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Fuchs’ Uveitis syndrome : no longer a syndrome?

Elke Kreps (UGent) , Thierry Derveaux (UGent) , Filip De Keyser (UGent) and Philippe Kestelyn (UGent)
Author
Organization
Abstract
Purpose: Rubella virus (RV) has a central role in the etiopathogenesis of Fuchs' uveitis syndrome (FUS). We aim to offer new insights by comprehensive analysis of recent laboratory and epidemiologic data. Methods: We conducted a literature search for laboratory data and papers on etiopathogenesis. Results: Aqueous humour samples of FUS patients show immunoreactivity to RV, in a specific and sensitive manner. Identification of RV genome confirm intraocular infection in a subset of FUS patients. Epidemiologic findings further support causality. The clinical spectrum of RV-associated uveitis is similar but not identical to FUS. FUS eyes exhibit a predominance of CD8 + T cells, high IFN-? and IL-10 levels. Conclusions: RV is the leading cause of FUS. Cytokine-based findings mirror a viral etiology and chronic low-grade inflammation. RV-associated FUS represents a common pathway of intraocular RV inoculation after congenital or acquired infection. Other causes, including HSV and CMV, may lead to FUS.
Keywords
Cytokines, etiology, Fuchs' uveitis syndrome, immunology, rubella virus, INTRAOCULAR ANTIBODY-SYNTHESIS, CONGENITAL-RUBELLA SYNDROME, VIRUS-ASSOCIATED UVEITIS, AQUEOUS-HUMOR, HETEROCHROMIC CYCLITIS, T-CELLS, CYTOKINE PROFILES, ANTERIOR UVEITIS, UNITED-STATES, CLINICAL-MANIFESTATIONS

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Citation

Please use this url to cite or link to this publication:

Chicago
Kreps, Elke, Thierry Derveaux, Filip De Keyser, and Philippe Kestelyn. 2016. “Fuchs’ Uveitis Syndrome : No Longer a Syndrome?” Ocular Immunology and Inflammation 24 (3): 348–357.
APA
Kreps, E., Derveaux, T., De Keyser, F., & Kestelyn, P. (2016). Fuchs’ Uveitis syndrome : no longer a syndrome? OCULAR IMMUNOLOGY AND INFLAMMATION, 24(3), 348–357.
Vancouver
1.
Kreps E, Derveaux T, De Keyser F, Kestelyn P. Fuchs’ Uveitis syndrome : no longer a syndrome? OCULAR IMMUNOLOGY AND INFLAMMATION. 2016;24(3):348–57.
MLA
Kreps, Elke et al. “Fuchs’ Uveitis Syndrome : No Longer a Syndrome?” OCULAR IMMUNOLOGY AND INFLAMMATION 24.3 (2016): 348–357. Print.
@article{8519474,
  abstract     = {Purpose: Rubella virus (RV) has a central role in the etiopathogenesis of Fuchs' uveitis syndrome (FUS). We aim to offer new insights by comprehensive analysis of recent laboratory and epidemiologic data. 
Methods: We conducted a literature search for laboratory data and papers on etiopathogenesis. 
Results: Aqueous humour samples of FUS patients show immunoreactivity to RV, in a specific and sensitive manner. Identification of RV genome confirm intraocular infection in a subset of FUS patients. Epidemiologic findings further support causality. The clinical spectrum of RV-associated uveitis is similar but not identical to FUS. FUS eyes exhibit a predominance of CD8 + T cells, high IFN-? and IL-10 levels. 
Conclusions: RV is the leading cause of FUS. Cytokine-based findings mirror a viral etiology and chronic low-grade inflammation. RV-associated FUS represents a common pathway of intraocular RV inoculation after congenital or acquired infection. Other causes, including HSV and CMV, may lead to FUS.},
  author       = {Kreps, Elke and Derveaux, Thierry and De Keyser, Filip and Kestelyn, Philippe},
  issn         = {0927-3948},
  journal      = {OCULAR IMMUNOLOGY AND INFLAMMATION},
  keywords     = {Cytokines,etiology,Fuchs' uveitis syndrome,immunology,rubella virus,INTRAOCULAR ANTIBODY-SYNTHESIS,CONGENITAL-RUBELLA SYNDROME,VIRUS-ASSOCIATED UVEITIS,AQUEOUS-HUMOR,HETEROCHROMIC CYCLITIS,T-CELLS,CYTOKINE PROFILES,ANTERIOR UVEITIS,UNITED-STATES,CLINICAL-MANIFESTATIONS},
  language     = {eng},
  number       = {3},
  pages        = {348--357},
  title        = {Fuchs’ Uveitis syndrome : no longer a syndrome?},
  url          = {http://dx.doi.org/10.3109/09273948.2015.1005239},
  volume       = {24},
  year         = {2016},
}

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