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In vivo imaging of the stability and sustained cargo release of an injectable amphipathic peptide-based hydrogel

Edith Oyen, Charlotte Martin, Vicky Caveliers, Annemieke Madder UGent, Bruno Van Mele, Richard Hoogenboom UGent, Sophie Hemot and Steven Ballet (2017) BIOMACROMOLECULES. 18(3). p.994-1001
abstract
Hydrogels are promising materials for biomedical applications such as tissue engineering and controlled drug release. In the past two decades, the peptide hydrogel subclass has attracted an increasing level of interest from the scientific community because of its numerous advantages, such as biocompatibility, biodegradability, and, most importantly, injectability. Here, we report on a hydrogel consisting of the amphipathic hexapeptide H-FEFQFK-NH2, which has previously shown promising in vivo properties in terms of releasing morphine. In this study, the release of a small molecule, a peptide, and a protein cargo as representatives of the three major drug classes is directly visualized by in vivo fluorescence and nuclear imaging. In addition, the in vivo stability of the peptide hydrogel system is investigated through the use of a radiolabeled hydrogelator sequence. Although it is shown that the hydrogel remains present for several days, the largest decrease in volume takes place within the first 12 h of subcutaneous injection, which is also the time frame wherein the cargos are released. Compared to the situation in which the cargos are injected in solution, a prolonged release profile is observed up to 12 h, showing the potential of our hydrogel system as a scaffold for controlled drug delivery. Importantly, this study elucidates the release mechanism of the peptide hydrogel system that seems to be based on erosion of the hydrogel providing a generally applicable controlled release platform for small molecule, peptide, and protein drugs.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DRUG-DELIVERY, NANOFIBERS, CHALLENGES, SYSTEMS, OPIOIDS, DESIGN, FUTURE
journal title
BIOMACROMOLECULES
Biomacromolecules
volume
18
issue
3
pages
994 - 1001
Web of Science type
Article
Web of Science id
000396379600034
ISSN
1525-7797
1526-4602
DOI
10.1021/acsbiomac.6b01840
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8518892
handle
http://hdl.handle.net/1854/LU-8518892
date created
2017-04-28 07:25:00
date last changed
2017-05-23 09:49:24
@article{8518892,
  abstract     = {Hydrogels are promising materials for biomedical applications such as tissue engineering and controlled drug release. In the past two decades, the peptide hydrogel subclass has attracted an increasing level of interest from the scientific community because of its numerous advantages, such as biocompatibility, biodegradability, and, most importantly, injectability. Here, we report on a hydrogel consisting of the amphipathic hexapeptide H-FEFQFK-NH2, which has previously shown promising in vivo properties in terms of releasing morphine. In this study, the release of a small molecule, a peptide, and a protein cargo as representatives of the three major drug classes is directly visualized by in vivo fluorescence and nuclear imaging. In addition, the in vivo stability of the peptide hydrogel system is investigated through the use of a radiolabeled hydrogelator sequence. Although it is shown that the hydrogel remains present for several days, the largest decrease in volume takes place within the first 12 h of subcutaneous injection, which is also the time frame wherein the cargos are released. Compared to the situation in which the cargos are injected in solution, a prolonged release profile is observed up to 12 h, showing the potential of our hydrogel system as a scaffold for controlled drug delivery. Importantly, this study elucidates the release mechanism of the peptide hydrogel system that seems to be based on erosion of the hydrogel providing a generally applicable controlled release platform for small molecule, peptide, and protein drugs.},
  author       = {Oyen, Edith and Martin, Charlotte and Caveliers, Vicky and Madder, Annemieke and Van Mele, Bruno and Hoogenboom, Richard and Hemot, Sophie and Ballet, Steven},
  issn         = {1525-7797},
  journal      = {BIOMACROMOLECULES},
  keyword      = {DRUG-DELIVERY,NANOFIBERS,CHALLENGES,SYSTEMS,OPIOIDS,DESIGN,FUTURE},
  language     = {eng},
  number       = {3},
  pages        = {994--1001},
  title        = {In vivo imaging of the stability and sustained cargo release of an injectable amphipathic peptide-based hydrogel},
  url          = {http://dx.doi.org/10.1021/acsbiomac.6b01840},
  volume       = {18},
  year         = {2017},
}

Chicago
Oyen, Edith, Charlotte Martin, Vicky Caveliers, Annemieke Madder, Bruno Van Mele, Richard Hoogenboom, Sophie Hemot, and Steven Ballet. 2017. “In Vivo Imaging of the Stability and Sustained Cargo Release of an Injectable Amphipathic Peptide-based Hydrogel.” Biomacromolecules 18 (3): 994–1001.
APA
Oyen, E., Martin, C., Caveliers, V., Madder, A., Van Mele, B., Hoogenboom, R., Hemot, S., et al. (2017). In vivo imaging of the stability and sustained cargo release of an injectable amphipathic peptide-based hydrogel. BIOMACROMOLECULES, 18(3), 994–1001.
Vancouver
1.
Oyen E, Martin C, Caveliers V, Madder A, Van Mele B, Hoogenboom R, et al. In vivo imaging of the stability and sustained cargo release of an injectable amphipathic peptide-based hydrogel. BIOMACROMOLECULES. 2017;18(3):994–1001.
MLA
Oyen, Edith, Charlotte Martin, Vicky Caveliers, et al. “In Vivo Imaging of the Stability and Sustained Cargo Release of an Injectable Amphipathic Peptide-based Hydrogel.” BIOMACROMOLECULES 18.3 (2017): 994–1001. Print.