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Associative reinstatement memory measures hippocampal function in Parkinson's Disease

(2016) NEUROPSYCHOLOGIA. 90. p.25-32
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Abstract
In Parkinson's Disease (PD), hippocampal atrophy is associated with rapid cognitive decline. Hippocampal function is typically assessed using memory tests but current clinical tools (e.g., free recall) also rely on executive functions or use material that is not optimally engaging hippocampal memory networks. Because of the ubiquity of executive dysfunction in PD, our ability to detect true memory deficits is suboptimal. Our previous behavioural and neuroimaging work in other populations suggests that an experimental memory task Associative Reinstatement Memory (ARM) may prove useful in investigating hippocampal function in PD. In this study, we investigated whether ARM is compromised in PD and we assessed its convergent and divergent validity by comparing it to standardized measures of memory and of attention and executive functioning in PD, respectively. Using fMRI, we also investigated whether performance in PD relates to degree of hippocampal engagement. Fifteen participants with PD and 13 age-matched healthy controls completed neuropsychological testing as well as an ARM fMRI recognition paradigm in which they were instructed to identify word pairs comprised of two studied words (intact or rearranged pairs) and those containing at least one new word (new or half new pairs). ARM is measured by the differences in hit rates between intact and rearranged pairs. Behaviourally, ARM was poorer in PD relative to controls and was correlated with verbal memory measures, but not with attention or executive functioning in the PD group. Hippocampal activation associated with ARM was reduced in PD relative to controls and covaried with ARM scores in both groups. To conclude, ARM is a sensitive measure of hippocampal memory function that is unaffected by attention or executive dysfunction in PD. Our study highlights the benefit of integrating cognitive neuroscience frameworks and novel experimental tasks to improve the practice of clinical neuropsychology in PD. (C) 2016 Elsevier Ltd. All rights reserved.
Keywords
MILD COGNITIVE IMPAIRMENT, RETRIEVAL DEFICIT HYPOTHESIS, RECOGNITION, MEMORY, DIAGNOSTIC-CRITERIA, EXECUTIVE FUNCTION, VERBAL MEMORY, RECOLLECTION, FAMILIARITY, DEMENTIA, ATROPHY, Associative memory, Recognition, Hippocampus, FMRI, Parkinson's Disease

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Citation

Please use this url to cite or link to this publication:

Chicago
Cohn, Melanie, Irene Giannoylis, Maya De Belder, Jean A Saint-Cyr, and Mary Pat McAndrews. 2016. “Associative Reinstatement Memory Measures Hippocampal Function in Parkinson’s Disease.” Neuropsychologia 90: 25–32.
APA
Cohn, M., Giannoylis, I., De Belder, M., Saint-Cyr, J. A., & McAndrews, M. P. (2016). Associative reinstatement memory measures hippocampal function in Parkinson’s Disease. NEUROPSYCHOLOGIA, 90, 25–32.
Vancouver
1.
Cohn M, Giannoylis I, De Belder M, Saint-Cyr JA, McAndrews MP. Associative reinstatement memory measures hippocampal function in Parkinson’s Disease. NEUROPSYCHOLOGIA. Oxford: Pergamon-elsevier Science Ltd; 2016;90:25–32.
MLA
Cohn, Melanie, Irene Giannoylis, Maya De Belder, et al. “Associative Reinstatement Memory Measures Hippocampal Function in Parkinson’s Disease.” NEUROPSYCHOLOGIA 90 (2016): 25–32. Print.
@article{8519253,
  abstract     = {In Parkinson's Disease (PD), hippocampal atrophy is associated with rapid cognitive decline. Hippocampal function is typically assessed using memory tests but current clinical tools (e.g., free recall) also rely on executive functions or use material that is not optimally engaging hippocampal memory networks. Because of the ubiquity of executive dysfunction in PD, our ability to detect true memory deficits is suboptimal. Our previous behavioural and neuroimaging work in other populations suggests that an experimental memory task Associative Reinstatement Memory (ARM) may prove useful in investigating hippocampal function in PD. In this study, we investigated whether ARM is compromised in PD and we assessed its convergent and divergent validity by comparing it to standardized measures of memory and of attention and executive functioning in PD, respectively. Using fMRI, we also investigated whether performance in PD relates to degree of hippocampal engagement. Fifteen participants with PD and 13 age-matched healthy controls completed neuropsychological testing as well as an ARM fMRI recognition paradigm in which they were instructed to identify word pairs comprised of two studied words (intact or rearranged pairs) and those containing at least one new word (new or half new pairs). ARM is measured by the differences in hit rates between intact and rearranged pairs. Behaviourally, ARM was poorer in PD relative to controls and was correlated with verbal memory measures, but not with attention or executive functioning in the PD group. Hippocampal activation associated with ARM was reduced in PD relative to controls and covaried with ARM scores in both groups. To conclude, ARM is a sensitive measure of hippocampal memory function that is unaffected by attention or executive dysfunction in PD. Our study highlights the benefit of integrating cognitive neuroscience frameworks and novel experimental tasks to improve the practice of clinical neuropsychology in PD. (C) 2016 Elsevier Ltd. All rights reserved.},
  author       = {Cohn, Melanie and Giannoylis, Irene and De Belder, Maya and Saint-Cyr, Jean A and McAndrews, Mary Pat},
  issn         = {0028-3932},
  journal      = {NEUROPSYCHOLOGIA},
  keyword      = {MILD COGNITIVE IMPAIRMENT,RETRIEVAL DEFICIT HYPOTHESIS,RECOGNITION,MEMORY,DIAGNOSTIC-CRITERIA,EXECUTIVE FUNCTION,VERBAL MEMORY,RECOLLECTION,FAMILIARITY,DEMENTIA,ATROPHY,Associative memory,Recognition,Hippocampus,FMRI,Parkinson's Disease},
  language     = {eng},
  pages        = {25--32},
  publisher    = {Pergamon-elsevier Science Ltd},
  title        = {Associative reinstatement memory measures hippocampal function in Parkinson's Disease},
  url          = {http://dx.doi.org/10.1016/j.neuropsychologia.2016.04.026},
  volume       = {90},
  year         = {2016},
}

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