managing lethal cardiac arrhythmias is one of the biggest challenges in modern cardiology, and hence it is very important to understand the factors underlying such arrhythmias. While early afterdepolarizations (EAD) of cardiac cells is known to be one such arrhythmogenic factor, the mechanisms underlying the emergence of tissue level arrhythmias from cellular level EADs is not fully understood. Another known arrhythmogenic condition is fibrosis of cardiac tissue that occurs both due to aging and in many types of heart diseases. In this paper we describe the results of a systematic insilico study, using the TNNP model of human cardiac cells and MacCannell model for (myo) fibroblasts, on the possible effects of diffuse fibrosis on arrhythmias occurring via EADs. We find that depending on the resting potential of fibroblasts (VFR), M-F coupling can either increase or decrease the region of parameters showing EADs. Fibrosis increases the probability of occurrence of arrhythmias after a single focal stimulation and this effect increases with the strength of the M-F coupling. While in our simulations, arrhythmias occur due to fibrosis induced ectopic activity, we do not observe any specific fibrotic pattern that promotes the occurrence of these ectopic sources.},
  articleno    = {40985},
  author       = {Sridhar, S and Vandersickel, Nele and Panfilov, Alexander},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keywords     = {EARLY AFTERDEPOLARIZATIONS,CARDIAC FIBROBLASTS,GLYCOLYTIC INHIBITION,ATRIAL-FIBRILLATION,AGED HEARTS,ARRHYTHMIAS,FIBROSIS,MYOFIBROBLASTS,REPOLARIZATION,REENTRANT},
  language     = {eng},
  pages        = {12},
  title        = {Effect of myocyte-fibroblast coupling on the onset of pathological dynamics in a model of ventricular tissue},
  url          = {http://dx.doi.org/10.1038/srep40985},
  volume       = {7},
  year         = {2017},
}

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