Advanced search
1 file | 221.30 KB

Former smoking and early and long-term graft outcome in renal transplant recipients : a retrospective cohort study

Steven Van Laecke (UGent) , Evi Nagler (UGent) , Patrick Peeters (UGent) , Francis Verbeke (UGent) and Wim Van Biesen (UGent)
(2017) TRANSPLANT INTERNATIONAL. 30(2). p.187-195
Author
Organization
Abstract
Smoking is associated with unfavourable outcome in solid-organ transplant recipients. Nicotine may predispose to kidney injury by increasing oxidative stress. We hypothesized that former smoking negatively affects graft outcome in kidney transplant recipients and especially those with delayed graft function (DGF). We included adult recipients of a kidney transplant between 1 January 2003 and 1 October 2015 at Ghent University Hospital and recorded outcomes until 31 October 2015. We used Kaplan-Meier and multivariable Cox proportional hazard analysis to examine the relationship between former smoking at the time of transplantation and the incidence of 10-year graft loss with and without censoring for death in 1013 participants. We evaluated mean differences in eGFR over time by a random intercept and slope model, considering a linear time effect. After adjusting for potential confounders, a history of smoking was associated with an increased hazard of graft loss (adjusted hazard ratio (aHR) 1.60; 95% CI: 1.17-2.17; P = 0.003) and death-censored graft loss (aHR 2.29; 95% CI: 1.41-3.72; P = 0.001). The linear time trend of eGFR was different between former and never smokers (P = 0.001). To conclude, former smoking exerts long-lasting negative effects on graft outcome and this independent of DGF.
Keywords
CHRONIC KIDNEY-DISEASE, CIGARETTE-SMOKING, LUNG TRANSPLANTATION, NICOTINE EXPOSURE, TOBACCO USE, INJURY, PROGRESSION, MANAGEMENT, SMOKERS, delayed graft function, graft survival, nicotine, previous smoking, rejection

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 221.30 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Van Laecke, Steven, Evi Nagler, PATRICK PEETERS, Francis Verbeke, and Wim Van Biesen. 2017. “Former Smoking and Early and Long-term Graft Outcome in Renal Transplant Recipients : a Retrospective Cohort Study.” Transplant International 30 (2): 187–195.
APA
Van Laecke, S., Nagler, E., PEETERS, P., Verbeke, F., & Van Biesen, W. (2017). Former smoking and early and long-term graft outcome in renal transplant recipients : a retrospective cohort study. TRANSPLANT INTERNATIONAL, 30(2), 187–195.
Vancouver
1.
Van Laecke S, Nagler E, PEETERS P, Verbeke F, Van Biesen W. Former smoking and early and long-term graft outcome in renal transplant recipients : a retrospective cohort study. TRANSPLANT INTERNATIONAL. 2017;30(2):187–95.
MLA
Van Laecke, Steven, Evi Nagler, PATRICK PEETERS, et al. “Former Smoking and Early and Long-term Graft Outcome in Renal Transplant Recipients : a Retrospective Cohort Study.” TRANSPLANT INTERNATIONAL 30.2 (2017): 187–195. Print.
@article{8519611,
  abstract     = {Smoking is associated with unfavourable outcome in solid-organ transplant recipients. Nicotine may predispose to kidney injury by increasing oxidative stress. We hypothesized that former smoking negatively affects graft outcome in kidney transplant recipients and especially those with delayed graft function (DGF). We included adult recipients of a kidney transplant between 1 January 2003 and 1 October 2015 at Ghent University Hospital and recorded outcomes until 31 October 2015. We used Kaplan-Meier and multivariable Cox proportional hazard analysis to examine the relationship between former smoking at the time of transplantation and the incidence of 10-year graft loss with and without censoring for death in 1013 participants. We evaluated mean differences in eGFR over time by a random intercept and slope model, considering a linear time effect. After adjusting for potential confounders, a history of smoking was associated with an increased hazard of graft loss (adjusted hazard ratio (aHR) 1.60; 95\% CI: 1.17-2.17; P = 0.003) and death-censored graft loss (aHR 2.29; 95\% CI: 1.41-3.72; P = 0.001). The linear time trend of eGFR was different between former and never smokers (P = 0.001). To conclude, former smoking exerts long-lasting negative effects on graft outcome and this independent of DGF.},
  author       = {Van Laecke, Steven and Nagler, Evi and Peeters, Patrick and Verbeke, Francis and Van Biesen, Wim},
  issn         = {0934-0874},
  journal      = {TRANSPLANT INTERNATIONAL},
  keyword      = {CHRONIC KIDNEY-DISEASE,CIGARETTE-SMOKING,LUNG TRANSPLANTATION,NICOTINE EXPOSURE,TOBACCO USE,INJURY,PROGRESSION,MANAGEMENT,SMOKERS,delayed graft function,graft survival,nicotine,previous smoking,rejection},
  language     = {eng},
  number       = {2},
  pages        = {187--195},
  title        = {Former smoking and early and long-term graft outcome in renal transplant recipients : a retrospective cohort study},
  url          = {http://dx.doi.org/10.1111/tri.12897},
  volume       = {30},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: